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作者：Chadwick Jr, William W.
作者单位：Oregon State University
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作者：Liu, Junwei; Rogg, Manuel; Moos, Katharina; Sasanpour, Shaya; Strassl, Vera; Jain, Manaswita; Magassa, Sato; Neubauer, Bjorn; Braeg, Simone; Saller, Benedikt S.; Weisser, Lisa; Bienaime, Frank; Gorka, Oliver; Boerries, Melanie; Viau, Amandine; Gross, Olaf; Schell, Christoph; Kuehn, E. Wolfgang
作者单位：University of Freiburg; University of Freiburg; University of Freiburg; University of Freiburg; University of Freiburg; University of Freiburg; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; University of Freiburg; Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ); University of Freiburg; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); University of Freiburg; University of Freiburg; University of Freiburg; University of Freiburg
摘要：Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease. Limited treatment options lead to renal failure in the vast majority of affected individuals. Novel therapeutic approaches are needed. Recent evidence has identified inflammation as an important driver of ADPKD. We analyzed transcriptional profiles in an orthologous Pkd1 mouse model and found a strong upregulation of the inflammasome pathway. To investigate the role of inflammasomes on cyst formatio...
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作者：Mussini, Giovanni; Butterfield, Nicholas J.
作者单位：University of Cambridge
摘要：The Ordovician saw one of the greatest evolutionary radiations in the Earth's history, precipitating the assembly of modern animal-dominated ecologies in the aftermath of the Cambrian Explosion. However, Ordovician nonmineralized faunas are rare and mostly sample ecologically marginal settings. We describe small carbonaceous fossils (SCFs), including semiarticulated elements preserving submicrometric detail, from epicratonic deposits of the Deadwood and Winnipeg formations (ND). The Osterberg ...
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作者：Zhang, Christopher; Ratcliff, William C.
作者单位：University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology
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作者：Clark, Rene D.; Reid, Brendan N.; Garcia, Eric; Malabag, Marial; Waples, Robin S.; Abesamis, Rene A.; Baldisimo, Jemelyn Grace P.; Bucol, Abner A.; Fitz, Kyra S.; Magnuson, Sharon F.; Muallil, Richard N.; Nanola, Cleto L., Jr.; Roberts, Roy; Whalen, John C.; Bird, Christopher E.; Carpenter, Kent E.; Pinsky, Malin L.
作者单位：Drexel University; Rutgers University System; Rutgers University New Brunswick; University of California System; University of California Santa Cruz; University of Namur; Old Dominion University; University of Washington; University of Washington Seattle; University of the Philippines System; University of the Philippines Diliman; Silliman University; Tunghai University; Academia Sinica - Taiwan; Mindanao State University System; Mindanao State University-TCTO; University of the Philippines System; University of the Philippines Mindanao
摘要：Genetic diversity is a crucial component of biodiversity, and as such, its maintenance and preservation is of high conservation concern. Tropical environments are undergoing intense rates of environmental change, and these changes may be driving large declines in genetic diversity. However, data on genetic diversity are highly skewed towards temperate regions. The degree to which diversity loss has occurred in tropical species, particularly marine species, remains an open and important questio...
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作者：Michael, Nina; Huang, Bridget Y.; Ray, Korak Kumar; Kinz-Thompson, Colin D.; Gonzalez, Ruben L.
作者单位：Columbia University; Rutgers University System; Rutgers University Newark
摘要：Peptide release factor 2 (RF2) catalyzes the release of the nascent polypeptide chain from the bacterial ribosomal complex during translation termination and a subset of ribosome rescue pathways. Despite its critical role, the mechanisms that govern RF2 function and regulation remain elusive. Here, using single-molecule fluorescence resonance energy transfer, we characterize the conformational landscape that RF2 explores on the ribosomal complex and show that RF2 binding and dissociation from ...
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作者：Wu, Huiqiong; Duclut, Charlie; Arkowitz, Gregory; Chilupuri, Ranjith; Dang, Tien; Prost, Jacques; Ladoux, Benoit; Mege, Rene-Marc
作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); UNICANCER; Sorbonne Universite; Universite PSL; CNRS - Institute of Chemistry (INC); Institut Curie; University of Erlangen Nuremberg; Max Planck Society
摘要：Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties of extracellular matrix, a interesting mechanobiological paradigm highlights the role of osmotic and mechanical pressures in shaping epithelial tissues. In our study, we developed an in vitro model of cell-coated microsized hydrogel spheres (MHSs) which allows to decipher the interplay between cell...
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作者：Kapitan, Mario; Niemiec, Maria Joanna; Millet, Nicolas; Brandt, Philipp; Chowdhury, Estiak Khan; Czapka, Anna; Abdissa, Ketema; Hoffmann, Franziska; Lange, Anna; Veleba, Mark; Etzsche, S.; Mosig, Alexander S.; Loffler, Bettina; Marquet, Mike; Makarewicz, Oliwia; Kline, Kimberly A.; Vylkova, Slavena; Swidergall, Marc; Jacobsen, Ilse D.
作者单位：Leibniz Association; Hans Knoll Institute (HKI); Friedrich Schiller University of Jena; Friedrich Schiller University of Jena; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; Friedrich Schiller University of Jena; Leibniz Association; Hans Knoll Institute (HKI); Eberhard Karls University of Tubingen; Eberhard Karls University Hospital; Nanyang Technological University; Friedrich Schiller University of Jena; Friedrich Schiller University of Jena; Friedrich Schiller University of Jena; University of Geneva; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Friedrich Schiller University of Jena
摘要：The fungus Candida albicans and the Gram- positive bacterium Enterococcus faecalis share mucosal niches in the human body. As opportunistic pathogens, both are found to expand population size during dysbiosis, and can cause severe systemic infections in susceptible individuals. Here, we show that the presence of C. albicans results in increased host cell damage by E. faecalis. Furthermore, E. faecalis aggravates oropharyngeal candidiasis in mice. Increased damage is mediated by enterococcal cy...
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作者：Duppe, Nadine; Knauer, Lukas; Hagebolling, Marc; Langner, Lena; Stumpfig, Martin; Schunemann, Volker; Pierik, Antonio J.; Netz, Daili J.
作者单位：RPTU University Kaiserslautern; RPTU University Kaiserslautern; Philipps University Marburg; Philipps University Marburg; BioNTech SE
摘要：Mak16 and its interacting partner Rpf1 play a critical role at an early step in the maturation of the ribosomal 60S subunit of eukaryotes, as revealed by cryoelectron microscopy structures. While these studies suggested no metal participation or the presence of a Zn2+ ion in Mak16, we identify a previously unexplored iron-sulfur (Fe/S) cluster in yeast Mak16 through both in vivo and in vitro methods. We demonstrate a functional link between mitochondrial and cytosolic Fe/S protein biogenesis a...
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作者：Wang, Ning; Chien, Shu; Schwartz, Martin A.
作者单位：Northeastern University; Northeastern University; University of California System; University of California San Diego; University of California System; University of California San Diego; Yale University; Yale University; Yale University
摘要：Two recent conferences on mechanotransduction in biology and medicine showcased remarkable progress in this field and the potential for bringing mechanobiology into the clinic. In this Perspective, we discuss recent advances, the conceptual frameworks needed to develop clinical tools based on mechanobiology, and prospects for the future.
