Synergistic interactions between Candida albicans and cell damage

• 成果类型: Article
• 署名作者: Kapitan, Mario; Niemiec, Maria Joanna; Millet, Nicolas; Brandt, Philipp; Chowdhury, Estiak Khan; Czapka, Anna; Abdissa, Ketema; Hoffmann, Franziska; Lange, Anna; Veleba, Mark; Etzsche, S.; Mosig, Alexander S.; Loffler, Bettina; Marquet, Mike; Makarewicz, Oliwia; Kline, Kimberly A.; Vylkova, Slavena; Swidergall, Marc; Jacobsen, Ilse D.
• 署名单位: Leibniz Association; Hans Knoll Institute (HKI); Friedrich Schiller University of Jena; Friedrich Schiller University of Jena; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; Friedrich Schiller University of Jena; Leibniz Association; Hans Knoll Institute (HKI); Eberhard Karls University of Tubingen; Eberhard Karls University Hospital; Nanyang Technological University; Friedrich Schiller University of Jena; Friedrich Schiller University of Jena; Friedrich Schiller University of Jena; University of Geneva; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Friedrich Schiller University of Jena
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.2505310122
• 发表日期: 2025-11-18
• 页码: e2505310122
• 关键词: Candida albicans; Enterococcus faecalis; COINFECTION; cytolysin; co- infection; ENTEROCOCCUS-FAECALIS CYTOLYSIN; INTESTINAL EPITHELIAL-CELLS; INHIBITS HYPHAL MORPHOGENESIS; STREPTOCOCCUS-FAECALIS; AGGREGATION SUBSTANCE; BACTERIAL MICROBIOTA; PATHOGENICITY ISLAND; genetic-analysis; virulence; infections

摘要

The fungus Candida albicans and the Gram- positive bacterium Enterococcus faecalis share mucosal niches in the human body. As opportunistic pathogens, both are found to expand population size during dysbiosis, and can cause severe systemic infections in susceptible individuals. Here, we show that the presence of C. albicans results in increased host cell damage by E. faecalis. Furthermore, E. faecalis aggravates oropharyngeal candidiasis in mice. Increased damage is mediated by enterococcal cytolysin, and involves both physical interaction and altered glucose availability. Physical interaction promotes accumulation of bacteria on host cells, facilitating contact of cytolysin with host cells. Glucose depletion by the metabolic activity of the fungus sensitized host cells to cytolysin. This work illustrates how a complex interplay between fungi and bacteria can result in detrimental consequences for the host.