51期

最新文章

• Designing strongly coupled polaritonic structures via statistical machine learning AI翻译
  作者：Yang, Yang; Guo, Xiangdong; Zhang, Shu; Dai, Qing; Deng, Ke; Liu, Jun S.
  作者单位：Nankai University; Shanghai Jiao Tong University; Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Tsinghua University
  摘要：Strong coupling photonics, in which coupling strengths significantly exceed decay factors, holds great promise for applications in energy conversion and information processing. However, the effective and scalable design of strongly coupled polaritonic structures requires precise determination of the transition boundaries between strong and weak coupling regions. Traditional trial- and- error methods and classical machine learning (ML) algorithms struggle to achieve this due to the inherent dif...
• A further modification of the elastic field of an edge dislocation AI翻译
  作者：Hirth, John P.; Wang, Jian
  作者单位：University System of Ohio; Ohio State University; University of Nebraska System; University of Nebraska Lincoln
  摘要：A previous modification removed a nonphysical divergence of the elastic displacement field of an edge dislocation. The traditional elastic equations are correct to linear elastic order. However, there is a disregistry of the displacement field at +/- infinity that significantly influences the elastic displacements and is missed in the linear elastic description. The earlier revision included volumetric nonlinear elasticity through the use of embedded coordinates and included the disregistry as...
• CHARGE-MAP: An integrated framework to study the multicriteria EV charging infrastructure expansion problem AI翻译
  作者：Islam, Kazi Ashik; Kishore, Aparna; Meyur, Rounak; Thorve, Swapna; Chen, Da Qi; Poor, H. Vincent; Marathe, Madhav V.
  作者单位：University of Virginia; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Princeton University
  摘要：The widespread adoption of electric vehicles (EVs) in recent years has necessitated the development of effective charging infrastructures. However, charging infrastructure expansion is a multifaceted problem that requires careful consideration of the existing infrastructure, spatiotemporal distribution of charging demands, power-grid capacity, and budget constraints. To approach this complex problem, we present CHARGE-MAP, data-driven simulation-optimization framework, focused on ensuring mean...
• Domestication is adaptive evolution in response to human use AI翻译
  作者：Kohl, Patrick L.
  作者单位：University Hohenheim; University Hohenheim
• Single- nucleus and spatial transcriptomics reveal the cell populations of intercalary meristems in bamboo AI翻译
  作者：Qin, Ning; Liu, Xin; Li, Shanying; Sun, Lei; Chen, Chuan; Lou, Wenrui; Wang, Xianke; Bao, Pengfei; Cao, Bingchen; Zhang, Huan; Gan, Junwei; Hou, Yinguang; Fan, Zeyu; Liu, Jianlin; Wang, Yu; Yang, Huanming; Zhao, Hansheng
  作者单位：International Centre for Bamboo & Rattan; Nanjing Agricultural University; International Centre for Bamboo & Rattan
  摘要：Intercalary meristems (IcMs), specialized developmental zones that drive rapid stem elongation in monocots, exhibit distinct spatiotemporal dynamics; however, their genetic basis remains poorly understood due to their transient activity and cellular heterogeneity. Moso bamboo (Phyllostachys edulis)-with its exceptional daily growth rates of up to 114.5 cm, prolonged IcM activity spanning 45 to 60 d, and large, accessible culm structure-provides an ideal system for building a comprehensive IcM ...
• Dual-targeted ping-pong CAR T cells: Leveraging peripheral to solid tumor AI翻译
  作者：Finck, Amanda, V; Wang, Ziming; Gonzales, Donna; Wellhausen, Nils; Castelli, Sofia; Banerjee, Esha; Aznar, M. Angela; Young, Regina M.; June, Carl H.
  作者单位：University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; University of Pennsylvania
  摘要：Clinical responses to CD19-directed CAR T cell therapy in B cell malignancies are strongly associated with robust CAR T cell expansion in the peripheral blood. In contrast, CAR T cells targeting solid tumors do not encounter cognate antigen in the periphery, resulting in limited expansion and subtherapeutic peak concentrations. To overcome this, we engineered dual-targeted and dual-costimulated CAR T cells (CD19/28 zeta- M5BB zeta) that recognize CD19+ B cells, thereby promoting peripheral exp...
• Convergent mutation trajectories convert functional self- tolerance in IGHV4-34 B cells to genetic tolerance encoded in the antibody AI翻译
  作者：Jara, Christopher J.; Zachariah, Sherin; Jackson, Katherine J. L.; Peters, Timothy J.; Masle-Farquhar, Etienne; Burnett, Deborah L.; Lam, Eric; Faulks, Megan; Russell, Amanda; Miosge, Lisa; Smith, Stewart; Tscharke, David C.; Brink, Robert; Goodnow, Christopher C.; Reed, Joanne H.
  作者单位：Garvan Institute of Medical Research; University of Sydney; Westmead Institute for Medical Research
  摘要：Preventing autoantibody secretion by rendering self-reactive B cells functionally silent through clonal anergy has long posed the question of why fill the circulating B cell repertoire with cells that cannot secrete antibody? Here we address this question from the perspective of B cells that comprise 5 to 10% of the human circulating repertoire, expressing self-reactive surface immunoglobulins employing the IGHV4-34 heavy chain variable element. Using gene targeting to construct mice expressin...
• An abundant membrane protein in the NCAM superfamily is required for epithelial organization in sea anemone embryos AI翻译
  作者：Postnikova, Anna; Tello, Julissa G.; Alvarez, Maristhela; Lee, Grace Y.; Ali, Ilhan; Field, Christine M.; Mitchison, Timothy J.; Ragkousi, Katerina
  作者单位：Amherst College; Harvard University; Harvard Medical School
  摘要：Assembly of cells into epithelial layers marks the early steps of tissue organization and embryonic development in most animals. Although several conserved proteins are known to be essential for epithelialization in bilaterians, it is unclear whether these are sufficient to drive epithelial organization in all metazoans. Using proteomics and knockdown approaches in embryos of the early-branching sea anemone Nematostella vectensis, we identified the Neural Cell Adhesion Molecule (NCAM) NCAM2 to...
• Dynamic functional connectivity following cochlear implantation: Predicting speech outcomes and exploring brain network dynamics AI翻译
  作者：Esmaelpoor, Jamal; Peng, Tommy; Jelfs, Beth; Mao, Darren; Shader, Maureen J.; McKay, Colette M.
  作者单位：University of Melbourne; Bionics Institute; University of Birmingham; Purdue University System; Purdue University
  摘要：Cochlear implants (CIs) have transformed hearing restoration for individuals with severe or profound hearing loss, yet outcomes vary widely and remain difficult to predict. This study introduces an approach by examining the temporal dynamics of brain functional networks postimplantation to identify predictors of outcomes and explore brain plasticity. Twenty- nine CI candidates and 23 normal- hearing individuals participated. Functional near- infrared spectroscopy measured brain activity during...
• Anyon delocalization transitions out of a disordered fractional quantum anomalous Hall insulator AI翻译
  作者：Shi, Zhengyan Darius; Senthil, T.
  作者单位：Massachusetts Institute of Technology (MIT)
  摘要：Motivated by the experimental discovery of the fractional quantum anomalous Hall effect, we develop a theory of doping-induced transitions out of the v = 2/3 lattice Jain state in the presence of quenched disorder. We show that disorder strongly affects the evolution into the conducting phases described in our previous work. The delocalization of charge 2/3 anyons leads to a chiral superconductor through a direct second-order transition for a smooth random potential with long-wavelength modula...