46期

最新文章

• A binary- distributed effector modulates fungal host preference for drosophilids by targeting a lineage- specific immune factor AI翻译
  作者：Luo, Yujuan; Sheng, Xinlu; Wei, Dongxiang; Song, Shuangxiu; Chen, Chen; Wu, Hongyun; Shang, Junmei; Wang, Chengshu
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; ShanghaiTech University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Unlike host-specific parasites, broad-spectrum pathogens often exhibit an enigmatic strain/race-level preference for infecting particular host species over others. Here, we identify a polymorphic effector (termed Bhe1) that exhibits a binary presence-absence distribution pattern among strains of the entomopathogenic fungus Beauveria bassiana. Gene deletion and overexpression in Bhe1-present strains revealed that this gene functions as a virulence factor against Drosophila species but dispensab...
• MC1R determines healing outcomes in acute and chronic cutaneous wounds AI翻译
  作者：Nawilaijaroen, Yonlada; Rocliffe, Holly R.; Austin-Williams, Shani; Krilis, Georgios; Dawson, Charlotte; Harijanto, Pruistinne; Pellicoro, Antonella; Zhou, Kanheng; Ji, Yubo; Bain, Connor A.; Kilpatrick, Alastair M.; Chen, Yuhang; Biswas, Asok; Forbes, Shareen; Crichton, Michael; Huang, Zhihong; Forbes, Stuart J.; Caporali, Andrea; Cash, Jenna L.
  作者单位：University of Edinburgh; University of London; Queen Mary University London; University of Edinburgh; University of Dundee; Heriot Watt University; University of Edinburgh; University of Edinburgh
  摘要：Chronic wounds (CWs) represent a major clinical challenge, characterized by persistent inflammation and failed repair. While proresolving pathways are known to regulate inflammatory responses, their potential dysfunction in CWs remains unexplored. Here, we identify dysregulation of the pro-opiomelanocortin-melanocortin 1 receptor (POMC-MC1R) axis as a common feature across pressure ulcers, venous ulcers, and diabetic ulcers. Using MC1Re/e mice lacking functional MC1R, we demonstrate impaired w...
• A vasopressin circuit that modulates mouse social investigation and anxiety-like behavior in a sex-specific manner (vol 121, e2319641121, 2024) AI翻译
  作者：Rigney, Nicole; Campos-Lira, Elba; Kirchner, Matthew K.; Wei, Wei; Belkasim, Selma; Beaumont, Rachael; Singh, Sumeet; Suarez, Sara Guedez; Hartswick, Delenn; Stern, Javier E.; de Vries, Geert J.; Petrulis, Aras
• Electrokinetic nanoparticle transport in an interconnected porous environment: Decoupling cavity escape and directional bias AI翻译
  作者：Shi, Anni; Mirfendereski, Siamak; Gupta, Ankur; Schwartz, Daniel K.
  作者单位：University of Colorado System; University of Colorado Boulder
  摘要：Electrokinetic transport of nanoparticles in porous media is crucial for separation technologies, but the boundary-field coupling effects in three-dimensional (3D) interconnected porous spaces remain challenging to understand. Using superresolution 3D tracking of nanoparticles in interconnected cavities, we observed an unexpected disconnect between cavity escape time and directional bias as a function of electric field strength. The cavity escape times of individual nanoparticles decreased dra...
• How culturally wise psychological interventions can help reduce poverty AI翻译
  作者：Thomas, Catherine C.; Premand, Patrick; Bossuroy, Thomas; Sambo, Soumaila Abdoulaye; Markus, Hazel Rose; Walton, Gregory M.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Stanford University; The World Bank; The World Bank
  摘要：Poverty is characterized by multidimensional economic, social, and psychological constraints that undermine people's agency to pursue new opportunities and shape their life outcomes. How can interventions best support the agency of low-income individuals and, in so doing, boost poverty-reduction efforts? We theorize and find that agency interventions are effective when designed to be culturally wise, i.e., attuned to the model of agency predominant in a cultural context. Focusing on low-income...
• The Kinship Formula: Inferring the numbers of all kin from any structured population projection model AI翻译
  作者：Coste, Christophe F. D.
  作者单位：Swansea University; Norwegian Institute Nature Research; Norwegian University of Science & Technology (NTNU); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Museum National d'Histoire Naturelle (MNHN); CNRS - Institute of Ecology & Environment (INEE)
  摘要：Structured population projection models are fundamental to many fields of science. They enable abundance forecasting for populations categorized by various traits such as age (for demography), patch (for spatial ecology), genotype (for genetics), infectious stage (for epidemiology), or capital (economics). The demography of a structured population, determined by the transition rates (e.g., survival, fertility) between its various classes, also shapes its relatedness-or kinship-structure. This ...
• Therapeutic hypothermia reprograms nanocarrier protein corona via apolipoprotein C1 enrichment for precision cardiovascular therapy AI翻译
  作者：Li, Chenwen; Zhao, Guanli; Qi, Yuantong; Sun, Menglong; Zhong, Ling; Yang, Qinghua; Hu, Kaiyao; Cheng, Juan; Dou, Yin; Hao, Yingxue; Zhang, Jianxiang
  作者单位：Army Medical University; Army Medical University; Army Medical University
  摘要：Cardiovascular diseases (CVDs), the primary cause of global mortality, face persistent therapeutic challenges due to poor drug targeting and systemic side effects. While innovative nanotherapeutic approaches offer improved drug delivery through targeting and stimulus-responsive release mechanisms, clinical translation is limited by poor tissue specificity and manufacturing limitations. We present a universal therapeutic hypothermia (TH, i.e., 32 to 35 degrees C)-enhanced strategy that amplifie...
• Dissociation kinetics of G proteins from G protein-coupled receptors and effects of allosteric modulation AI翻译
  作者：Wang, Jinan; Nguyen, Anh T. N.; Adediwura, Victor A.; Lu, Cam Sinh; McNeill, Samantha M.; Jorg, Manuela; Scammells, Peter J.; Christopoulos, Arthur; May, Lauren T.; Miao, Yinglong
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; Monash University; Monash University; Monash University; Monash University
  摘要：G protein-coupled receptors (GPCRs), the largest superfamily of human membrane proteins with >800 members, are primary targets for similar to 1/3 of all marketed drugs. Recent fluorescence experiments underscored the pivotal role of GPCR-G protein complex lifetime in their coupling efficiency and selectivity. However, these experiments are often expensive, time-consuming, and limited to a small number of GPCR-G protein systems. On the other hand, it is challenging to simulate GPCR-G protein di...
• Design strategies for ion-sieving charge mosaic membranes toward sustainable lithium extraction AI翻译
  作者：Zhang, Ge; Hu, Guoliang; Li, Jinlei; Feng, Guangxia; Cui, Yi; Chen, Zhouyi; Liu, Zaichun
  作者单位：Stanford University; United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory; Stanford University
  摘要：Membrane-based technologies are essential for realizing sustainable ion-sieving processes such as lithium extraction. Much effort was devoted to designing new membrane materials, whereas the effect of charge distribution has been largely overlooked. Here, we filled this knowledge gap by providing a quantitative transport model for selective ion diffusion through a charge mosaic membrane (CMM). Composed of alternating regions of Li-selective ceramic and anion-selective polymeric materials, CMMs...