Nature

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• Long-lasting heart-failure treatment could be a game-changer AI翻译
  作者：Burnett Jr, John C.
  作者单位：Mayo Clinic; Mayo Clinic
• Observation-constrained projections reveal longer-than-expected dry spells AI翻译
  作者：Petrova, Irina Y.; Miralles, Diego G.; Brient, Florent; Donat, Markus G.; Min, Seung-Ki; Kim, Yeon-Hee; Bador, Margot
  作者单位：Ghent University; Institut Polytechnique de Paris; Ecole des Ponts ParisTech; Ecole Polytechnique; Universite Paris Cite; Sorbonne Universite; Universitat Politecnica de Catalunya; Barcelona Supercomputer Center (BSC-CNS); ICREA; Pohang University of Science & Technology (POSTECH); Yonsei University; CERFACS; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse
  摘要：Climate models indicate that dry extremes will be exacerbated in many regions of the world1,2. However, confidence in the magnitude and timing of these projected changes remains low3,4, leaving societies largely unprepared5,6. Here we show that constraining model projections with observations using a newly proposed emergent constraint (EC) reduces the uncertainty in predictions of a core drought indicator, the longest annual dry spell (LAD), by 10-26% globally. Our EC-corrected projections rev...
• Tackling antimicrobial resistance needs a tailored approach - four specialists weigh in AI翻译
  作者：Saha, Senjuti; Gales, Ana Cristina; Okeke, Iruka N.; Shamas, Nour
  作者单位：Universidade Federal de Sao Paulo (UNIFESP); University of Ibadan
  摘要：Ahead of a United Nations meeting on the global challenge of drug-resistant infections, Nature asked health-care experts in emerging economies to describe what would address the issue in their country or region most effectively. Ahead of a United Nations meeting on the global challenge of drug-resistant infections, Nature asked health-care experts in emerging economies to describe what would address the issue in their country or region most effectively.
• Birth of protein folds and functions in the virome AI翻译
  作者：Nomburg, Jason; Doherty, Erin E.; Price, Nathan; Bellieny-Rabelo, Daniel; Zhu, Yong K.; Doudna, Jennifer A.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley
  摘要：The rapid evolution of viruses generates proteins that are essential for infectivity and replication but with unknown functions, due to extreme sequence divergence1. Here, using a database of 67,715 newly predicted protein structures from 4,463 eukaryotic viral species, we found that 62% of viral proteins are structurally distinct and lack homologues in the AlphaFold database2,3. Among the remaining 38% of viral proteins, many have non-viral structural analogues that revealed surprising simila...
• Biotechnology A step towards protein sequencing by pores AI翻译
  作者：Aksimentiev, Aleksei
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign
• Menopause age shaped by genes that influence mutation risk AI翻译
  作者：Goriely, Anne
  作者单位：University of Oxford
• Linear symmetric self-selecting 14-bit kinetic molecular memristors AI翻译
  作者：Sharma, Deepak; Rath, Santi Prasad; Kundu, Bidyabhusan; Korkmaz, Anil; Harivignesh, S.; Thompson, Damien; Bhat, Navakanta; Goswami, Sreebrata; Williams, R. Stanley; Goswami, Sreetosh
  作者单位：Indian Institute of Science (IISC) - Bangalore; Texas A&M University System; Texas A&M University College Station; University of Limerick
  摘要：Artificial Intelligence (AI) is the domain of large resource-intensive data centres that limit access to a small community of developers1,2. Neuromorphic hardware promises greatly improved space and energy efficiency for AI but is presently only capable of low-accuracy operations, such as inferencing in neural networks3-5. Core computing tasks of signal processing, neural network training and natural language processing demand far higher computing resolution, beyond that of individual neuromor...
• Cultural evolution can help to interpret AI model collapse AI翻译
  作者：Smith, Kenny; Kirby, Simon; Guo, Shangmin; Griffiths, Thomas L.
  作者单位：University of Edinburgh; Princeton University
• The hepatitis C virus envelope protein complex is a dimer of heterodimers AI翻译
  作者：Augestad, Elias Honerod; Olesen, Christina Holmboe; Gronberg, Christina; Soerensen, Andreas; Velazquez-Moctezuma, Rodrigo; Fanalista, Margherita; Bukh, Jens; Wang, Kaituo; Gourdon, Pontus; Prentoe, Jannick
  作者单位：University of Copenhagen; Copenhagen University Hospital; University of Copenhagen; University of Copenhagen; Chinese Academy of Sciences; Lund University
  摘要：Fifty-eight million individuals worldwide are affected by chronic hepatitis C virus (HCV) infection, a primary driver of liver cancer for which no vaccine is available1. The HCV envelope proteins E1 and E2 form a heterodimer (E1/E2), which is the target for neutralizing antibodies2. However, the higher-order organization of these E1/E2 heterodimers, as well as that of any Hepacivirus envelope protein complex, remains unknown. Here we determined the cryo-electron microscopy structure of two E1/...
• The electrodynamic creep and flow of skyrmions AI翻译
  作者：Wu, Yingying
  作者单位：State University System of Florida; University of Florida
  摘要：Swirling magnetic structures move through a material in ways that depend on their interactions with mobile electrons. Fresh insight into how to control this electrodynamic effect could lead to ultracompact magnetic devices.