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作者：Sun, Mengze; Lu, Baiyan; Yang, Ying; Fan, Junping; Ren, Weiwei; Chu, Xiaonan; Gao, Yihui; Wu, Jun; Wang, Jue; Ke, Han; Liu, Zhiwen; Dai, Shaojun; Lei, Xiaoguang; Li, Chao
作者单位：Peking University; Peking University; East China Normal University; Shanghai Normal University; Shenzhen Bay Laboratory; East China Normal University
摘要：Since its initial identification as the receptor for Rapid Alkalinization Factor 1 (RALF1), FERONIA (FER) receptor kinase has emerged as a central signaling hub coordinating plant development, stress adaptation, and immune responses. Nevertheless, fundamental questions persist regarding the precise mechanisms of FER-mediated signal transduction and its context-dependent functional specialization in multicellular processes. Here, we develop Ferovicin (FRY), a small-molecule inhibitor that speci...
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作者：Zhang, Zhen; Xie, Zhengcheng; Kob, Walter
作者单位：Chengdu University of Technology; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS)
摘要：Silica is the paradigmatic network glass-former and understanding its response to pressure is essential for comprehending the mechanical properties of silica-based materials and the behavior of silicate melts in the Earth's interior. While pressure (P)-induced changes in the short-range structure-particularly the breakdown of tetrahedral symmetry-have been well documented, structural transformations on larger length scales, important for many material properties, remain poorly understood. Here...
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作者：Natrajan, Maanasa; Fitzgerald, James E.
作者单位：Northwestern University; Johns Hopkins University; Johns Hopkins Medicine; Howard Hughes Medical Institute; Northwestern University; Northwestern University
摘要：Memories are believed to be stored in synapses and retrieved by reactivating neural ensembles. Learning alters synaptic weights, which can interfere with previously stored memories that share the same synapses, creating a trade-off between plasticity and stability. Interestingly, neural representations change even in stable environments, without apparent learning or forgetting-a phenomenon known as representational drift. Theoretical studies have suggested that multiple neural representations ...
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作者：Zhou, Xinying; Spengler, Robert N.; Sayfullaev, Bahediyoh; Mutalibjon, Khasanov; Ma, Jian; Liu, Junchi; Shen, Hui; Zhao, Keliang; Chen, Guanhan; Wang, Jian; Stidham, Thomas A.; Xu, Hai; Zhang, Guilin; Yang, Qingjiang; Hou, Yemao; Ma, Jiacheng; Kambarov, Nasibillo; Jiang, Hongen; Maksudov, Farhod; Goldstein, Steven; Wang, Jianxin; Fuller, Dorian Q.; Li, Xiaoqiang
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作者：Gentry, Kara; Lian, Liming; Kim, Hyejin; Celik, Ozgenur; Jones, Camille; Podilapu, Ananda R.; Shakked, Avraham; Loughrey, David; Zenhausern, Ryan; Jang, Bora; Doan, Jessie; Rudden, Sebastian; Dahlman, James E.; Coulter, Wallace H.
作者单位：Emory University; University System of Georgia; Georgia Institute of Technology
摘要：Lipid nanoparticles (LNPs) formulated with a neutral helper lipid can deliver RNA to the liver in humans. However, clinically relevant delivery to other tissues has remained challenging. To avoid the liver, scientists often add antibodies or helper lipids with a permanent charge. Here, we report an alternative approach: antibody- and charge- independent liver detargeting. Using DNA barcoding to test 109 chemically distinct LNPs in vivo, we found that replacing a neutral helper lipid with a neu...
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作者：Lin, Mingjun; Li, Guanya; Tang, Xinyu; Li, Ru; Li, Yinan; Wang, Lijie; Xu, Zeyu; Liu, Liansheng; Ju, Enguo; Shang, Jian; He, Shanping; Li, Tingting
作者单位：Hunan Normal University; Zhengzhou University; Guangzhou Laboratory; Sun Yat Sen University
摘要：Metabolic pathways are typically dysregulated in cancer to support critical cellular processes. In response to metabolic disturbances, cancer cells preferentially manipulate stress sensors to enhance their adaptability. Sestrin 2 (SESN2), a highly conserved protein induced by various stressors, is implicated in this adaptation. Mutations and alterations of SESN2 are prevalent among cancer patients, suggesting a potential role in tumor progression. However, the functions and regulation of SESN2...
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作者：Su, Buxin; Su, Weijie J.; Wang, Chendi
作者单位：University of Pennsylvania; University of Pennsylvania; Xiamen University; Xiamen University; Xiamen University
摘要：The US Decennial Census serves as the foundation for many high-profile policy decision-making processes, including federal funding allocation and redistricting. In 2020, the Census Bureau adopted differential privacy to protect the confidentiality of individual responses through a disclosure avoidance system that injects noise into census data tabulations. The Bureau subsequently posed an open question: Could stronger privacy guarantees be obtained for the 2020 US Census compared to their publ...
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作者：Yang, Xuyu; Lee, Joo-Youn; Moghadam, Farbod; Steiner, Joseph; Kim, Soo-Kyung; Ganjur, Neha; De Almenara, Adrian J.; Stoltz, Brian M.; Loh, Y. Peng; Goddard, William A., III
作者单位：National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); California Institute of Technology; Korea Research Institute of Chemical Technology (KRICT); California Institute of Technology; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
摘要：Alzheimer neurodegenerative disease (AD) has had a major impact worldwide, with no effective drugs for treatment. We discovered and reported earlier that neurotrophic factor-alpha 1 (NF-alpha 1)/carboxypeptidase E (CPE) reversed neurodegeneration and cognitive dysfunction in AD mouse models. We then predicted computationally and validated experimentally that CPE interacts with a pharmacophore of six residues on the 5-HT1E receptor (HTR1E) to activate the ERK-BCL2 signaling pathway leading to p...
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作者：Sun, Xingwei; Feng, Yang; Yu, Jiangtao; Lu, Yong; Xu, Shuo; Jiang, Ying; Li, Haixia; Yan, Zhenhua; Zhang, Kai; Chen, Jun
作者单位：Tianjin University; Nankai University; Collaborative Innovation Center of Chemical Science & Engineering Tianjin
摘要：Lithium metal is widely recognized as the ultimate anode material for next-generation lithium batteries due to its superior specific capacity. However, microscopic crystallographic heterogeneity caused by crystal faces and grain boundaries leads to nonuniform lithium deposition, thereby undermining the stability of lithium metal anode. This study systematically investigates the intricate impact of grain boundaries on the structural characteristics, deposition behavior, and electrochemical prop...
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作者：Haas, Cyrus M.; Jasti, Naveen; Dosey, Annie; Allen, Joel D.; Gillespie, Rebecca; Mcgowan, Jackson; Leaf, Elizabeth M.; Crispin, Max; DeForest, Cole A.; Kanekiyo, Masaru; King, Neil P.
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Southampton; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Self-assembling protein nanoparticles are being increasingly utilized in the design of next-generation vaccines due to their ability to induce antibody responses of superior magnitude, breadth, and durability. Computational protein design offers a route to nanoparticle scaffolds with structural and biochemical features tailored to specific vaccine applications. Although strategies for designing self-assembling proteins have been established, the recent development of powerful machine learning ...
