37期

最新文章

• Negative feedback regulation of karrikin signaling in Arabidopsis thaliana by an antagonistic paralog of karrikin receptors AI翻译
  作者：Li, Qingtian; Chang, Sun Hyun; Tuckey, Andrew; Sepulveda, Claudia; Varshney, Kartikye; Li, Dan; Gutjahr, Caroline; Waters, Mark T.; Nelson, David C.
  作者单位：University of California System; University of California Riverside; Yazhouwan National Laboratory; University of Western Australia; Max Planck Society
  摘要：Karrikins (KARs) are a class of butenolide molecules discovered in smoke hypothesized to mimic an undiscovered plant hormone, KAI2 ligand (KL). KAR/KL signaling regulates germination, seedling development, stress tolerance, and symbiotic interactions with soil microbes, among other traits. KAR/KL signaling is initiated by KARRIKIN INSENSITIVE2 (KAI2), an alpha/beta-hydrolase related to the strigolactone enzyme-receptor DWARF14 (D14). Activated KAI2 forms protein-protein interactions that trigg...
• Lysosomal reduced thiols are essential for mouse embryonic development (vol 122, e2427125122, 2025) AI翻译
  作者：Adelmann, Charles H.; Venkatachalam, Avanthika; Huang, Lingjuan; Liu, Michelle; Germana, Sharon; Harry, Stefan A.; Rosen, Paul C.; Herron, Joshua; Tien, Pei-Chieh; Bar-Peled, Liron; Sabatini, David M.; Fisher, David E.
• Transthyretin can denature by an alternative pathway AI翻译
  作者：Jager, Marcus; Schafer, Jan-Hannes; Lander, Gabriel C.; Powers, Evan T.; Gruebele, Martin; Kelly, Jeffery W.
  作者单位：Scripps Research Institute; Scripps Research Institute; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Transthyretin (TTR) is a kinetically stable protein in the bloodstream, cerebrospinal fluid, and in the eye, whose aggregation causes a prominent human amyloid disease, TTR amyloidosis (ATTR). Dissociation of the wild-type TTR tetramer into metastable dimers is rate-limiting for aggregation at acidic pH and unfolding in denaturant solutions at neutral pH. However, this canonical dimer pathway of denaturation is not the only one accessible under conditions possibly relevant to amyloid disease. ...
• Plausible nonsense and deliberative reasoning: Benchmarking LLMs against human judgment AI翻译
  作者：Veri, Francesco; Kreia Umbelino, Gustavo
  作者单位：FHNW University of Applied Sciences & Arts Northwestern Switzerland; University of Zurich
  摘要：Large Language Models (LLMs) are entering democratic contexts as instruments of governance, where the challenges at hand are ill-structured, marked by ambiguity and contestation. Ill-structured democratic problems demand more than factual precision; they call for intersubjective reasoning: context-sensitive judgments that others can understand and publicly accept. Using the Deliberative Reason Index (DRI), this study evaluates 60 LLMs against human deliberation across nine policy scenarios. On...
• In vivo genome-wide CRISPR screens identify FOXR1 as a suppressor of CD8+ T cell antitumor immunity AI翻译
  作者：Yang, Xue; Ouyang, Han; Xu, Henan; Peng, Lingxiao; Cui, Jianzhou; Zhang, Bin; Huang, Bo; Wang, Chunmei; Li, Guideng; Cao, Xuetao
  作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Nankai University
  摘要：T cell dysfunction critically limits the efficacy of T cell-based immunotherapies in solid tumors, yet the intrinsic regulators of T cell dysfunction remain incompletely understood. Through an in vivo genome-wide CRISPR screen in tumor-infiltrating CD8+ T cells, we identified Forkhead Box R1 (FOXR1) as a potent transcriptional suppressor of CD8+ T cell effector functions. Genetic ablation of FOXR1 significantly enhanced cytokine production and cytotoxic capacity in both murine and human CD8+ T...
• Size-tailored nanoparticle-antibody conjugates overcome hepatic sequestration in Alzheimer's disease treatment AI翻译
  作者：Du, Xuewei; Liu, Ni; Zhang, Taoping; Yang, Changwen; Luo, Haiming
  作者单位：Hainan University; Huazhong University of Science & Technology
  摘要：Antibody-based immunotherapy targeting amyloid-beta (A beta) is a promising approach for Alzheimer's disease (AD). However, its efficacy is limited by rapid hepatic sequestration, complement activation, and liver dysfunction. In this study, we synthesized low-immunogenic 450-nm functionalized mesoporous silica nanoparticles (PEG-MSN-1F12) by conjugating the anti-A beta 42 monoclonal antibody 1F12 to polyethylene glycol-modified mesoporous silica nanoparticles to address these challenges. In AP...
• Correction for Sepulveda et al., Proteolytic activation of c-MYC facilitated by DOT1L (vol 123, e2525603123, 2026) AI翻译
  作者：Sepulveda, Gian P.; Nawalaniec, Karol; Nikorich, Iana; Guschanskaia, Ekaterina S.; Mora-Martin, Alexandra; Esse, Ruben; Ceballos, Ainhoa; Xia, Chaoshuang; Kwan, Julian; Blum, Benjamin C.; Emili, Andrew; Cardamone, Maria D.; Perissi, Valentina; Costello, Catherine E.; Grishok, Alla
• Minimal-length CAG repeats in AR define a hyperactive AR-LSD1 axis driving metabolic reprogramming in prostate cancer AI翻译
  作者：Zhang, Songqi; Li, Muqing; Liu, Mingyu; Patten, Nolan D.; Labaf, Maryam; Jeong, Jaeweon; Sun, HyeonYeong; Lourie, Jared; Zou, Kai; Patalano, Susan; Mulhearn, Michaela J.; Macoska, Jill A.; Gao, Shuai; Andreotti, Roberta; Pennuto, Maria; Han, Dong; Balk, Steven P.; Cai, Changmeng
  作者单位：University of Massachusetts System; University of Massachusetts Boston; University of Massachusetts System; University of Massachusetts Boston; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; University of Massachusetts System; University of Massachusetts Boston; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; University of Massachusetts System; University of Massachusetts Boston; New York Medical College; University of Padua; Veneto Institute Molecular Medicine
  摘要：The polymorphic CAG trinucleotide repeat in the androgen receptor (AR) gene encodes a variable-length N-terminal polyglutamine (polyQ) tract that modulates AR transcriptional activity, with shorter tracts generally enhancing AR activity. While the majority of men harbor CAG repeats longer than 17, a small subset carry minimal-length CAG repeats (<= 17) in AR. These alleles are primarily found in men of African ancestry, accounting for over 10% of the population, and may significantly contribut...
• Coadapting but not static predators facilitate prey adaptation to a fluctuating environment AI翻译
  作者：Guyot, Lou; Ramachandran, Aryan; Chevin, Luis-Miguel
  作者单位：Universite Paul-Valery; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Universite PSL; Institut Agro; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro Montpellier; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); AgroParisTech; Ecole Normale Superieure de Lyon (ENS de LYON)
  摘要：Understanding how between-species interactions influence adaptation and population persistence in the face of environmental change is one of the greatest challenges for modern ecology and evolution, with important implications for conservation, and other applied fields. As predation is ubiquitous and may have strong demographic and selective impacts, it is likely to alter how prey respond to a changing environment. However, whether and how adaptation in prey depends on the way selection operat...
• Seasonally asymmetric warming reshapes grassland stability across timescales AI翻译
  作者：Lu, Chunyan; Liu, Huiying; Huang, Yixuan; Zhang, Jingya; Zhang, Juanjuan; Gao, Siyuan; Zhang, Zhenhua; Wang, Hao; He, Jin-Sheng; Thakur, Madhav P.
  作者单位：East China Normal University; University of Bern; Chinese Academy of Sciences; Lanzhou University; Lanzhou University
  摘要：Climate change can alter ecosystem stability, yet how seasonally asymmetric warming or drought reshapes stability across timescales remains unresolved. To address this, we conducted two multiyear field experiments in Tibetan alpine grasslands, investigating how season-specific warming or drought alters the seasonal and interannual stability of plant community biomass. Spring warming increased both seasonal and interannual stability, whereas year-round warming only enhanced seasonal stability. ...