51期

最新文章

• Interprotomer communication and functional asymmetry in H/ACA snoRNPs AI翻译
  作者：Panwar, Hemendra Singh; Vos, Timothy J.; Xie, Xiaoyan; Jang, H. Josh; Lee, Hyoungjoo; Sheldon, Ryan D.; Worden, Evan J.; Kothe, Ute
  作者单位：University of Manitoba; Van Andel Institute; Van Andel Institute
  摘要：H/ACA small nucleolar ribonucleoproteins (H/ACA snoRNPs) facilitate essential cellular processes such as RNA modification, folding, and stability. Here, we present multiple cryo-EM structures of endogenous insect H/ACA snoRNPs containing two protomers assembled on a two-hairpin H/ACA snoRNA. By characterizing key protein-protein and protein-RNA interactions, we reveal the coordination of pseudouridylation activity across the two protomers which explains the predominance of two-hairpin structur...
• Geography of masting creates greater synchrony in seed scarcity than in seed abundance AI翻译
  作者：Szymkowiak, Jakub; Foest, Jessie J.; Dyderski, Marcin K.; Jastrzebowski, Szymon; Barczyk, Maciej K.; Hacket-Pain, Andrew; Bogdziewicz, Michal
  作者单位：Adam Mickiewicz University; Adam Mickiewicz University; Polish Academy of Sciences; Forest Research Institute; University of Liverpool
  摘要：Interannually highly variable and synchronized production of large seed crops by perennial plants, called masting, drives resource pulses and famines with cascading effects on food webs. While the spatial scale of masting synchrony is well documented, it remains unclear how synchrony differs between years of seed abundance and failure, and how such dynamics extend across species and space. These gaps are important to resolve, as they determine the magnitude and spatial extent of masting effect...
• Warming substantially amplifies Antarctic coastal polynyas as key carbon sinks AI翻译
  作者：Zhou, Chengzhen; Liu, Maodian; Rosenheim, Brad E.; Bianchi, Thomas S.; Zhang, Nikki H.; Cai, Xingrui; Zhang, Qianru; Wang, Xuejun
  作者单位：Peking University; Yale University; Peking University; State University System of Florida; University of South Florida; University System Of New Hampshire; University of New Hampshire; State University System of Florida; University of Florida; University of London; University College London; Duke University
  摘要：The Southern Ocean plays an important role in the global carbon cycle by absorbing atmospheric CO2, aiding climate change mitigation. Antarctic coastal polynyas (ACPs) are key CO2 uptake areas, yet whether this CO2 is effectively sequestered as organic carbon (OC) in marine sediments, and the spatiotemporal dynamics and drivers of this process, remains unclear. Here, we reconstruct a high-resolution record of Holocene (similar to 12,000 y BP) to present-day OC accumulation fluxes and sources i...
• Stabilizing calcium nitride for efficient, long- term electrochemical ammonia synthesis AI翻译
  作者：Goyal, Ishita; Isa, Hasiya Najmin; Gande, Vamsi Vikram; Chauhan, Rohit; Singh, Meenesh R.
  作者单位：University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital
  摘要：Electrochemical ammonia synthesis at ambient conditions via calcium-mediated nitrogen fixation holds considerable promise but is impeded by fundamental gaps such as poor gas-liquid interface stability, sluggish hydrogen oxidation reaction (HOR) kinetics, and instability of the critical intermediate calcium nitride. To systematically address these barriers, we i) introduced a high surface-area Ni-based anode specifically selected for enhancing HOR kinetics and minimizing solvent oxidation; ii) ...
• Merkel cell mechanotransduction facilitates adult neurogenesis and cognition in an enriched environment AI翻译
  作者：Luo, Xing; Liu, Qiang; Qin, Dezhe; Wang, Min; Guo, Weixiang
  作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：The tactile system empowers us to act on and interact with the changes of the external environment. In rodents, tactile sensation, a fundamental sense, is largely mediated via the vibrissae and the barrel cortex. However, it remains unclear how tactile perception reshape the brain when exploring a novel environment. Here, we showed that exposure to an enriched environment (EE) failed to enhance adult neurogenesis and cognition in the mice with defective touch perception due to loss of a mechan...
• Band pattern formation of erythrocytes in density gradients is due to competing aggregation and net buoyancy AI翻译
  作者：Maurer, Felix; Romero, Camila; Lerch, Nikolas; John, Thomas; Kaestner, Lars; Wagner, Christian; Darras, Alexis
  作者单位：Saarland University; Universitatsklinikum des Saarlandes; University of Luxembourg; University of Bristol
  摘要：Centrifugation of biological matter in density gradient solutions is a standard method for separating cell types or components. It is also used to separate red blood cells (RBCs) by age, as they lose water and become denser over their lifespan. When the density gradient is prepared with Percoll, discrete bands of RBCs are systematically observed along the gradient, despite the continuous density distribution of RBCs. Early studies suggested that cell aggregation might influence spatial distrib...
• Physical exercise increases binding of POMC to blood extracellular vesicles AI翻译
  作者：Santos, Mark F.; Randa, Jacqueline; Tai, Derek; Vistoli, Giulio; Schahaf, Nofar Avihen; Vittorio, Serena; Fuentes, Geily; Lauro, Rita; Mosallaei, Sheila; Karbanova, Jana; Yokomizo, Alexandra M. K.; Corbeil, Denis; Hightower, Cheryl E.; Lorico, Aurelio
  作者单位：University of Milan; University of Messina; Technische Universitat Dresden; Technische Universitat Dresden; Technische Universitat Dresden
  摘要：Physical exercise affects multiple physiological processes, including those regulated by hormones, such as energy balance, stress responses, and pain perception. The prohormone precursor proopiomelanocortin (POMC) gives rise to f3- endorphin, adrenocorticotropic hormone, f3- lipotropin, and the melanocyte- stimulating hormones (MSH), which act through melanocortin (MC1- 5) and opioid receptors to influence these key physiological responses. Here, we identified a mechanism by which full- length...
• Electroextraction of low-concentration redox-active heavy metals with Eθ < 0 V from acid mine drainage AI翻译
  作者：Huang, Ziyuan; Feng, Chunhua; Wu, Fengchang; Shi, Zhenqing; Wang, Yang; Zhang, Zhuoyu; Huang, Rimei; Duan, Weijian; Tian, Li; Lv, Yijin; Gong, Xinying; Gong, Zhengjun; Dang, Zhi; Li, Fangbai
  作者单位：South China University of Technology; Chinese Research Academy of Environmental Sciences; Southwest Jiaotong University; Guangdong Academy of Sciences; Institute of Eco-environmental & Soil Sciences, Guangdong Academy of Sciences
  摘要：Electrochemical recovery of heavy metals from acid mine drainage (AMD) offers a sustainable solution to global AMD contamination, yet remains challenged by thermodynamic and kinetic barriers in reducing redox-active metals with negative standard reduction potentials (E-theta < 0 V), especially at low concentrations. Here, using Cd as a model system, we demonstrate that the formation of a metastable intermediate, Cd2SO4(OH)(2), plays a crucial role in facilitating the efficient electrochemical ...
• Derepression of transposable elements in the mouse prefrontal cortex disrupts social behavior AI翻译
  作者：Kim, R. Kijoon; Smith, Corinne; Truby, Natalie L.; Strandberg, Shelbey R.; Bell, Jessica L.; Carwile, Nic; Silva, Gabriella M.; Neve, Rachael L.; Aung, Theingi; Cui, Xiaohong; Hamilton, Peter J.
  作者单位：Virginia Commonwealth University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
  摘要：The neurobiological origins of social behaviors are poorly understood. Previous studies have linked the function of a single Kr & uuml;ppel-associated box zinc finger protein (KZFP), ZFP189, in the mouse prefrontal cortex (PFC), with the regulation of transposable elements (TEs), immune genes, and social behaviors. Here, we expand the scope of inquiry to explore the relationship between collective PFC KZFP function and social behaviors by altering the function of the cognate KZFP interacting p...
• The variability of evolvability: Properties of dynamic fitness landscapes determine how phenotypic variability evolves AI翻译
  作者：Petak, Csenge; Frati, Lapo; Vroomans, Renske M. A.; Pespeni, Melissa H.; Cheney, Nick
  作者单位：University of Vermont; University of Vermont; University of Vermont; University of Cambridge; University of Cambridge
  摘要：The magnitude and shape of phenotypic variation depends on properties of the genotype-to-phenotype (GP) map, which itself can evolve over time. The evolution of GP maps is particularly interesting in variable environments, as GP maps can evolve to bias variation in the direction of past selection, increasing the evolvability of the population over time. However, the degree and manner in which environmental variation shapes GP maps and influences evolutionary dynamics may depend on properties o...