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作者：Gong, Qianqian; Lv, Zhuowen; Dou, Zhilin; Wang, Sen; Zhang, Keyi; Guo, Yuyu; Wang, Yingying; Shao, Ming; Su, Ling; Liu, Xiangguo; Sun, Xiaoyang
作者单位：Shandong University; Shandong University; Shandong University; Shandong University; Shandong University; Shandong University
摘要：Defects in multiciliated ependymal cells (ECs), which line the cerebral ventricular walls and generate unidirectional cerebrospinal fluid (CSF) flow through coordinated ciliary beating, can lead to CSF accumulation and hydrocephalus. TMEM216, a ciliopathy-associated gene mutated in Joubert, Meckel, and related syndromes, encodes an essential component of the protein complexes that form the transition zone (TZ) at the base of primary cilia. Here, we demonstrate that central nervous system-speci...
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作者：Hahn, Michael; Wang, Entang; Wei, Xue-Xin
作者单位：Saarland University; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
摘要：Inferring the underlying computational processes from behavioral measurements is a fundamental approach in cognitive science and neuroscience. Although Bayesian decision theory has become a major normative framework for modeling perception and cognition, it is unclear to what extent its modeling components (i.e., prior belief, likelihood function, and loss function) can be recovered from behavioral data. Here, we systematically investigated the problem of inferring such Bayesian models from be...
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作者：Li, Hao; Liu, Bing; Liu, Jiaying; Mangeat, Thomas; Belguise, Karine; Xue, Shi-Lei; Wang, Xiaobo
作者单位：Communaute d'universites et etablissements de Toulouse (Comue); Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse (EPE); Westlake University
摘要：Pulsatile actomyosin networks emerge as a widespread mechanism driving tissue morphogenesis. Compared with myosin-II pulses, F-actin pulses are largely unexplored. By studying Drosophila oogenesis, we report that basal pulsatile actomyosin networks consist of F-actin bundle and meshwork architectures, implicating the existence of different F-actin microstructures and corresponding nucleators. Here, Rac1 and the Scar/WAVE-Arp2/3 complex (branched F-actin nucleator), exhibiting constant levels, ...
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作者：Li, Tiewei; Chen, Hans W.; Chen, Deliang; Xiao, Jingfeng; Guo, Lanlan; Liu, Lianyou; Shi, Feng; Yuan, Wenping; Zhong, Ziqian; Zheng, Huan; He, Bin
作者单位：Tsinghua University; Chalmers University of Technology; Tsinghua University; University System Of New Hampshire; University of New Hampshire; Beijing Normal University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Geology & Geophysics, CAS; Peking University
摘要：With global warming, rising atmospheric vapor pressure deficit (VPD) has emerged as a critical driver of vegetation productivity and the terrestrial carbon sink. Yet, the thresholds beyond which VPD constrains tree growth remain poorly quantified. Using 2,953 tree-ring sites and combining generalized additive models with threshold regression models, we demonstrate that growth-related VPD thresholds are widespread. Approximately 63% of the studied species groups exhibited identifiable threshold...
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作者：Shinkai, Soya; Namba, Toshinori; Sugawara, Takeshi; Hagiwara, Soya; Onami, Shuichi; Haraguchi, Tokuko; Hiraoka, Yasushi; Awazu, Akinori; Ueno, Masaru; Tate, Shin-ichi
作者单位：RIKEN; Hiroshima University; University of Osaka; Hiroshima University; Hiroshima University
摘要：Genome organization in the nucleus is highly structured and dynamic. Recent advances in genomic technology have enabled the measurement of genome-wide architecture and locus-specific motion, yielding contact maps and live-cell trajectories. However, these outcomes are derived from different modalities and are not directly comparable, with their quantitative integration being a key challenge. Here we establish a genome-wide live-cell imaging platform in fission yeast Schizosaccharomyces pombe, ...
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作者：Friedman, Jeffrey M.
作者单位：Rockefeller University
摘要：In an extraordinary convergence, Emmanuel Mignot and Masashi Yanagisawa employed two entirely different approaches to establish the pathogenesis of narcolepsy, a devastating sleep disorder associated with overwhelming sleep attacks, cataplexy, episodes with sudden loss of muscle tone, and hallucinations resulting from dreaming while awake. Yanagisawa purified brain ligands for orphan G protein-coupled receptors identifying a peptide, orexin, and then used reverse genetics to show that a knocko...
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作者：Jiang, Qingyang; Xu, Ruiquan; Lin, Zhixin; Sun, Chenyu; Ye, Feidi; Ye, Yanyan; Lin, Duoming; Li, Zhen; Mai, Jingwen; Lin, Zhihong; Qu, Jiuxin; Deng, Xiaoyan; Ge, Chenchen; Wang, Dou
作者单位：Guangzhou Medical University; Shenzhen Technology University
摘要：CRISPR-based diagnostics (CRISPR-Dx) integrated with isothermal nucleic acid amplification have emerged as a promising strategy for point-of-care molecular testing. Their practical deployment, however, remains constrained by workflow-related limitations. Conventional two-step formats are laborious and highly susceptible to aerosol contamination during amplicon transfer, whereas simplified one-pot formats often suffer from reduced sensitivity because amplification and CRISPR-mediated cleavage c...
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作者：Li, Linjie; Nguyen, Linh; Qu, Hao; Wu, Qile; Gao, Pengyue; Li, Dedong; Li, Xinyu; Liu, Xueyuan; Jiang, Qiuyao; Liu, Kefang; Wong, Catherine C. L.; Gao, George Fu
作者单位：Chinese Academy of Sciences; Institute of Microbiology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Liaoning University; Shandong University; Shandong First Medical University & Shandong Academy of Medical Sciences; Beijing Life Science Academy; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College Hospital; Tsinghua University
摘要：SARS-CoV-2 continues to evolve. The subvariant BA.3.2 (Cicada), a derivative of the Omicron BA.3 subtype first detected in late 2024, harbors multiple spike protein mutations, ORF7 and ORF8 deletions, and has recently evolved sublineages (BA.3.2.1 and BA.3.2.2), rendering it a critical target for epidemiological surveillance. The BA.3.2.2 sublineage, represented by RE.2.2, shows a marked upward trend in late 2025. Using surface plasmon resonance, we found that RE.2.2's spike (S) protein recept...
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作者：Orpella, Joan; Mantegna, Francesco; Oderbolz, Chantal; Assaneo, M. Florencia; Poeppel, David
作者单位：Georgetown University; New York University; University of Oxford; Universidad Nacional Autonoma de Mexico; New York University
摘要：Inner speaking-the deliberate generation of speech through covert production mechanisms-is a common human experience. Current accounts propose that it engages sensorimotor processes similar to those underlying overt speech. Here, we asked whether motor and auditory representations during inner speaking maintain the granularity and temporal structure observed in overt speech. Using magnetoencephalography and time-resolved decoding, we examined neural dynamics across two experiments. Participant...
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作者：Pao, William
摘要：The 2026 Lasker similar to DeBakey Clinical Medical Research Award has been awarded to Kunihiro Hattori, Takehisa Kitazawa, and Tomoyuki Igawa (Chugai Pharmaceuticals, Tokyo, Japan) for invention of a bispecific antibody that joins blood clotting Factors IXa (FIXa) and X (FX), restoring deficient Factor VIII (FVIII) activity in patients with hemophilia A and preventing severe bleeding in this hereditary disorder. Starting from the 1960s, types of FVIII-replacement therapy remarkably improved o...
