-
作者:Wen, Long; Chen, Gang; Wang, Shuguang; Nie, Ji; Zhao, Kun
作者单位:Nanjing University; Peking University; Nanjing University; Peking University
摘要:Persistent knowledge gaps in precipitation microphysics, particularly the nonlinear coupling between microphysical process hierarchies and raindrop size distribution (DSD) variability, keep introducing systemic uncertainties into precipitation retrievals and model simulations. Here, we address this challenge through a unified framework that integrates observations from China's national-scale disdrometer network (1,031 sites) and 10-year global dual-frequency precipitation satellite dataset. Fi...
-
作者:Melton, Douglas A.; De Robertis, Edward M.
作者单位:Harvard University; Vertex Pharmaceuticals; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA
摘要:The death of Sir John Bertrand Gurdon in October 2025 marks the passing of one of the most influential biologists of the modern era. A developmental biologist, Sir Gurdon's best-known experiments were performed with frog eggs and nuclear transfer, leading to discoveries that transformed our understanding of how genes control animal development and established the principles that underpin animal cloning, nuclear reprogramming, and regenerative medicine. These classical experiments paved the way...
-
作者:Rafay, Ramis; Jones, Eric W.; Sivak, David A.; Fowler, S. Jane
作者单位:Simon Fraser University; University of Colorado System; University of Colorado at Colorado Springs; University of Colorado System; University of Colorado at Colorado Springs; Simon Fraser University
摘要:Biological communities are connected through dispersal, which regulates diversity across local and regional scales. However, dispersal is difficult to measure directly, limiting what is known about dispersal's impact on species composition in complex communities. One method to measure dispersal employs the Neutral Community Model (NCM) to quantify how a local community is influenced by the immigration of individuals from a larger source community.Conveniently, the immigration rate NTm of the N...
-
作者:Vilbig, Karyn; England, Paula
作者单位:New York University; New York University; New York University Abu Dhabi
摘要:Recent discussion of voting in US elections claims a strong movement of White working-class voters away from voting for Democrats, with much discussion focusing only on elections between 2012 and the present. We examine longer-term trends from 1980 to 2020 in how more and less privileged White voters-measured by household income, education, and occupational class-moved toward or away from voting Democratic. We also explore how these movements changed the shape of the relationships between thes...
-
作者:Hao, Chunhui; Konno, Naoki; Ito, Makoto; Belcher, Laurence J.; Iwasaki, Wataru; West, Stuart A.
作者单位:University of Oxford; Nanjing University; East China Normal University; University of Tokyo; University of Tokyo
摘要:Bacteria exhibit varying niche breadths, with generalists thriving in diverse environments and specialists confined to specific habitats. Although genes for cooperative traits have been suggested to influence niche breadth evolution, their precise role remains unclear. We used a combination of phylogeny-based comparative methods to test causal hypotheses about the directionality of the relationship between genes for cooperation and bacterial niche breadth evolution across 25,785 species. Our r...
-
作者:Aggarwal, Ishu; Webb, Jacqueline F.; Onck, Patrick R.; Kottapalli, Ajay Giri Prakash
作者单位:University of Groningen; University of Groningen; University of Rhode Island; Harvard University
摘要:The mechanosensory lateral line system, found in all fishes, detects water movement and pressure fields and mediates crucial behaviors in aquatic environments. Neuromast sensory organs, the functional units of the system, exhibit diversity in shape and size among species, but structure-function relationships that could explain this impressive diversity have not been explored. Here, we employ a fluid-structure interaction-based computational model that uses the shape and size of the base of the...
-
作者:Gao, Jiali; Chen, Xiaohua
作者单位:Peking University Shenzhen Graduate School (PKU Shenzhen); Peking University; Shenzhen Bay Laboratory; University of Minnesota System; University of Minnesota Twin Cities; Chongqing University
-
作者:Jia, Mengqi; Peng, Bin; Guan, Kaiyu; Lawrence, David M.; Delucia, Evan H.; Knapp, Alan K.; Barron-Gafford, Greg A.; Khanna, Madhu; Lombardozzi, Danica L.; Sturchio, Matthew A.; Kannenberg, Steven A.; Zhao, Lei; McCall, James; Tang, Jinyun; Bernacchi, Carl J.; Mwebaze, Paul; Majeed, Fahd; Lee, Dokyoun; Time, Alson
作者单位:University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins; University of Arizona; University of Illinois System; University of Illinois Urbana-Champaign; Colorado State University System; Colorado State University Fort Collins; West Virginia University; University of Illinois System; University of Illinois Urbana-Champaign; United States Department of Energy (DOE); National Renewable Energy Laboratory - USA; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Agriculture (USDA)
摘要:Increasing global demands for food and energy necessitate innovative land-use solutions. Agrivoltaics, colocating solar photovoltaics with agriculture, shows promise, but its widespread adoption faces complex biophysical and economic trade-offs in a changing climate. Here, we develop an integrated biophysical-economic modeling framework to quantify how agrivoltaics affect biophysical and economic impacts across the Midwestern United States under both current and project climate conditions. We ...
-
作者:Ramsey, Erin L.; Dobersch, Stephanie; Freie, Brian; Hong, Nan Hyung; Wu, Xiaoying; Kugel, Sita; Eisenman, Robert N.; Carroll, Patrick A.
作者单位:Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center
摘要:MYC amplification contributes to poor survival and outcome in pancreatic ductal adenocarcinoma (PDAC). Here we show that in PDAC cell lines with amplified MYC, MondoA is required for viability, facilitating proliferation while suppressing apoptosis in vitro and in vivo. Transcriptional and genomic profiling demonstrates that loss of MondoA leads to altered expression of direct MondoA targets as well as MYC target genes and is accompanied by shifts in genomic occupancy of MYC, MNT, and the Mond...
-
作者:Sutherland, William J.; Burgess, Neil D.; Edwards, Scott, V; Jones, Julia P. G.; Soltis, Pamela S.; Tilman, David; Allen, Julie M.; Andrianandrasana, Herizo T.; Armour, Cathrine J.; August, Tom; Bawa, Kamaljit S.; Bailey, Sallie; Birch, Tanya; Boersch-Supan, Philipp H.; Cavender-Bares, Jeannine; Blaxter, Mark; Chaplin-Kramer, Rebecca; Daru, Barnabas H.; De Palma, Adriana; Eisenberg, Cristina; Elphick, Chris S.; Freckleton, Robert P.; Frick, Winifred F.; Gonzalez, Andrew; Goetz, Scott J.; Greenspoon, Lior; Grozinger, Christina M.; Hankins, Don L.; Hazell, Jonny; Isaac, Nick J. B.; Lambertini, Marco; Lewin, Harris A.; Mac Aodha, Oisin; Madhavapeddy, Anil; Milner-Gulland, Ej; Milo, Ron; O'dwyer, James; Purvis, Andy; Salafsky, Nick; Tallis, Heather; Tanshi, Iroro; Vijay, Varsha; Wikelski, Martin; Williams, David R.; Woodard, S. Hollis; Robinson, Gene E.
作者单位:University of Cambridge; United Nations Environment Programme; University of Copenhagen; Harvard University; Bangor University; Utrecht University; State University System of Florida; University of Florida; University of Minnesota System; University of Minnesota Twin Cities; Virginia Polytechnic Institute & State University; University of Helsinki; UK Centre for Ecology & Hydrology (UKCEH); University of Massachusetts System; University of Massachusetts Boston; British Trust for Ornithology; Wellcome Trust Sanger Institute; World Wildlife Fund; Stanford University; Natural History Museum London; University of Connecticut; University of Connecticut; University of Sheffield; University of California System; University of California Santa Cruz; McGill University; Northern Arizona University; Weizmann Institute of Science; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; University of Edinburgh; University of Cambridge; University of Oxford; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of California System; University of California Santa Cruz; University of Washington; University of Washington Seattle; Max Planck Society; University of Konstanz; University of Leeds; University of California System; University of California Riverside; University of Illinois System; University of Illinois Urbana-Champaign
摘要:Biodiversity is declining in many parts of the world. Biological diversity measurement and monitoring are fundamental to the assessment of the causes and consequences of environmental changes, identification of key areas for the protection of biodiversity or ecosystem services, determining the effectiveness of actions, and the creation of decision-support tools critical to maintaining a sustainable planet. Biodiversity measurement is rapidly changing due to advances in citizen science, image r...