31期

最新文章

• The floral illusion: A parasitic beetle mimics the scent of flowers to attract bees AI翻译
  作者：Alam, Ryan M.; Kessler, Danny; Vogel, Heiko; Luck, Katrin; David, Anja; Kunert, Maritta; Brehm, Gunnar; Kaltenpoth, Martin; O'Connor, Sarah E.; Kollner, Tobias G.
  作者单位：Max Planck Society; Max Planck Society; Friedrich Schiller University of Jena
  摘要：Animals are not known to biosynthesize floral chemical signals to manipulate pollinators, although such mimicry could profoundly shape plant-pollinator interactions. Larvae of the poisonous European blister beetle Meloe proscarabaeus parasitize multiple solitary bee species, yet the mechanism enabling host attraction has remained unresolved. Here we show that these larvae lure bees by emitting a bouquet of volatile compounds that closely resembles floral scent. Chemical analyses reveal a compl...
• Dual control of PIP2 drives germline/soma segregation in Drosophila AI翻译
  作者：Kilwein, Marcus D.; Yang, Liu; Marmion, Robert A.; Wynter, Char A.; Nakamura, Akira; Shvartsman, Stanislav Y.; Gavis, Elizabeth R.
  作者单位：Princeton University; Princeton University; Kumamoto University; Kumamoto University; Simons Foundation; Flatiron Institute
  摘要：Embryonic cell fate decisions require precise spatial coordination between competing lineage determinants. In the syncytial Drosophila embryo, primordial germ cells (PGCs) and posterior endoderm are specified at the posterior pole in overlapping domains, creating a conflict between germline and somatic fates. PGC formation depends on germ granules, which locally promote production of the phospholipid PIP2 at the posterior plasma membrane. PIP2 regulates actin dynamics leading to membrane protr...
• Distinct prelimbic cortex ensembles encode response execution and inhibition (vol 122, e2505378122, 2025) AI翻译
  作者：Madangopal, Rajtarun; Zhao, Yuan; Heins, Conor; Zhou, Jingfeng; Liang, Bo; Barbera, Giovanni; Lam, Ka Chun; Komer, Lauren E.; Weber, Sophia J.; Thompson, Drake J.; Gera, Yugantar; Pham, Diana Q.; Savell, Katherine E.; Warren, Brandon L.; Caprioli, Daniele; Venniro, Marco; Bossert, Jennifer M.; Ramsey, Leslie A.; Jedema, Hank P.; Schoenbaum, Geoffrey; Lin, Da-Ting; Shaham, Yavin; Pereira, Francisco; Hope, Bruce T.
• Cryoelectron tomography reveals an age-related decline in mitoribosomes that contributes to T cell dysfunction in older individuals AI翻译
  作者：Chen, Jingwen; Su, Lili; Pan, Bangze; Sang, Junhao; Li, Linlin; Huang, Junsong; Hu, Zhao-Lan; Wang, Lixin; Zhang, Xiaojie; Jin, Jun
  作者单位：Fudan University; ShanghaiTech University; ShanghaiTech University; Central South University; Fudan University
  摘要：Mitochondrial dysfunction drives T cell aging in mice. Yet, due to fundamental differences in T cell aging mechanisms between species, whether human T cells exhibit similar mitochondrial alterations remains unclear, with existing evidence often conflicting. Using cryoelectron tomography, we resolved the structure and spatial organization of mitochondrial ribosomes in primary human CD8+ T cells under physiological conditions. Comparative analysis with human aging models revealed an age-related ...
• Susceptibility and regulation of biomolecular condensates by solutes AI翻译
  作者：Matsuzawa, Takumi; Varma, Kaarthik; Bate, Teagan; Lorenz, Charlotta; Larina, Katherine; Bauermann, Jonathan; Matthias, Dana; Grubic, Tarik; Style, Robert W.; Steinmetz, Michel O.; Dufresne, Eric R.
  作者单位：Cornell University; Harvard University; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; University of Basel; Cornell University
  摘要：Metabolites are abundant in cells, where condensation of proteins and nucleic acids can organize cellular contents without membranes. Condensates form and dissolve dynamically in response to diverse cellular processes. Understanding condensate phase behavior using full phase diagrams is hampered by the sheer number of distinct molecular species involved. To circumvent this limitation, we introduce susceptibility, a dimensionless descriptor that quantifies dilute-phase responses to solute pertu...
• Rethinking energy transition strategies for the European Union amid rising energy prices (Vol 123, e2609606123, 2026) AI翻译
  作者：Meng, Wenjun; Nieto, Jaime; Guan, Dabo; Meng, Jing; Sander, Robert; Poschl, Ulrich; Hubacek, Klaus; Su, Hang; Tao, Shu; Cheng, Yafang
• Discovery of a phenazine-thiol conjugase from sparse data using genome-informed machine learning AI翻译
  作者：Shan, Xiaoyu; Trindade, Ines B.; Glasser, Nathaniel R.; Thalhammer, Korbinian O.; Scurria, Matthew; Mora, Ariane; Conway, Stuart J.; Newman, Dianne K.
  作者单位：California Institute of Technology; California Institute of Technology; California Institute of Technology; University of California System; University of California Los Angeles; Austrian Academy of Sciences
  摘要：Machine learning has enabled powerful biological discoveries using models trained on large datasets. However, for many important biological questions, such as identifying enzymes that transform understudied substrates, sparsity of training data is often a major bottleneck. Here, using phenazine natural products as a case study, we show that integrating genome-informed data augmentation with contrastive learning in protein language space enables identification of phenazine-interacting proteins ...
• Guanylate kinase 1 is an enzyme responsible for inosine accumulation in RNA of mammalian cells deficient in inosine triphosphatase AI翻译
  作者：Tsuchimoto, Daisuke; Takiguchi, Yuka; Nakabeppu, Yusaku
  作者单位：Kyushu University; Kyushu University
  摘要：Inosine triphosphate (ITP) is a noncanonical nucleotide. Human cells possess inosine triphosphate pyrophosphatase (ITPA), and ITPA deficiency causes ITP accumulation within cells, leading to the onset of Developmental and Epileptic Encephalopathy 35. Two potential pathways for ITP biosynthesis have been proposed: i) oxidative deamination of the adenine base in adenosine triphosphate or ii) a two-step phosphorylation reaction of inosine monophosphate (IMP), an intermediate in the de novo synthe...
• Long-horizon associative learning as a unifying framework for statistical learning across scales AI翻译
  作者：Benjamin, Lucas; Flo, Ana; Al Roumi, Fosca; Dehaene-Lambertz, Ghislaine
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; CEA
  摘要：Sensory inputs are rich with temporal patterns that unfold across multiple timescales. Uncovering these regularities is essential for anticipating future events and navigating the environment efficiently. Numerous models have been proposed to account for learning at specific temporal scales; however, they are often designed in isolation and rely on narrowly tuned statistical measures, limiting their generalizability to other paradigms. In contrast, humans typically learn without prior knowledg...
• Social dynamics of AI adoption in parents' educational decisions AI翻译
  作者：Bursztyn, Leonardo; Imas, Alex; Jimenez-Duran, Rafael; Leonard, Aaron; Roth, Christopher
  作者单位：University of Chicago; University of Chicago; Bocconi University; University of Cologne
  摘要：When adopting a performance-enhancing technology offers short-run relative advantages, competitive pressure can drive diffusion even if most adopters would prefer a collective ban. We study this dynamic in the context of unrestricted AI tools for teenagers' education. In preregistered, incentive-compatible experiments with approximately 2,000 parents in the United States, Canada, and the United Kingdom, we elicit willingness to pay for a three-month premium subscription to a leading general-pu...