46期

最新文章

• PCNA is a nucleotide exchange factor for the clamp loader ATPase complex AI翻译
  作者：Pajak, Joshua; Landeck, Jacob T.; Liu, Xingchen; Anand, Krishna; Litvak, Sasha; Kelch, Brian A.
  作者单位：University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester
  摘要：All life requires loading ring-shaped sliding clamp protein complexes onto DNA. The sliding clamp loader is a conserved AAA+ ATPase that binds the sliding clamp, opens the ring, and places it onto DNA. While recent structural work on both the canonical and alternative clamp loaders has shed light into how these machines perform their task once, it remains unclear how clamp loaders are recycled to load multiple sliding clamps. Here, we present structures of the Saccharomyces cerevisiae clamp lo...
• PAK2-driven cytoskeleton-endosome dynamics control macrophage hyperphagia and SIRPA engagement AI翻译
  作者：La Rochelle, Julie Drieu; Cassidy, Joseph P.; Chernoff, Jonathan; Knaus, Ulla G.
  作者单位：University College Dublin; University College Dublin; Fox Chase Cancer Center
  摘要：Macrophages rely on dynamic cytoskeletal rearrangements to respond to their environment. This plasticity supports biomechanical transitions and functional polarization, mediating tissue homeostasis, antimicrobial defense, and repair processes. In the tumor environment context- specific reprogramming leads to functional diversification, from antitumorigenic to immunosuppressive phenotypes. Altering cytoskeletal dynamics modifies macrophage behavior and holds promise to shift their profile towar...
• Machine- learning models based on histological images from healthy donors identify imageQTLs and predict chronological age AI翻译
  作者：Meng, Ran; Zhu, William; Cameron, Christopher J. F.; Ni, Pengyu; Zhou, Xiao; Ulammandakh, Tselmeg; Gerstein, Mark B.
  作者单位：Yale University; Yale University; Yale University; Yale University; Yale University; Yale University
  摘要：Histological images offer a wealth of data. Mining these data holds significant potential for enhancing disease diagnosis and prognosis, though challenges remain, especially in noncancer contexts. In this study, we developed a statistical framework that links raw histological images and their derived features to the genotype, transcriptome, and chronological age of the samples. We first demonstrated an association between image features and genotypes, identifying 906 image quantitative trait l...
• Advancing stochastic 3-SAT solvers by dissipating oversatisfied constraints AI翻译
  作者：Schwardt, Joachim; Budich, Jan Carl
  作者单位：Max Planck Society; Technische Universitat Dresden
  摘要：We introduce and benchmark a stochastic local search heuristic for the Non-deterministic Polynomial Time (NP) complete satisfiability problem 3-SAT that drastically outperforms existing solvers in the notoriously difficult realm of critically hard instances. Our construction is based on the crucial observation that well established previous approaches such as WalkSAT are prone to get stuck in local minima that are distinguished from true solutions by a larger number of oversatisfied combinator...
• 撤稿声明: Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage AI翻译
  作者：Murmu, Nabendu; Jung, Jesse; Mukhopadhyay, Debnath; Houchen, Courtney W.; Riehl, Terrence E.; Stenson, William F.; Morrison, Aubrey R.; Arumugam, Thiruvengadam; Dieckgraefe, Brian K.; Anant, Shrikant
• Emergent neuronal mechanisms mediating covert attention in convolutional neural networks AI翻译
  作者：Srivastava, Sudhanshu; Wang, William Yang; Eckstein, Miguel P.
  作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara
  摘要：Covert visual attention allows the brain to select different regions of the visual world without eye movements. Predictive cues of a target location orient covert attention and improve perceptual performance. In most computational models, researchers explicitly incorporate an attentional mechanism that alters processing at the attended location Here, we assess the emergent neuronal mechanisms of Convolutional Neural Networks (CNNs) that exhibit behavioral signatures of covert attention, despit...
• Pressure-induced redox reversal of iron and the distribution of elements in deep Earth AI翻译
  作者：Wang, Xiaoli; Feng, Xiaolei; Li, Jianfu; Lv, Yang; Ellis, Austin; Scott, Samantha; Pandit, Abhiyan; Khodagholian, Dalar; Hemley, Russell J.; Jackson, Matthew G.; Spera, Frank; Redfern, Simon A. T.; Miao, Maosheng
  作者单位：Yantai University; Nanyang Technological University; California State University System; California State University Northridge; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of California System; University of California Santa Barbara; Nanyang Technological University
  摘要：We demonstrate a remarkable change in the chemical bonding of iron under pressure that underlies the distribution of elements in the Earth's mantle and core. Using a massive-scale, first-principles study, we show that while reacting with p-block elements under increasing pressure from ambient to Earth core conditions, iron tends to reverse its redox nature, changing from an electron donor (reductant) to an electron acceptor (oxidant), and oxidizes many p-block elements. Such reverse redox prop...
• FZD7 expression marks mammary tumor-initiating cells AI翻译
  作者：Wu, Christina C. N.; De Luna, Naycari; Hairston, Erin; Jeffs, Erin D.; Key, Ashley; Adams, Stephen R.; Advani, Sunil J.; Gaasterland, Terry; Carson, Dennis A.; Willert, Karl
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Scripps Institution of Oceanography
  摘要：The WNT signaling pathway has long been implicated in tumorigenesis across multiple cancer types, including breast cancer. However, the complexity arising from the large number of WNTs and their receptors has made it challenging to pinpoint specific components driving tumor development. Using the MMTV- Wnt1 genetically engineered mouse model, which develops mixed- lineage mammary tumors resembling triple- negative breast cancer and composed of both basal and luminal subtypes, we identify the f...
• Neurodevelopmental disorder-linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3′→5′ trimming AI翻译
  作者：Savidge, Andrew; Zhang, Huaqun; Adhav, Vishal Annasaheb; Kehling, Audrey C.; Sim, Geunyoung; Shen, Zhangfei; Fu, Tian- Min; Nakanishi, Kotaro
  作者单位：University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute; University System of Ohio; Ohio State University; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester
  摘要：Mutations in Argonaute proteins (AGOs) cause Argonaute syndrome, a neurodevelopmental disorder (NDD), yet the underlying molecular mechanism remains unclear. We determined cryo-electron microscopy (cryo-EM) structures of wild-type (WT) AGO1 and the recurrent, severe causative Delta F180 mutant. AGO1(Delta F180) unexpectedly rearranges the hydrophobic core of the L1 domain to preserve the overall RNA-induced silencing complexes (RISC) architecture and recognize guide RNAs similarly to WT. Funct...
• High-energy impact and vapor recondensation history of the angrite parent body revealed by nickel isotopes AI翻译
  作者：Zhu, Ke; Yamaguchi, Akira; Sossi, Paolo A.; Bouvier, Audrey; Chen, Lu; Ni, Peng
  作者单位：China University of Geosciences; University of Bristol; Research Organization of Information & Systems (ROIS); National Institute of Polar Research (NIPR) - Japan; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Bayreuth; University of California System; University of California Los Angeles
  摘要：The angrite parent body (APB) is the most volatile-depleted among known differentiated bodies in the Solar System, yet the mechanisms responsible remain poorly constrained. Here, we present high-precision nickel (Ni) isotope data from a suite of angrite samples to reconstruct the APB's volatile depletion history. Plutonic angrites contain unusually high proportions of metallic iron and exhibit chondritic delta 60/58Ni values (0.202 +/- 0.028%o; per mille mass-dependent 60Ni/58Ni deviation rela...