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作者：Zheng, Xiao-Feng; Sarkar, Aniruddha; Lotana, Humphrey; Syed, Aleem; Nguyen, Huy; Ivey, Richard G.; Kennedy, Jacob J.; Whiteaker, Jeffrey R.; Tomasik, Bartlomiej; Huang, Kaimeng; Li, Feng; DAndrea, Alan D.; Paulovich, Amanda G.; Shah, Kavita; Spektor, Alexander; Chowdhury, Dipanjan
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Purdue University System; Purdue University; Purdue University System; Purdue University; Fred Hutchinson Cancer Center; Medical University Lodz; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Fahrenheit Universities; Medical University Gdansk
摘要：CDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to drive mitotic progression1. Here we demonstrate that CDK5 is active during mitosis and is necessary for maintaining mitotic fidelity. CDK5 is an atypical CDK owing to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p392. Here, using independent chemical genetic approaches, we specifically abrogated CDK5 activity during mitosis, and observed mitotic defects, nuclear...
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作者：Kozlov, Max
摘要：A mechanism for metabolic disease is traced to a defective cellular scaffolding that holds together the brain's hunger cells. A mechanism for metabolic disease is traced to a defective cellular scaffolding that holds together the brain's hunger cells.
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作者：Zhao, Jie; Yue, Chao; Wang, Jiaming; Hantson, Stijn; Wang, Xianli; He, Binbin; Li, Guangyao; Wang, Liang; Zhao, Hongfei; Luyssaert, Sebastiaan
作者单位：Northwest A&F University - China; Linyi University; Northwest A&F University - China; Northwest A&F University - China; Northwest A&F University - China; Universidad del Rosario; Natural Resources Canada; Canadian Forest Service; University of Electronic Science & Technology of China; Vrije Universiteit Amsterdam
摘要：Climate warming has caused a widespread increase in extreme fire weather, making forest fires longer-lived and larger1-3. The average forest fire size in Canada, the USA and Australia has doubled or even tripled in recent decades4,5. In return, forest fires feed back to climate by modulating land-atmospheric carbon, nitrogen, aerosol, energy and water fluxes6-8. However, the surface climate impacts of increasingly large fires and their implications for land management remain to be established....
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作者：Imada, Shinya; Khawaled, Saleh; Shin, Heaji; Meckelmann, Sven W.; Whittaker, Charles A.; Correa, Renan Oliveira; Alquati, Chiara; Lu, Yixin; Tie, Guodong; Pradhan, Dikshant; Calibasi-Kocal, Gizem; Melo, Luiza Martins Nascentes; Allies, Gabriele; Roesler, Jonas; Wittenhofer, Pia; Krystkiewicz, Jonathan; Schmitz, Oliver J.; Roper, Jatin; Vinolo, Marco Aurelio Ramirez; Ricciardiello, Luigi; Lien, Evan C.; Vander Heiden, Matthew G.; Shivdasani, Ramesh A.; Cheng, Chia-Wei; Tasdogan, Alpaslan; Yilmaz, Oemer H.
作者单位：Massachusetts Institute of Technology (MIT); University of Duisburg Essen; Massachusetts Institute of Technology (MIT); Universidade de Sao Paulo; Universidade Estadual de Campinas; Universidade Estadual de Campinas; University of Bologna; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Dokuz Eylul University; University of Duisburg Essen; Helmholtz Association; German Cancer Research Center (DKFZ); Duke University; Duke University; University of Texas System; UTMD Anderson Cancer Center; Van Andel Institute; Columbia University; NewYork-Presbyterian Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Massachusetts General Hospital; Harvard University; Harvard Medical School
摘要：For over a century, fasting regimens have improved health, lifespan and tissue regeneration in diverse organisms, including humans1-6. However, how fasting and post-fast refeeding affect adult stem cells and tumour formation has yet to be explored in depth. Here we demonstrate that post-fast refeeding increases intestinal stem cell (ISC) proliferation and tumour formation; post-fast refeeding augments the regenerative capacity of Lgr5+ ISCs, and loss of the tumour suppressor gene Apc in post-f...
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作者：Tacon, Dave
摘要：Rebecca Hsu works as a forest ecologist for the Taiwan Forestry Institute in Taipei.
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作者：[Anonymous]
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作者：[Anonymous]
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作者：[Anonymous]
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作者：Ng, Christine S. C.; Liu, Aofei; Cui, Bianxiao; Banik, Steven M.
作者单位：Stanford University; Stanford University
摘要：Subcellular protein localization regulates protein function and can be corrupted in cancers(1) and neurodegenerative diseases(2,3). The rewiring of localization to address disease-driving phenotypes would be an attractive targeted therapeutic approach. Molecules that harness the trafficking of a shuttle protein to control the subcellular localization of a target protein could enforce targeted protein relocalization and rewire the interactome. Here we identify a collection of shuttle proteins w...
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作者：Dickopf, Stefan; Sikora, Bastian; Kaiser, Annabelle; Mueller, Marius; Ulmer, Stefan; Yerokhin, Vladimir A.; Harman, Zoltan; Keitel, Christoph H.; Mooser, Andreas; Blaum, Klaus
