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作者：Austin, Anne; Baker, Brenda J.; Jovanovic, Tatijana M.; O'connell, James F.
作者单位：University of Missouri System; University of Missouri Saint Louis; Arizona State University; Arizona State University-Tempe; University of London; University College London
摘要：Evidence for tattooing in ancient Nubia is long- standing, although no systematic studies have compared application techniques, motifs, and the demography of tattooed individuals. We surveyed 1,048 Meroitic to medieval (c. 350 BCE-1400 CE) human remains from Semna South (n = 589), Kulubnarti (n = 406), and the Qinifab School site (n = 53). We recorded where skin preservation was sufficient for tattoo observation and used multispectral imaging methods to identify motifs and application techniqu...
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作者：Kaplan, Deanna M.; Palitsky, Roman; Raison, Charles L.
作者单位：Emory University; Emory University; Emory University; University of Wisconsin System; University of Wisconsin Madison
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作者：Wang, Yang; Huang, Zi - Jia; Yu, Nan - Nan; Liang, Jun - Ze; Zeng, Yong - Hui; Zhao, Qian; Zhou, Yi - Ping; Zeng, Yu - Jie; Sun, Zheng - Hua; Zhang, Shuixing; He, Qing-Yu; Zhang, Jing
作者单位：Jinan University; Jinan University; Jinan University; Jinan University
摘要：The activation of the vesicular trafficking system, including endosomal recycling and extracellular vesicle (EV) release, represents an adaptive mechanism in cancer cells to counteract cellular stress or necroptotic death signals, which hampers cancer therapy. However, the underlying mechanisms remain poorly understood. Indeed, our study demonstrate that inhibition of valosin- containing protein (VCPi) induces EV release and necroptosis in colorectal cancer (CRC), but does not achieve a synerg...
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作者：Zamborain-Mason, Jessica; Cinner, Joshua E.; Macneil, M. Aaron; Beger, Maria; Booth, David; Ferse, Sebastian C. A.; Golden, Christopher D.; Graham, Nicholas A. J.; Hoey, Andrew S.; Mouillot, David; Connolly, Sean R.
作者单位：King Abdullah University of Science & Technology; Harvard University; Harvard T.H. Chan School of Public Health; Lancaster University; James Cook University; University of Sydney; Dalhousie University; University of Leeds; University of Queensland; University of Technology Sydney; Leibniz Association; Leibniz Zentrum fur Marine Tropenforschung (ZMT); University of Bremen; Ifremer; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Smithsonian Institution; Smithsonian Tropical Research Institute
摘要：Many coral reefs have fish stocks that are depleted below the level at which sustainable production is maximized. Lower production means that millions of people are losing out on potential food, income, and livelihoods. Rebuilding these stocks to maximize sustainable production can contribute toward ending hunger and malnutrition but requires active and effective fisheries management. Yet, for fish stock recovery plans to be implemented, recovery benefits, targets, and timeframes need to be qu...
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作者：Tian, Hao; Beltran, Jesus; George, Wesley; Lenert-Mondou, Chase; Seder, Norman; Davis, Zoe I.; Swift, Samuel D.; Girke, Thomas; Whitehead, Timothy A.; Wheeldon, Ian; Cutler, Sean R.
作者单位：University of California System; University of California Riverside; University of California System; University of California Riverside; University of California System; University of California Riverside; University of Colorado System; University of Colorado Boulder; University of California System; University of California Riverside; University of California System; University of California Riverside; University of California System; University of California Riverside
摘要：Small-molecule sensing in plants is dominated by chemical-induced dimerization modules. In the abscisic acid (ABA) system, allosteric receptors recruit phosphatase effectors and achieve nM in vivo responses from mu M receptor-ligand interactions. This sensitivity amplification could enable ABA receptors to serve as generic scaffolds for designing small-molecule sensors. To test this, we screened collections of mutant ABA-receptors against 2,726 drugs and other ligands and identified 553 sensor...
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作者：Williams, Sandra G.; Sim, Soyeong; Guiblet, Wilfried M.; George, Jubin; Jones, Jennifer C.; Wolin, Sandra L.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
摘要：Although most studies of the RNAs within extracellular vesicles (EVs) have focused on messenger RNA (mRNA) and microRNAs (miRNAs), recent analyses have revealed that transfer RNAs (tRNAs) and other noncoding RNAs (ncRNAs) are far more abundant. However, the extent to which EV ncRNAs resemble overall cellular RNAs and the benefits to host cells of packaging them into EVs remain unknown. Here, we purified EVs from the culture media of mouse and human cells and characterized their RNA components ...
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作者：Brannon, Charlotte M.; Prakash, Manu
作者单位：Stanford University; Stanford University; Stanford University; Stanford University
摘要：Multicellular organisms utilize epithelial folding to achieve remarkable threedimensional forms. During embryonic development, stereotypical epithelial folds emerge from underlying active cellular and molecular processes including cell shape change and differential cell growth. However, the origin of epithelial folding in early animals and how folding may be harnessed in synthetic systems remain open questions. Here, we identify a modality of behavior-induced epithelial folding and unfolding a...
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作者：Popoli, Alessandro; Mentink, Remco A.; Brombach, Lisa; Karanikou, Nora Papadima-; Buendia-Monreal, Manuel; Fang, Mingming; Joshi, Manas; Yoshida, Saiko; Laurent, Stefan; Huijser, Peter; Tsiantis, Miltos
作者单位：Sapienza University Rome; Consiglio Nazionale delle Ricerche (CNR); Istituto di Biologia e Patologia Molecolari (IBPM-CNR); University of Milan; University of Groningen; University of Bern; BioNTech SE; Max Planck Society
摘要：Cis-regulatory sequences, such as enhancers, play a crucial role in morphological evolution, but how their diversification leads to evolution of novel expression patterns that underpin diversity is still poorly understood. Recent work suggests that the function of enhancers is influenced by their genomic sequence context more than previously thought, further complicating our understanding of their contribution to diversity. To address these issues, we investigated the regulation of the RCO hom...
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作者：Lemoine, Derek
作者单位：University of Arizona; National Bureau of Economic Research
摘要：The climate is already changing. The present study shows that these changes have already affected the U.S. economy. It develops a formal framework that accounts for how climate change has affected each county's economy by altering current and past weather, both locally and elsewhere around the country. The results show that climate change is already reducing annual U.S. income by 0.32% [95% CI: -0.17 to 0.82%] by altering counties' current, local temperatures, with losses concentrated in the G...
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作者：Agrawal, Aakash; Dehaene, Stanislas
