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作者：Zernicka-Goetz, Magdalena; Hyun, Insoo
作者单位：California Institute of Technology
摘要：Letter to the Editor
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作者：Wu, Jingjing; Deng, Jue; Theocharidis, Georgios; Sarrafian, Tiffany L.; Griffiths, Leigh G.; Bronson, Roderick T.; Veves, Aristidis; Chen, Jianzhu; Yuk, Hyunwoo; Zhao, Xuanhe
作者单位：Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Joslin Diabetes Center, Inc.; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Mayo Clinic; Mayo Clinic; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要：Implanted biomaterials and devices face compromised functionality and efficacy in the long term owing to foreign body reactions and subsequent formation of fibrous capsules at the implant-tissue interfaces 1-4 . Here we demonstrate that an adhesive implant-tissue interface can mitigate fibrous capsule formation in diverse animal models, including rats, mice, humanized mice and pigs, by reducing the level of infiltration of inflammatory cells into the adhesive implant-tissue interface compared ...
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作者：Dolgin, Elie
摘要：The same mRNA technology that quickly brought the world a vaccine for COVID-19 is now showing promise as a bespoke therapy for cancer.
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作者：Mallapaty, Smriti
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作者：Lane, Julia; Owen-Smith, Jason; Weinberg, Bruce A.
作者单位：New York University; University of Michigan System; University of Michigan; University System of Ohio; Ohio State University
摘要：National statistics systems should recognize the researchers whose ideas drive artificial-intelligence applications, not just machines and factory outputs.
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作者：Marchesan, Silvia
作者单位：University of Trieste
摘要：A simple peptide has been found to make disordered interactions with water, forming a self-healing glass that can also be used as an adhesive coating. The findings point the way to sustainable alternatives to conventional glass.
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作者：Guan, Xiangnan; Hu, Ruozhen; Choi, Yoonha; Srivats, Shyam; Nabet, Barzin Y.; Silva, John; Mcginnis, Lisa; Hendricks, Robert; Nutsch, Katherine; Banta, Karl L.; Duong, Ellen; Dunkle, Alexis; Chang, Patrick S.; Han, Chia-Jung; Mittman, Stephanie; Molden, Nandini; Daggumati, Pallavi; Connolly, Wendy; Johnson, Melissa; Abreu, Delvys Rodriguez; Cho, Byoung Chul; Italiano, Antoine; Gil-Bazo, Ignacio; Felip, Enriqueta; Mellman, Ira; Mariathasan, Sanjeev; Shames, David S.; Meng, Raymond; Chiang, Eugene Y.; Johnston, Robert J.; Patil, Namrata S.
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作者：Chaudun, Fabrice; Python, Laurena; Liu, Yu; Hiver, Agnes; Cand, Jennifer; Kieffer, Brigitte L.; Valjent, Emmanuel; Luescher, Christian
作者单位：University of Geneva; Universite de Lorraine; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Institut National de la Sante et de la Recherche Medicale (Inserm); University of Geneva
摘要：Fentanyl is a powerful painkiller that elicits euphoria and positive reinforcement(1). Fentanyl also leads to dependence, defined by the aversive withdrawal syndrome, which fuels negative reinforcement(2,3) (that is, individuals retake the drug to avoid withdrawal). Positive and negative reinforcement maintain opioid consumption, which leads to addiction in one-fourth of users, the largest fraction for all addictive drugs(4). Among the opioid receptors, mu-opioid receptors have a key role(5), ...
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作者：Dowding, Ian; Schuh, Christopher A.
作者单位：Massachusetts Institute of Technology (MIT); Northwestern University
摘要：The strength of materials depends on the rate at which they are tested, as defects, for example dislocations, that move in response to applied strains have intrinsic kinetic limitations(1-4). As the deformation strain rate increases, more strengthening mechanisms become active and increase the strength(4-7). However, the regime in which this transition happens has been difficult to access with traditional micromechanical strength measurements. Here, with microballistic impact testing at strain...
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作者：Zhang, Heng; Yin, Yu-Ling; Dai, Antao; Zhang, Tianwei; Zhang, Chao; Wu, Canrong; Hu, Wen; He, Xinheng; Pan, Benxun; Jin, Sanshan; Yuan, Qingning; Wang, Ming-Wei; Yang, Dehua; Xu, H. Eric; Jiang, Yi
作者单位：Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Lingang Laboratory; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; ShanghaiTech University; Fudan University; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Fudan University; Hainan Medical University
摘要：The noradrenaline transporter has a pivotal role in regulating neurotransmitter balance and is crucial for normal physiology and neurobiology(1). Dysfunction of noradrenaline transporter has been implicated in numerous neuropsychiatric diseases, including depression and attention deficit hyperactivity disorder(2). Here we report cryo-electron microscopy structures of noradrenaline transporter in apo and substrate-bound forms, and as complexes with six antidepressants. The structures reveal a n...
