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作者：Heine, Julia H.; Drake, Donald R.; Hume, Julian P.; Albert, Sebastien; Ando, Haruko; Baider, Claudia; Bellingham, Peter J.; Case, Samuel B.; Chimera, Charles G.; Florens, F. B. Vincent; Fricke, Evan C.; Gawel, Ann Marie; Gonzalez-Castro, Aaron; Heleno, Ruben; Hervias-Parejo, Sandra; Hruska, Amy; Imada, Clyde T.; de Lima, Ricardo F.; Nogales, Manuel; Rogers, Haldre S.; Rumeu, Beatriz; Strasberg, Dominique; Traveset, Anna; Valido, Alfredo; Watanabe, Kenta; Wotton, Debra; Yoshikawa, Tetsuro; Rahbek, Carsten; Borregaard, Michael K.
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作者：Pakhira, Santanu; Lee, Yongbin; Kundu, Asish K.; Islam, Farhan; Ning, Zhenhua; Smetana, Volodymyr; Mudring, Anja-Verena; Heitmann, Thomas; Vescovo, Elio; Ke, Liqin; Vaknin, David; Johnston, David C.
作者单位：Iowa State University; United States Department of Energy (DOE); Ames National Laboratory; National Institute of Technology (NIT System); Maulana Azad National Institute of Technology Bhopal; United States Department of Energy (DOE); Brookhaven National Laboratory; United States Department of Energy (DOE); Brookhaven National Laboratory; Iowa State University; University of Missouri System; University of Missouri Columbia
摘要：The interplay between magnetism and flat-band (FB) instability is a central theme in quantum materials research. A striking example is the emergence of magnetic order in a nominally nonmagnetic compound when a flat band is tuned near the Fermi energy (EF). In this study, we investigate this phenomenon in the Pauli EF. Remarkably, a minute substitution of the nonmagnetic element Pd onto the Co site (similar to 2%) induces antiferromagnetic order with a transition temperature as high as TN = 25 ...
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作者：Wang, Chenglong; Tang, Haoyu; Yang, Xiyuan; Xie, Yueqi; Suh, Jina; Sitaram, Sunayana; Huang, Junming; Xie, Yu; Zhao, Pengjun; Gong, Zhaoya; Xie, Xing; Wu, Fangzhao
作者单位：Peking University Shenzhen Graduate School (PKU Shenzhen); Peking University; Peking University; Ministry of Natural Resources of the People's Republic of China; Peking University Shenzhen Graduate School (PKU Shenzhen); Renmin University of China; University of Illinois System; University of Illinois Urbana-Champaign; Hong Kong University of Science & Technology; Princeton University; Microsoft; Peking University; Microsoft Research Asia; Microsoft; Microsoft China
摘要：As large language models (LLMs) gradually demonstrate their potential to boost productivity and become integral tools for problem-solving in daily life worldwide, understanding the linguistic inequalities they introduce is becoming increasingly important. Prior research has primarily focused on static analyses of disparities in existing knowledge and capabilities of LLMs across languages. However, LLMs are continuously evolving, acquiring new knowledge to provide current, relevant responses an...
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作者：Zhang, Linjing; Meng, Kaiwen; Xiang, Ye
作者单位：Tsinghua University; Shanxi Medical University
摘要：Entry of Rift Valley fever virus (RVFV) into host cells is mediated by the viral glycoproteins Gn and Gc. Structural details and assembly mechanism of Gn and Gc on the surface of RVFV remain unclear. Here, we stabilized the GnGc with the neutralizing monoclonal antibody RVFV- 140 and determined a near- atomic resolution structure of the GnGc hexamer in complex with the fragment antigen binding (Fab) domain of RVFV- 140 (Fab140). Our structure showed that RVFV- 140 recognizes a ternary epitope ...
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作者：D'Amour, Alexander
作者单位：Alphabet Inc.; DeepMind
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作者：Jarzynski, Christopher; Deffner, Sebastian; Rahav, Saar
作者单位：University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland Baltimore County; University System of Maryland; University of Maryland Baltimore County; Technion Israel Institute of Technology
摘要：Classical fluctuation theorems for work have been obtained theoretically, and verified experimentally, within a nonautonomous framework in which work is performed on a system of interest, S, by the external manipulation of a work parameter, such as a piston's position. Here, we obtain fluctuation theorems within an autonomous framework in which S exchanges energy with a reversible work source, R. The two subsystems, R and S, interact with one another as they evolve under Hamiltonian or stochas...
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作者：Li, Yang; Xing, Zhongliang; Hu, Wen; Wu, Kai; Xu, H. Eric; Zhao, Li - Hua
作者单位：Fudan University; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Shanghai Jiao Tong University
摘要：The somatostatin receptor subtype 5 (SSTR5) is a critical pharmacological target involved in neuroendocrine signaling, metabolic regulation, and tumorigenesis. Despite its therapeutic potential, the structural mechanisms underlying SSTR5 inhibition by nonpeptide antagonists remain largely unresolved. In this study, we present high-resolution cryoelectron microscopy structures of human SSTR5 in complex with two selective small-molecule antagonists, antagonist 1 and S5A1, revealing the receptor'...
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作者：Park, Hyunji; Choi, Minjun; Zhang, Yu; Cheung, Helen Oi- Lam; Makino, Shigeru; Yoshikawa, Yoshiaki; Qi, Haoran; Liu, Zheng; Lan, Guocheng; Fu, Guoling; Wang, Qian; Guo, Shiny Shengzhen; Liu, Pengtao; Liu, Zhen; Ti, Shih - Chieh; Wang, Won - Jing; Li, Xiang David; Ni, Tao; Hui, Chi - Chung; He, Mu
作者单位：University of Hong Kong; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Hong Kong; Hong Kong University of Science & Technology; Max Planck Society; National Yang Ming Chiao Tung University; University of Hong Kong; The University of Hong Kong Shenzhen Institute of Research & Innovation; Shizuoka University
摘要：Motile cilia are eukaryotic organelles with essential chemo-and mechanosensing functions across evolution, from single cell organisms to humans. Motile cilia of the mammalian nervous, respiratory, and reproductive systems are characterized by unique motility proteins to generate fluid flow essential for transporting metabolites and removing mucus. The molecular mechanism underlying motile cilia assembly remains unknown. Here, we use high-resolution imaging, proteomics, in situ cryotomography, ...
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作者：Russo, John
作者单位：Sapienza University Rome
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作者：Zhang, Xin-Ya; Tang, Chao
作者单位：Westlake University; Westlake University; Westlake University
摘要：Like human decision-making under real-world constraints, artificial neural networks may balance free exploration in parameter space with task-relevant adaptation. In this study, we identify consistent signatures of criticality during neural network training and provide theoretical evidence that such scaling behavior arises naturally from information-driven self-organization: a dynamic balance between the maximum entropy principle that promotes unbiased exploration and mutual information constr...
