-
作者：Murugan, Arvind
作者单位：University of Chicago
-
作者：Nichols, James D.
作者单位：State University System of Florida; University of Florida
-
作者：O'Boyle, Rachel; Shores, Tyler; van der Linden, Sander
作者单位：University of Cambridge; University of Cambridge
摘要：Individuals encounter climate doom, extreme portrayals of climate change, on social media. While climate doom may be intended to motivate action, it may also be perceived as manipulative or elicit hopelessness. Yet, no research has examined whether psychological inoculation helps to improve recognition of climate doom or influences engagement with it on social media. In this preregistered study (n = 521), we tested whether inoculation improves discernment of climate doom and influences engagem...
-
作者：Peterson, Christian E.; Berrey, C. Adam; Drennan, Robert D.
作者单位：University of Hawaii System; University of Hawaii Manoa; California State University System; California State University Sacramento; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：The amount of variation observed among early complex societies has challenged efforts to understand their social dynamics. We advocate for a comparative approach that directly investigates the forces producing this variation. By holistically ranking 63 trajectories of societal change along five axes of differentiation, we characterize their development from a multidimensional perspective. Our analysis reveals that the majority of these trajectories align with one of six recurrent pathways thro...
-
作者：Song, Xinyuan; Deng, Chuang
作者单位：University of Manitoba; Northwestern University
摘要：Interfaces are ubiquitous in materials and play a central role in microstructural evolution and material properties. Although interface migration has been studied for more than a century and remains an active field, several foundational assumptions of interface kinetics remain largely untested. In particular, interfaces are commonly treated as massless objects governed by overdamped dynamics. In this study, we show that grain boundaries exhibit measurable inertial behavior under high-frequency...
-
作者：Kumar, Naveen; Deka, Alvina; Basu, Swapnava; Mishra, Ashish Kumar; Sahu, Deepakshi; Basak, Soumen
作者单位：Department of Biotechnology (DBT) India; National Institute of Immunology (NII); University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester
摘要：While preserving tolerance toward commensals, dendritic cells (DCs) also orchestrate response against pathogens. The noncanonical RelB NF-kappa B pathway in DCs curbs tolerogenic Tregs in the intestine. Whether RelB-dependent DC regulations also impact intestinal immunity remains less clear. Here, we show that genetic ablation of RelB in DCs compromises IL-23-dependent immune response in the intestine, imparting vulnerability in Relb Delta CD11c mice to infection with Citrobacter rodentium, an...
-
作者：Lavender, Hayley; Oliver, Vincent; Lucy, Daniel; Barendt, Timothy A.; Jerse, Ann E.; Tang, Christoph M.
作者单位：University of Oxford; University of Liverpool; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc; University of Oxford; University of Birmingham
摘要：Neisseria gonorrhoeae is the causative agent of gonorrhea, a sexually transmitted infection which is rising in incidence, with increasing drug-resistant strains posing a significant public health threat. To address the urgent need for novel therapies, we developed an antibody-drug conjugate (ADC) that targets this important human pathogen. We utilized Tridecaptin A1, a potent antimicrobial peptide (AMP) against Gram-negative bacteria that exhibits significant toxicity against human cells, limi...
-
作者：Zhang, Xin; Wu, Dongxue; Clark, William A. V.
作者单位：Southwest Minzu University; Chengdu University of Information Technology; University of California System; University of California Los Angeles
摘要：Declining fertility and the emergence of very low TFR's in the Asian economies has increased the focus on how to change the direction of the fertility trend. Several countries in Europe and Asia have explored a variety of stimulus packages to increase the overall TFR. In this research we review those policies and examine one of those interventions which has the potential to stimulate fertility-the role of access to housing. The core of housing approaches to stimulating fertility is to make hou...
-
作者：Kitazawa, Munehiro; Yamaura, Yuichi; Kawamura, Kazuhiro; Senzaki, Masayuki; Nakamura, Futoshi
作者单位：National Institute for Environmental Studies - Japan; Hokkaido University; Forestry & Forest Products Research Institute - Japan; Forestry & Forest Products Research Institute - Japan; Hokkaido University
摘要：Reversing biodiversity declines will require redesigning agricultural landscapes and their management. Farmland abandonment and intensification are emerging as major drivers of biodiversity changes, and their consequences vary widely from negative to positive among continents. Despite decades of research on agricultural biodiversity, no generalizable framework has been established to predict these variations globally, hindering the development of effective conservation strategies. Here, we com...
-
作者：McNutt, Marcia; Stofan, Ellen
作者单位：National Academies of Sciences, Engineering & Medicine; Smithsonian Institution
