31期

最新文章

• Rapid microbial production of long-lived dissolved organic carbon in the global ocean AI翻译
  作者：Cai, Ruanhong; Lechtenfeld, Oliver J.; Tanentzap, Andrew J.; Sachs, Julian P.; Kao, Shuh-Ji; Osterholz, Helena; Yan, Zhenwei; Zhao, Chen; Yi, Yuanbi; Li, Penghui; Zhang, Chuanlun; Jiao, Nianzhi; Koch, Boris P.; Herndl, Gerhard J.; He, Ding
  作者单位：Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; Helmholtz Association; Trent University; Carl von Ossietzky Universitat Oldenburg; University of Washington; University of Washington Seattle; Hainan University; Hainan University; Leibniz Institut fur Ostseeforschung Warnemunde; Sun Yat Sen University; Sun Yat Sen University; Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Zhuhai); Xiamen University; Xiamen University; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; University of Vienna; Utrecht University; Royal Netherlands Institute for Sea Research (NIOZ); City University of Hong Kong; Hong Kong University of Science & Technology; Hong Kong University of Science & Technology
  摘要：Marine microbes have long been regarded as central to replenishing the ocean's reservoir of recalcitrant dissolved organic matter (RDOM). However, molecular-level evidence for their role remains inconclusive because RDOM persists for years to millennia, far exceeding timescales accessible to laboratory experiments, and because conventional analytical approaches lack the resolution to discern structural isomers of RDOM that confer functionally important differences in persistence. Using polarit...
• Dietary DNA in municipal wastewater reveals signatures of wealth, immigration, and coastal proximity AI翻译
  作者：Dong, Mengyi; Clerkin, Thomas Joseph; Jiang, Sharon; Ives, Nolan; Osborne, Olivia W.; Kirtley, Michelle; Bauer, Anna E.; Anderson, Katherine Y.; Smith, Martin D.; Noble, Rachel T.; David, Lawrence A.
  作者单位：Duke University; University of North Carolina; University of North Carolina Chapel Hill; Duke University; Duke University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Duke University
  摘要：Public health nutrition lacks scalable, objective tools for real-time dietary surveillance. We developed FoodSeq-FLOW (Food Landscape Observation in Wastewater), a genomic platform that sequences chloroplast trnL and mitochondrial 12SV5 DNA in municipal wastewater. Across 183 samples from 21 North Carolina wastewater treatment plants serving 2.1 million people, we detected 184 plant and 116 animal food taxa at a cost of < US $0.01 per person. Wastewater-derived dietary profiles correlated with...
• Source limitation drives slow compositional recovery in tropical secondary forests AI翻译
  作者：Genes, Luisa; Wendt, Amanda; Finegan, Bryan; Barber, Cristina; Delgado, Diego; Pelaez, Marta; Huanca Nunez, Nohemi; Kobe, Richard K.; Dirzo, Rodolfo; Chazdon, Robin L.
  作者单位：Stanford University; Michigan State University; Universidad Politecnica de Madrid; Yale University; Stanford University; Stanford University; University of the Sunshine Coast; University of Connecticut
  摘要：Tropical forests can recover diversity, structure, and function rapidly after disturbance. However, plant compositional recovery remains incomplete even after many decades, and the reasons for this lag are poorly understood. We investigated the roles of source, dispersal, and establishment limitation in affecting compositional recovery in Costa Rican forests using long-term data on species composition of trees, seeds, seedlings, and saplings, along with measurements of herbivory and leaf patho...
• Insights into hominin body size, locomotion, and behavior from Early Pleistocene trackways in northern Kenya AI翻译
  作者：Hatala, Kevin G.; Roach, Neil T.; Harris, John W. K.; Kiura, Purity; Ndiema, Emmanuel K.; Sila, Ben; Kipkebut, David; Waweru, Joyce; Kisale, Philiphine; Longaye, Apolo Alkoro; Sale, Hilary; Behrensmeyer, Anna K.
  作者单位：Chatham University; Max Planck Society; Harvard University; Rutgers University System; Rutgers University New Brunswick; George Washington University; Smithsonian Institution; Smithsonian National Museum of Natural History; Smithsonian Institution; Smithsonian National Museum of Natural History
  摘要：The Early Pleistocene fossils of the Koobi Fora Formation, northern Kenya, record two well-documented hominin genera, Homo and Paranthropus, preserved in the same deposits. Evidence for their ecological sympatry consists of co-occurring footprints of diverse morphologies, suggesting that Homo erectus and Paranthropus boisei were present in the same lake margin habitats over hundreds of thousands of years. Here, we report on a similar to 1.43 Ma fossil footprint assemblage that sheds light on E...
• Folic acid prevention of neural tube defects requires retinoic acid produced by ALDH1L1 AI翻译
  作者：Edri, Tamir; Abbou-Levy, Tali; Cohen, Dor; Inacio, Jose M.; Shabtai, Yehuda; Pillemer, Graciela; Belo, Jose Antonio; Fainsod, Abraham
  作者单位：Hebrew University of Jerusalem; Universidade Nova de Lisboa
  摘要：Folic acid (FA) supplementation during pregnancy is the commonly accepted treatment to prevent neural tube defects. The mechanism by which FA prevents neural tube defects (NTDs) remains unclear. FA also prevents other developmental malformations, including alcohol-induced malformations in Fetal Alcohol Syndrome models. We show that FA acts through a metabolic link to retinoic acid (RA) signaling. Using a pax3-knockdown Xenopus model of FA-rescuable NTDs, we show that RA or its precursors equal...
• Insufficiency of cohesin regulatory protein PDS5B triggers meiotic failure and aneuploidy in oocytes during advanced maternal aging AI翻译
  作者：Zhang, Yu; Bai, Jie; Li, Na; Xiong, Bo
  作者单位：Zhejiang University; Nanjing Agricultural University
  摘要：Oocytes rely on a cohort of proteins whose sustained expression ensures normal meiotic progression and reproductive competence throughout an animal's reproductive life. Age-related declines in these proteins are a major cause of reduced oocyte quality and female fertility during reproductive aging. Here, we report that the cohesin regulatory protein PDS5B, a dynamically maintained factor in oocytes, declines with age and plays a noncanonical role in the spindle pole formation independent of it...
• High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies AI翻译
  作者：Gervais, Adrian; Marchal, Astrid; Maillard, Alexis; Le Voyer, Tom; Rosain, Jeremie; Philippot, Quentin; Bizien, Lucy; Peel, Jessica; Cederholm, Axel; Migaud, Melanie; Pons, Sylvie; Saker, Kahina; Laforet, Pascal; Aubart, Melodie; Gitiaux, Cyril; Biggs, Catherine M.; Lopez, Rafael Leon; Souvannanorath, Sarah; Tard, Celine; Pakleza, Aleksandra Nadaj; Grapperon, Aude-Marie; Heming, Nicholas; Annane, Djillali; Verschueren, Annie; Attarian, Shahram; Bigaut, Kevin; Hankiewicz, Karolina; Kouton, Ludivine; Villar-Quiles, Rocio-Nur; Cauquil, Cecile; Fleury, Marie-Celine; Rocher, Emilie; Nicolas, Guillaume; de Paula Estephan, Eduardo; da Penha Ananias Morita, Maria; Zanoteli, Edmar; Saied, Zakaria; Rachdi, Amine; Rim, Amouri; Belal, Samir; Ben Sassi, Samia; Hubers, Annemarie; Faure, Emmanuel; Desguerre, Isabelle; Basse, Clemence; Girard, Nicolas; Beziat, Vivien; Pan-Hammarstrom, Qiang; Hammarstrom, Lennart; Bodansky, Aaron; Parent, Audrey V.; Anderson, Mark S.; DeRisi, Joseph L.; Demeret, Sophie; Truffault, Frederique; Fort, Romain; Ader, Florence; Wallet, Florent; Trouillet-Assant, Sophie; Abel, Laurent; Molina, Thierry; Alyanakian, Marie-Alexandra; Le Panse, Rozen; Sole, Guilhem; Cobat, Aurelie; Landegren, Nils; Casanova, Jean-Laurent; Puel, Anne; Bastard, Paul; Jouanguy, Emmanuelle
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Necker-Enfants Malades - APHP; Rockefeller University; Uppsala University; CHU Lyon; Ecole Normale Superieure de Lyon (ENS de LYON); Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); CNRS - National Institute for Biology (INSB); Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Raymond-Poincare - APHP; Universite Paris Saclay; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; University of British Columbia; BC Children's Hospital; Hospital Universitario Reina Sofia - Cordoba; Assistance Publique Hopitaux Paris (APHP); Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire Henri-Mondor - APHP; Universite de Lille; Institut National de la Sante et de la Recherche Medicale (Inserm); CHU Lille; CHU Strasbourg; Aix-Marseille Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital Universitaire Pitie-Salpetriere - APHP; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Bicetre - APHP; Universidade de Sao Paulo; Universite de Tunis-El-Manar; Institut National de Neurologie; Faculte de Medecine de Tunis (FMT); Universite de Tunis-El-Manar; Institut National de Neurologie; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf Hospital; Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital Universitaire Charles-Foix - APHP; Hopital Universitaire Pitie-Salpetriere - APHP; UNICANCER; Universite PSL; Institut Curie; Universite Paris Saclay; Karolinska Institutet; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI); Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite; CHU Lyon; CHU Lyon; CHU Lyon; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; Universite de Bordeaux; CHU Bordeaux; Universite de Bordeaux; Howard Hughes Medical Institute; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Necker-Enfants Malades - APHP
  摘要：Patients with myasthenia gravis (MG) may produce autoantibodies neutralizing type I interferons (AAN-I-IFN), which underlie severe viral diseases, including critical COVID-19 pneumonia, in patients without MG. We studied an international cohort of 85 unvaccinated SARS-CoV-2-infected MG patients not given antiviral treatment. Hypoxemic pneumonia occurred in 48 of these patients, including 22 (45.8%) with AAN-I-IFN, which neutralized both IFN-alpha 2 and IFN-omega in 14 (29.2%) patients. Six (16...
• Abrupt transition to irreversible damage in the overdrafted Sacramento Valley aquifer system AI翻译
  作者：Larochelle, Stacy; Chanard, Kristel; Dalaison, Manon; Fortin, Jerome; Jolivet, Romain; Longuevergne, Laurent; Fleitout, Luce; Argus, Donald F.; Gauer, Louis-Marie; Avouac, Jean-Philippe
  作者单位：University of California System; University of California Los Angeles; California Institute of Technology; Columbia University; Universite Paris Cite; Universite Gustave-Eiffel; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure (ENS); Universite de Rennes; Centre National de la Recherche Scientifique (CNRS); California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL)
  摘要：Groundwater extraction decreases water pressure in aquifer systems, causing reversible or irreversible deformation of the water-bearing layers that manifests as recoverable or permanent displacements of the land surface, respectively. Detecting and forecasting when and where an aquifer system transitions from a reversible, poroelastic regime, to an irreversible, inelastic regime remains a crucial challenge given the complex, heterogeneous nature of aquifer systems. Here we leverage high-resolu...
• Distinct repair processes produce APOBEC-induced deletions, tandem substitutions, and complex mutations in yeast and human cells AI翻译
  作者：Puzon, Alexandra; Raval, Atri; Cordero, Cameron; Schiefen, Daniel; Mieczkowski, Piotr A.; Roberts, Steven A.; Mertz, Tony M.
  作者单位：Washington State University; Washington State University; University of Vermont; University of North Carolina; University of North Carolina Chapel Hill
  摘要：APOBEC3A (A3A) and APOBEC3B (A3B) induce single base substitution signatures SBS2 and SBS13, which are composed of C>T and C>G mutations, respectively, at TCW sequences in >50% of sequenced tumors. However, few driver mutations have been attributed to APOBEC-induced SBS mutations. Although SBS2 and SBS13 have been associated with additional mutation types, the contribution of APOBECs to non-SBS mutations and the mechanisms that generate noncanonical APOBEC-induced mutations are uncharacterized...
• Anterior and posterior retrosplenial cortex employ distinct strategies for egocentric-allocentric transformation in spatial coding AI翻译
  作者：Yang, Youran; Zhang, Xiang; Yuan, Xin; Cai, Haiqian; Cao, Qichen; Miao, Chenglin
  作者单位：Peking University; Peking University; Peking University; Peking University; Chinese Institute for Brain Research, Beijing; Peking University
  摘要：The transformation from egocentric to allocentric spatial coordinates is a critical process in neural spatial computation. The retrosplenial cortex (RSC) is hypothesized to serve as a central hub for this conversion, bridging egocentric perceptual inputs with allocentric representations in hippocampal and parahippocampal circuits. However, the regional and projection-specific organization of this function within the RSC remains poorly defined. In this study, we employed two-photon calcium imag...