Mechanomedicine: Present state and future promise

• 成果类型: Article
• 署名作者: Wang, Ning; Chien, Shu; Schwartz, Martin A.
• 署名单位: Northeastern University; Northeastern University; University of California System; University of California San Diego; University of California System; University of California San Diego; Yale University; Yale University; Yale University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.2509566122
• 发表日期: 2025-11-18
• 页码: e2509566122
• 关键词: mechanotransduction; mechanobiology; mechanohealth; mechanodiagnostics; mechanotherapy; mechanotransduction; homeostasis; proteins; tension; reveals; cells

摘要

Two recent conferences on mechanotransduction in biology and medicine showcased remarkable progress in this field and the potential for bringing mechanobiology into the clinic. In this Perspective, we discuss recent advances, the conceptual frameworks needed to develop clinical tools based on mechanobiology, and prospects for the future.