Life-cycle-coupled evolution of mitosis in close relatives of animals

• 成果类型: Article
• 署名作者: Shah, Hiral; Olivetta, Marine; Bhickta, Chandni; Ronchi, Paolo; Trupinic, Monika; Tromer, Eelco C.; Tolic, Iva M.; Schwab, Yannick; Dudin, Omaya; Dey, Gautam
• 署名单位: European Molecular Biology Laboratory (EMBL); Swiss Institute Experimental Cancer Research; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); European Molecular Biology Laboratory (EMBL); University of Groningen
• 刊物名称: Nature
• ISSN/ISSBN: 0028-4512
• DOI: 10.1038/s41586-024-07430-z
• 发表日期: 2024-06-06
• 关键词: nuclear-envelope; cell-division; DYNAMICS; origin

摘要

Eukaryotes have evolved towards one of two extremes along a spectrum of strategies for remodelling the nuclear envelope during cell division: disassembling the nuclear envelope in an open mitosis or constructing an intranuclear spindle in a closed mitosis 1,2 . Both classes of mitotic remodelling involve key differences in the core division machinery but the evolutionary reasons for adopting a specific mechanism are unclear. Here we use an integrated comparative genomics and ultrastructural imaging approach to investigate mitotic strategies in Ichthyosporea, close relatives of animals and fungi. We show that species in this clade have diverged towards either a fungal-like closed mitosis or an animal-like open mitosis, probably to support distinct multinucleated or uninucleated states. Our results indicate that multinucleated life cycles favour the evolution of closed mitosis. We analyse cell division in ichthyosporeans and find that multinucleated life cycles favour the evolution of closed mitosis, in which the cell constructs a spindle within an intact nucleus.