31期

最新文章

• PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer AI翻译
  作者：Rao, Xiongjian; Allison, Derek B.; Flight, Robert M.; Lin, Penghui; He, Daheng; Li, Zhiguo; Zhang, Yanquan; Wang, Ruixin; Li, Chaohao; Wang, Jianlin; Wang, Xinyi; Peng, Jia; Fong, Ka Wing; Shao, Qing; Wang, Chi; Ali, Eunus S.; Moseley, Hunter N. B.; Liu, Xiaoqi
  作者单位：University of Kentucky; University of Kentucky; University of Kentucky; University of Kentucky; University of Kentucky; University of Kentucky; University of Kentucky
  摘要：Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to meet their increased biosynthetic and energetic demands. Although cells possess the capacity for de novo serine biosynthesis, most transformed cancer cells preferentially rely on exogenous serine uptake to sustain their growth, yet the regulatory mechanisms driving this metabolic dependency remain poorly understood. Here, we uncover a mechanism by which Polo-like kinase 1 (PLK1), frequently overexpressed in prostate cance...
• Proteolytic activation of c-MYC facilitated by DOT1L AI翻译
  作者：Sepulveda, Gian P.; Nawalaniec, Karol; Nikorich, Iana; Guschanskaia, Ekaterina S.; Mora-Martin, Alexandra; Esse, Ruben; Ceballos, Ainhoa; Xia, Chaoshuang; Kwan, Julian; Blum, Benjamin C.; Emili, Andrew; Cardamone, Maria D.; Perissi, Valentina; Costello, Catherine E.; Grishok, Alla
  作者单位：Boston University; Boston University; Columbia University; Boston University; Boston University; Boston University; Boston University
  摘要：c-MYC is a key regulator of growth and metabolism. Functional and molecular cooperation between the H3K79 methyltransferase DOT1L and c-MYC has been reported in several human cancer types, but the nature of their interaction remains undefined. We demonstrate that DOT1L and MYC [Myc and Mondo-like (MML-1) in Caenorhabditis elegans] coregulate genes in the nematode model and mammalian cancer cells. Moreover, both c-MYC and MML-1 exhibit cleavage products facilitated by DOT1L function. Surprising...
• Liver sinusoidal endothelium mediates systemic clearance of ultrasmall gold nanoparticles through secretion of circulating exosomes AI翻译
  作者：Tan, Yue; Mo, Luoqi; Luo, Caiming; Tang, Jiahao; Zhou, Yuxuan; Liu, Jinbin
  作者单位：South China University of Technology
  摘要：Liver sinusoidal endothelium featuring a unique discontinuous lining and robust endocytic activity is vital for nanoparticle retention, clearance, and translocation. However, liver sinusoidal endothelium-mediated nanoparticle elimination remains far less understood than liver macrophage uptake despite both processes being involved in hepatic detoxification. Using water-soluble Au25(o-MBA)18 (o-MBA: o-mercaptobenzoic acids) with optimized local hydrophobicity for weak protein-binding affinity a...
• PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and Gαq AI翻译
  作者：Falzone, Maria E.; Banerjee, Priyam; MacKinnon, Roderick
  作者单位：Rockefeller University; Rockefeller University; Rockefeller University; University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas at San Antonio
  摘要：PLC beta enzymes cleave PIP2 from the plasma membrane, producing IP3 and DAG, which regulate intracellular Ca2+ levels and protein kinase C activity, respectively. They are regulated by GPCR signaling through the G proteins G beta gamma and G alpha q and have been shown to function as coincidence detectors for dual stimulation of G alpha q- and G alpha i-coupled receptors via these G proteins. PLC beta s are aqueous-soluble enzymes, but partition onto the membrane surface to access their lipid...
• AI will reorganize science. Will research remain a human enterprise? AI翻译
  作者：Hochberg, Michael E.; Thrall, Peter H.
  作者单位：Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; The Santa Fe Institute
• Structures of the sodium-coupled phosphate importer SLC34A2 reveal a distinct architecture and gating mechanism AI翻译
  作者：Zhu, Qinyu; Almakki, Omar; Diver, Melinda M.
  作者单位：Memorial Sloan Kettering Cancer Center
  摘要：Dysregulation of inorganic phosphate (Pi) homeostasis contributes to metabolic disease, cancer, pathological calcification, and kidney disease. Systemic phosphate balance is regulated by SLC34 transporters that mediate renal Pi retention (SLC34A1/A3) and intestinal dietary Pi absorption (SLC34A2). SLC34s couple Pi uptake to the symport of sodium (Na+) down its electrochemical gradient. Mutations or altered expression of SLC34 proteins are linked to disorders such as chronic kidney disease, whe...
• A generative model for bipartite gene-sharing networks AI翻译
  作者：Iranzo, Jaime; Jodar, Pedro; Koonin, Eugene V.; Manrubia, Susanna; Cuesta, Jose A.
  作者单位：University of Zaragoza; Universidad Carlos III de Madrid; National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM); Division of Intramural Research (DIR); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Museo Nacional de Ciencias Naturales (MNCN)
  摘要：Gene-sharing networks provide a powerful framework to study the evolution of viruses and mobile genetic elements. These bipartite networks, which link genes to the genomes that contain them, exhibit characteristic degree distributions: a scale-free distribution for genes and an exponential-like decay for genomes. Here, we propose a mechanistic model that explains these patterns through fundamental evolutionary processes including horizontal gene transfer, capture of new genes, emergence of new...
• Paramyxovirus infection driven by heteromultivalent sialoglycotope binding (vol 123, e2530862123, 2026) AI翻译
  作者：Wu, Xuesheng; Liu, Mengying; Blekkenhorst, Laura; Verbruggen, Mare H. L.; Schuurman, Nancy N. M. P.; Chao, Lemeng; Ong, Jun Yang; Wennekes, Tom; van Dijk, Laura L. A.; de Vries, Rory D.; van Kuppeveld, Frank J. M.; Clausen, Henrik; Narimatsu, Yoshiki; de Vries, Erik; de Haan, Cornelis A. M.
• Heat tolerance decreases and cold tolerance increases with elevation for a species-rich insect family on a tropical volcano AI翻译
  作者：Loureiro, Alexandre M. M. C.; Hallwachs, Winnie; Janzen, Daniel H.; Smith, M. Alex
  作者单位：University of Guelph; University of Pennsylvania
  摘要：The climate crisis is moving the high ambient temperatures common in lower elevation tropical forests upslope into areas where they would not have occurred historically. Tropical invertebrates may be particularly vulnerable to such changes. Here, our goal was to understand whether the distribution of heat and cold tolerances along an elevational gradient in northwestern Costa Rica predicted by theory were present for a leaf-litter inhabiting insect community of rove beetles (Staphylinidae: Col...
• A demographic theory of similarity-biased social learning AI翻译
  作者：Velilla, Alejandro Perez; Smaldino, Paul E.
  作者单位：University of California System; University of California Merced; Max Planck Society; The Santa Fe Institute
  摘要：We develop a demographic theory of similarity-biased social learning that formalizes our understanding of when and why individuals should preferentially copy others that look or act like them. We build an evolutionary model in which individuals can either learn on their own or copy others from a demonstrator pool that contains varying proportions of in-group and out-group members, and where group tags can be more or less informative about local knowledge. We find that where social learning bec...