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作者：Schaeffer, Nathanael; Labrosse, Stephane; Aurnou, Jonathan M.
作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Savoie Mont Blanc; Institut de Recherche pour le Developpement (IRD); Universite Gustave-Eiffel; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Lyon 1; University of California System; University of California Los Angeles
摘要：Previous studies focusing on the electrical conductivity and thermal evolution of an early magma ocean at the base of Earth's mantle have found that basal magma ocean (BMO) convection could have produced the ancient geomagnetic field. By advances in high-resolution dynamo modeling, we find that convection in a thin BMO-like spherical shell is able to sustain strong magnetic fields, including axial dipolar fields similar to current day field structure. However, integrating our dynamo results wi...
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作者：Wang, Zhanchun; Yu, Shibo; Xu, Wencai; Peng, Han; Zhou, Xuan; Liese, Anja; Chen, Lilan; Zhong, Guitao; Zhong, Chen; Deng, Xianya; Han, Libo; Liu, Na; Lee, Justin; Romeis, Tina; Tang, Dingzhong; Wang, Wei
作者单位：Fujian Agriculture & Forestry University; Fujian Agriculture & Forestry University; Fujian Agriculture & Forestry University; Fujian Agriculture & Forestry University; Leibniz Institut fur Pflanzenbiochemie; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS
摘要：Calcium (Ca2+) signaling plays a crucial role in plant immunity, regulating both pattern-triggered immunity (PTI) through cell-surface receptors and effector-triggered immunity (ETI) via intracellular nucleotide-binding, leucine-rich repeat receptors (NLRs). Calcium-dependent protein kinases (CPKs/CDPKs) serve as key Ca2+ sensors and signal transducers in these processes. In this study, we demonstrate the relevance of two rice CPKs, OsCPK5 and OsCPK13, for rice blast resistance. Both are Ca2+-...
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作者：Young-Brun, Marie; Dennig, Francis; Errickson, Frank; Feindt, Simon; Mejean, Aurelie; Zuber, Stephane
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作者：Podar, Peter T.; Bolmatov, Dima; Kumarage, Teshani; Ashkar, Rana; Adkisson, Ariana; Ziemer, Olivia; Sullivan, Victoria; Mohamed, Ahmed S.; Najem, Joseph. S.; Collier, C. Patrick; Katsaras, John
作者单位：University of Tennessee System; United States Department of Energy (DOE); University of Tennessee Knoxville; Oak Ridge National Laboratory; University of Tennessee System; University of Tennessee Knoxville; Vanderbilt University; University of Illinois System; University of Illinois Urbana-Champaign; Texas Tech University System; Texas Tech University; University of Illinois System; University of Illinois Urbana-Champaign; Virginia Polytechnic Institute & State University; Virginia Polytechnic Institute & State University; Louisiana State University System; Louisiana State University; University of Tennessee System; University of Tennessee at Chattanooga; University of Tennessee System; University of Tennessee Knoxville; United States Department of Energy (DOE); Oak Ridge National Laboratory; Center for Nanophase Materials Sciences; United States Department of Energy (DOE); Oak Ridge National Laboratory
摘要：Human neural networks of interconnected neurons have evolved to be remarkably efficient and are capable of learning and memory through the brain's synaptic plasticity, including short-term plasticity (STP), and long-term potentiation (LTP) and depression (LTD). These activity-dependent mechanisms induce changes in synaptic efficiency over both transient and extended timescales. Understanding the molecular basis of learning and memory is central to deciphering brain function and advancing thera...
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作者：Song, Kefan; Nguyen, Dinh Chuong; Wang, Yonghui; Jokonya, Simbarashe; Yazdani, Omeed; Sellers, Drew L.; Stayton, Patrick S.; Pun, Suzie H.
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Peptide therapeutic cancer vaccines are an attractive treatment modality for their safety and manufacturability but have been hindered in clinical translation by low immunogenicity and insufficient CD8+T cell activation. We developed virus-inspired polymers for endosomal release (VIPER) to address systemic and intracellular delivery obstacles, but durable antitumor immunity remained elusive. Adjuvants stimulating innate immunity, such as stimulator of interferon genes (STING) agonists, can enh...
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作者：Golden, Susan S.; DeRosier, David J.; Dahlberg, James E.; Sherman, Louis A.; Brahamsha, Bianca
作者单位：University of California System; University of California San Diego; Brandeis University; University of Wisconsin System; University of Wisconsin Madison; Purdue University System; Purdue University
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作者：Mahajan, Akanksha S.; Dussold, Corey; Kim, Seunghyun; Jarvis, Rachel; Hurley, Lisa A.; Tommasini-Ghelfi, Serena; Park, Jungsoo; Forsyth, Connor M.; Zhang, Bin; Miska, Jason; Heimberger, Amy B.; Mirkin, Chad A.; Stegh, Alexander H.
作者单位：Siteman Cancer Center; Northwestern University; Feinberg School of Medicine; Northwestern University; Robert H. Lurie Comprehensive Cancer Center; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine; Northwestern University
摘要：The cyclic GMP-AMP synthase-Stimulator of Interferon Genes (cGAS-STING) pathway is an important DNA-sensing mechanism that increases T cell trafficking and activation in tumors and reverses the immunosuppressive phenotype of myeloid cells. Therefore, direct STING targeting using synthetic cyclic dinucleotides (CDNs) is an attractive strategy for treating lymphocyte-depleted and myeloid cell-enriched tumors, such as glioblastoma (GBM). However, inadequate bioavailability and poor cellular accum...
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作者：Teets, Emily; Singhvi, Aakanksha
作者单位：Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center
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作者：Hang, Xudong; Zhang, Lin; Huang, Yanqiang; Hu, Yuanyuan; Zeng, Qi; Cronan, John E.; Zhang, Liang; Bi, Hongkai
作者单位：Hainan Medical University; Shanghai Jiao Tong University; Youjiang Medical University for Nationalities; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Shanghai Jiao Tong University
摘要：The beta- ketoacyl-acyl carrier protein (ACP) synthases are pivotal elongation enzymes that catalyze the condensation of acyl-CoA or acyl-ACP with malonyl-ACP to produce beta- ketoacyl-ACP. Among these, the homologous enzymes FabH (beta- ketoacyl-ACP synthase III) and the recently characterized BioZ play crucial roles, initiating the biosynthetic pathways for fatty acids and biotin, respectively. FabH primarily utilizes acetyl-CoA as the primer substrate, whereas BioZ exclusively condenses the...
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作者：Hazime, Khodor S.; Sheppard, Sam; Niembro-Vivanco, Olatz; Hosty, Cathal; Thomas, Heather; Loosbroock, Christopher; Peiser, Leanne; Davis, Daniel M.
