45期

最新文章

• Structural basis for a potent human neutralizing antibody targeting a conserved epitope on the H7 hemagglutinin head AI翻译
  作者：Li, Junxin; Wang, Min; Yang, Yang; Zhang, Limin; Liu, Lvyan; Yang, Wei; Peng, Yun; Zhang, Xu; Yuan, Bin; Peng, Qi; Yang, Xiaolu; Chen, Yixin; Gao, George F.; Shi, Yi; Wan, Xiaochun
  作者单位：Chinese Academy of Sciences; Guangzhou Laboratory; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Microbiology, CAS; Southern University of Science & Technology; Xiamen University; Shenzhen Maternity & Child Healthcare Hospital; Southern Medical University - China; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; State Key Laboratory of Respiratory Disease; Guangzhou Medical University; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine
  摘要：Zoonotic H7N9 avian influenza virus infection remains a global concern because of its pandemic potential. Therefore, developing effective antibodies and vaccines against H7N9 is vital for preventing and controlling major outbreaks. Here, we isolated a human VH3-30 gene-encoded antibody, designated 6Y13, from a survivor of H7N9 infection. This antibody recognized the hemagglutinins (HAs) of the representative H7 subtype zoonotic viruses spanning two decades of antigenic evolution and potently n...
• Restoration of cGAS in cancer cells promotes antitumor immunity via transfer of cancer cell-generated cGAMP AI翻译
  作者：Cryer, Alexander M.; Dosta, Pere; Dion, Michelle Z.; Soto, Leonardo de la Parra; Amar-lewis, Eliz; Carmona, Gabriela Garcia de Leon; Perez, Alejandro Abraham Espinosa; Aguilar, Diego Fernando Ruiz; Huerta, Triana; Ruiz, Beatriz Nicolas; Hernandez, Nathalie Nicole Casteele; Soria, Yael; Artzi, Natalie
  作者单位：Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University
  摘要：Cancer cells comprise a significant proportion of the tumor microenvironment (TME) and often have compromised expression or repression of cyclic GMP- AMP (cGAMP) synthase (cGAS), which prevents effective stimulation of interferon genes (STING) signaling. Here, we leverage the cancer cells and hijack their cellular machinery for increased production of cGAMP, differing from conventional strategies whereby synthetic STING agonists are delivered to immune cells in the TME as a bolus dose, are rap...
• MDFIC2 is a PIEZO channel modulator that can alleviate mechanical allodynia associated with neuropathic pain AI翻译
  作者：Habib, Abdella M.; Li, Shengnan; Zhang, Chenjing; Ji, Meijun; Osorio, Nancy; Penalba, Virginie; Torres, Jesus M.; Gossage, Samuel J.; Rezai, Mehdi A.; Geard, Amy F.; Rahim, Ahad A.; Mahmoud, Ahmed M. M.; Santana-Varela, Sonia; Zhou, Jun; Zhao, Jing; Wood, John N.; Okorokov, Andrei L.; Zhou, Xuelong; Cox, James J.; Coste, Bertrand
  作者单位：Qatar University; University of London; University College London; Hangzhou Medical College; Zhejiang Provincial People's Hospital; INRAE; Aix-Marseille Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); University of Granada; University of London; University College London; University of London School of Pharmacy; Egyptian Knowledge Bank (EKB); Assiut University; Wuhan University; Zhejiang University; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS)
  摘要：PIEZO channels are mechanical force sensors involved in various biological processes, including somatosensation. To date, only a few PIEZO- binding partners have been identified, including MyoD- family inhibitor proteins (MDFI and MDFIC). Here, we show that MDFIC2, a third member of the MDFI protein family with an as- yet- unknown function, is expressed in a subset of nociceptive sensory neurons. MDFIC2 modulates both PIEZO1 and PIEZO2 gating properties by slowing their kinetics and shifting m...
• Genomics of sorghum local adaptation to a parasitic plant (vol 117, pg 4243, 2020) AI翻译
  作者：Bellis, Emily S.; Kelly, Elizabeth A.; Lorts, Claire M.; Gao, Huirong; DeLeo, Victoria L.; Rouhan, Germinal; Budden, Andrew; Bhaskara, Govinal B.; Hu, Zhenbin; Muscarella, Robert; Timko, Michael P.; Nebie, Baloua; Runo, Steven M.; Chilcoat, N. Doane; Juenger, Thomas E.; Morris, Geoffrey P.; dePamphilis, Claude W.; Lasky, Jesse R.
• The RANK/RANKL axis controls vascular dynamics in the bone marrow AI翻译
  作者：Kaneko, Takeshi; Yari, Shinya; Kikuta, Junichi; Omatsu, Yoshiki; Seno, Shigeto; Kikuchi, Sumire; Sato, Kazuma; Fujii, Kentaro; Sudo, Takao; Hasegawa, Tetsuo; Furuta, Kunimaro; Guo, Qianqian; Ibrahim, Samar H.; Muraoka, Kosuke; Okada, Yoshiaki; Kubota, Yoshiaki; Okuzaki, Daisuke; Kobayashi, Yasuhiro; Kumanogoh, Atsushi; Udagawa, Nobuyuki; Nagasawa, Takashi; Penninger, Josef M.; Ishii, Masaru
  作者单位：University of Osaka; University of Osaka; University of Osaka; University of Osaka; University of Osaka; Mayo Clinic; University of Osaka; Keio University; University of Osaka; Matsumoto Dental University; Helmholtz Association; Helmholtz-Center for Infection Research; Medical University of Vienna; University of British Columbia; University of Osaka; Kobe University
  摘要：Receptor activator of nuclear factor kappa B ligand (RANKL) is an essential cytokine that induces osteoclastic differentiation by monocyte-macrophage lineage precursors. Here, we showed that in addition to its conventional action, RANKL controls vascular permeability in the bone marrow, where it facilitates the mobilization of hematopoietic monocytic cells, including osteoclast precursors, and resultantly regulates bone metabolism. RANK, a cognate receptor for RANKL, is abundantly expressed in...
• Direct and in situ examination of Li+ transport kinetics in an isotope- labeled solid-electrolyte interphase AI翻译
  作者：Yu, Xiaofei; Angarita-Gomez, Stefany; Xu, Yaobin; Gao, Peiyuan; Wang, Jun-Gang; Zhang, Xin; Song, Minyung; Jia, Hao; Xu, Wu; Li, Xiaolin; Kao, Hsin-Mei; Du, Yingge; Xu, Zhijie; Ho, Janet S.; Xu, Kang; Balbuena, Perla B.; Wang, Chongmin; Zhu, Zihua
  作者单位：SES AI Corporation; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Texas A&M University System; Texas A&M University College Station; United States Department of Energy (DOE); Pacific Northwest National Laboratory; United States Department of Energy (DOE); Pacific Northwest National Laboratory; United States Department of Defense; United States Army; US Army Research, Development & Engineering Command (RDECOM); US Army Research Laboratory (ARL)
  摘要：Solid-electrolyte interphase (SEI) is the critical component in all advanced battery chemistries, whose ionic transport and electron leakage behaviors remain least understood among all battery components. Here, using unique in situ liquid secondary ion mass spectroscopy on isotope-labeled SEI, assisted by cryogenic transmission electron microscopy and constrained ab initio molecular dynamics simulation, we answer the question regarding the Li+ transport mechanism across SEI and quantitatively ...
• Long-chain unsaturated free fatty acids control gut motility via nitrergic ganglia of the enteric nervous system AI翻译
  作者：Zhang, Jun-Hao; Jiang, Zhi-Hui; Xuan, Ji; Liao, Yang; Li, Peng-Peng; Wang, Ye; Wang, Han; Qiu, Tian-Tian; Chen, Ze-Xu; Qiu, Ke-Hui; Zhou, Yu-Wei; Ye, Jing-Xin; Gong, Jian-Feng; Jiang, Jun; Ni, Ling; Ma, Hong-Feng; Zhang, Xue-Na; Chen, Hua-Qun; Zhu, Min-Sheng; Chen, Xin
  作者单位：Nanjing University; Nanjing University; Nanjing University; Nanjing University; Nanjing University; Nanjing Normal University
  摘要：Although mechanical tension from luminal distension is a primary regulator of gut motility, we reveal a parallel chemosensory pathway wherein long- chain unsaturated free fatty acids (LUFFAs) from dietary or enterobacterial sources directly modulate gastrointestinal motor function. Using ex vivo and in vivo contractility assays in human and murine intestaneous contractions and delayed intestinal transit in a double bond- dependent manner. Mechanistically, selective activation of free fatty aci...
• Impact of biomanufacturing protein fibers on achieving sustainable development AI翻译
  作者：Allen, Benjamin D.; Ghotra, Baljit; Kosan, Birgit; Kohler, Philipp; Krieg, Marcus; Kindler, Christoph; Sturm, Michael; Demirel, Melik C.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
  摘要：Biomanufactured fibers produced through fermentation processes provide a promising pathway to decouple textile production from agricultural land. This would free up arable land for food cultivation and contribute to the United Nations Sustainable Development Goal 2: Zero Hunger. Protein fibers from natural sources such as cocoon silk, collagen, and soy have attracted attention since the last century. However, commercial production declined with the rise of cheaper synthetic fibers and competit...
• Relationship dynamics and behavioral adaptations in the control of the 2022 mpox epidemic (vol 122, e2502861122, 2025) AI翻译
  作者：Hvid, Ulrik; Simonsen, Lone; Frisch, Morten; Sneppen, Kim
• Local control of T cell fate in lymph nodes safely and durably reverses myelin-driven autoimmunity AI翻译
  作者：Kapnick, Senta M.; Gosselin, Emily A.; Tsai, Shannon J.; Oakes, Robert S.; Habibabady, Zahra A.; Ackun-Farmmer, Marian A.; Carey, Sean T.; Shah, Shrey A.; Shen, Ruochen; Froimchuk, Eugene; Eppler, Haleigh B.; Bridgeman, Christopher J.; Yanes, Alexis A.; Mcilvaine, Ryan A.; Noshin, Maeesha; Tostanoski, Lisa H.; Black, Sheneil K.; Zeng, Xiangbin; Azimzadeh, Agnes; Pierson III, Richard N.; Bromberg, Jonathan S.; Jewell, Christopher M.
  作者单位：University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore
  摘要：Development of tolerogenic, antigen-specific immunotherapies could overcome limitations of existing treatments for inflammatory autoimmune diseases by achieving potent, durable remission without impacting healthy immune surveillance. Here, we deliver diffusion-limited polymer depots to lymph nodes to locally guide T cell fates for the treatment of multiple sclerosis (MS), an autoimmune disease that occurs when the immune system mistakenly attacks myelin. In preclinical MS models, depots loaded...