-
作者：Mallapaty, Smriti
摘要：The Pathoplexus database has sequences from Ebola, West Nile virus and another dangerous pathogen.
-
作者：Oei, Martijn S. S. L.; Hardcastle, Martin J.; Timmerman, Roland; Gast, Aivin R. D. J. G. I. B.; Botteon, Andrea; Rodriguez, Antonio C.; Stern, Daniel; Calistro Rivera, Gabriela; van Weeren, Reinout J.; Roettgering, Huub J. A.; Intema, Huib T.; de Gasperin, Francesco; Djorgovski, S. G.
作者单位：Leiden University; Leiden University - Excl LUMC; California Institute of Technology; University of Hertfordshire; Durham University; University of Oxford; Istituto Nazionale Astrofisica (INAF); California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); European Southern Observatory; Helmholtz Association; German Aerospace Centre (DLR)
摘要：When sustained for megayears (refs. 1,2), high-power jets from supermassive black holes (SMBHs) become the largest galaxy-made structures in the Universe3. By pumping electrons, atomic nuclei and magnetic fields into the intergalactic medium (IGM), these energetic flows affect the distribution of matter and magnetism in the cosmic web4-6 and could have a sweeping cosmological influence if they reached far at early epochs. For the past 50 years, the known size range of black hole jet pairs ende...
-
作者：Lentzsch, Alfred M.; Yudin, Denis; Gamerdinger, Martin; Chandrasekar, Sowmya; Rabl, Laurenz; Scaiola, Alain; Deuerling, Elke; Ban, Nenad; Shan, Shu-ou
作者单位：California Institute of Technology; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Konstanz
摘要：Approximately 40% of the mammalian proteome undergoes N-terminal methionine excision and acetylation, mediated sequentially by methionine aminopeptidase (MetAP) and N-acetyltransferase A (NatA), respectively(1). Both modifications are strictly cotranslational and essential in higher eukaryotic organisms(1). The interaction, activity and regulation of these enzymes on translating ribosomes are poorly understood. Here we perform biochemical, structural and in vivo studies to demonstrate that the...
-
作者：Soliman, Alix
摘要：Telling people about the consensus among scientists can help, study finds, but researchers think that personal conversations are needed, too.
-
作者：Shah, Hiral; Olivetta, Marine; Bhickta, Chandni; Ronchi, Paolo; Trupinic, Monika; Tromer, Eelco C.; Tolic, Iva M.; Schwab, Yannick; Dudin, Omaya; Dey, Gautam
-
作者：Shah, Hiral; Olivetta, Marine; Bhickta, Chandni; Ronchi, Paolo; Trupinic, Monika; Tromer, Eelco C.; Tolic, Iva M.; Schwab, Yannick; Dudin, Omaya; Dey, Gautam
作者单位：European Molecular Biology Laboratory (EMBL); Swiss Institute Experimental Cancer Research; Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; European Molecular Biology Laboratory (EMBL); University of Groningen
-
作者：Green, Gilad Sahar; Fujita, Masashi; Yang, Hyun-Sik; Taga, Mariko; Cain, Anael; McCcabe, Cristin; Comandante-Lou, Natacha; White, Charles C.; Schmidtner, Anna K.; Zeng, Lu; Sigalov, Alina; Wang, Yangling; Regev, Aviv; Klein, Hans-Ulrich; Menon, Vilas; Bennett, David A.; Habib, Naomi; De Jager, Philip L.
作者单位：Hebrew University of Jerusalem; NewYork-Presbyterian Hospital; Columbia University; NewYork-Presbyterian Hospital; Columbia University; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Rush University; Massachusetts Institute of Technology (MIT); Roche Holding; Genentech; Roche Holding USA
摘要：Alzheimer's disease (AD) has recently been associated with diverse cell states1-11, yet when and how these states affect the onset of AD remains unclear. Here we used a data-driven approach to reconstruct the dynamics of the brain's cellular environment and identified a trajectory leading to AD that is distinct from other ageing-related effects. First, we built a comprehensive cell atlas of the aged prefrontal cortex from 1.65 million single-nucleus RNA-sequencing profiles sampled from 437 old...
-
作者：Stankovic, Stasa; Shekari, Saleh; Huang, Qin Qin; Gardner, Eugene J.; Ivarsdottir, Erna V.; Owens, Nick D. L.; Mavaddat, Nasim; Azad, Ajuna; Hawkes, Gareth; Kentistou, Katherine A.; Beaumont, Robin N.; Day, Felix R.; Zhao, Yajie; Jonsson, Hakon; Rafnar, Thorunn; Tragante, Vinicius; Sveinbjornsson, Gardar; Oddsson, Asmundur; Styrkarsdottir, Unnur; Gudmundsson, Julius; Stacey, Simon N.; Gudbjartsson, Daniel F.; Kennedy, Kitale; Wood, Andrew R.; Weedon, Michael N.; Ong, Ken K.; Wright, Caroline F.; Hoffmann, Eva R.; Sulem, Patrick; Hurles, Matthew E.; Ruth, Katherine S.; Martin, Hilary C.; Stefansson, Kari; Perry, John R. B.; Murray, Anna
作者单位：University of Cambridge; University of Exeter; University of Queensland; Wellcome Trust Sanger Institute; Decode Genetics; University of Cambridge; University of Copenhagen; University of Cambridge; University of Cambridge
摘要：Human genetic studies of common variants have provided substantial insight into the biological mechanisms that govern ovarian ageing1. Here we report analyses of rare protein-coding variants in 106,973 women from the UK Biobank study, implicating genes with effects around five times larger than previously found for common variants (ETAA1, ZNF518A, PNPLA8, PALB2 and SAMHD1). The SAMHD1 association reinforces the link between ovarian ageing and cancer susceptibility1, with damaging germline vari...
-
作者：Lynch, Charles J.; Elbau, Immanuel G.; Ng, Tommy; Ayaz, Aliza; Zhu, Shasha; Wolk, Danielle; Manfredi, Nicola; Johnson, Megan; Chang, Megan; Chou, Jolin; Summerville, Indira; Ho, Claire; Lueckel, Maximilian; Bukhari, Hussain; Buchanan, Derrick; Victoria, Lindsay W.; Solomonov, Nili; Goldwaser, Eric; Moia, Stefano; Caballero-Gaudes, Cesar; Downar, Jonathan; Vila-Rodriguez, Fidel; Daskalakis, Zafiris J.; Blumberger, Daniel M.; Kay, Kendrick; Aloysi, Amy; Gordon, Evan M.; Bhati, Mahendra T.; Williams, Nolan; Power, Jonathan D.; Zebley, Benjamin; Grosenick, Logan; Gunning, Faith M.; Liston, Conor
作者单位：Cornell University; Weill Cornell Medicine; Johannes Gutenberg University of Mainz; Stanford University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Geneva; University of Toronto; University of Toronto; University of British Columbia; University of California System; University of California San Diego; University of Toronto; Centre for Addiction & Mental Health - Canada; University of Minnesota System; University of Minnesota Twin Cities; Icahn School of Medicine at Mount Sinai; Washington University (WUSTL)
摘要：Decades of neuroimaging studies have shown modest differences in brain structure and connectivity in depression, hindering mechanistic insights or the identification of risk factors for disease onset1. Furthermore, whereas depression is episodic, few longitudinal neuroimaging studies exist, limiting understanding of mechanisms that drive mood-state transitions. The emerging field of precision functional mapping has used densely sampled longitudinal neuroimaging data to show behaviourally meani...
-
作者：Lee, Casey S.; Chen, Sisi; Berry, Corbett T.; Kelly, Andre R.; Herman, Patrick J.; Oh, Sangwook; O'Connor, Roddy S.; Payne, Aimee S.; Ellebrecht, Christoph T.
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Hallym University; Columbia University
摘要：Early expansion and long-term persistence predict efficacy of chimeric antigen receptor T cells (CARTs)1-7, but mechanisms governing effector versus memory CART differentiation and whether asymmetric cell division induces differential fates in human CARTs remain unclear. Here we show that target-induced proximity labelling enables isolation of first-division proximal-daughter and distal-daughter CD8 CARTs that asymmetrically distribute their surface proteome and transcriptome, resulting in div...
