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作者：van der Horst, Sjors; Gage, Joseph L.; Bailey-Serres, Julia
作者单位：University of California System; University of California Riverside; University of California System; University of California Riverside; Wageningen University & Research; North Carolina State University; North Carolina State University
摘要：Ribosomes can pause during mRNA translation, but what causes pausing, how pauses affect protein production, and whether they trigger cotranslational mRNA decay are poorly understood in plants. Here, we investigate the causes and consequences of ribosome pausing in Arabidopsis and maize. This is accomplished by sizing, mapping, and quantifying footprints of individual ribosomes (monosomes) and closely spaced ribosome pairs (disomes) at single-codon resolution on open reading frames (ORFs). Ribo...
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作者：Zhang, Ling; Ye, Quanliang; Kharrazi, Ali; Huang, Qingxu; Wu, Jiansheng; Fath, Brian
作者单位：Peking University Shenzhen Graduate School (PKU Shenzhen); Peking University; Peking University; International Institute for Applied Systems Analysis (IIASA); Tianjin University; Beijing Normal University; Beijing Normal University; University System of Maryland; Towson University
摘要：Rapid globalization and its accordant supply chains accelerates biodiversity loss. Yet timely assessments of biodiversity status and trends remain insufficient, limiting effective conservation actions in response to supply chain dynamics. Here, we provide a three-decade-long analysis of status and trends of three main biodiversity threats and 21,207 threatened species along production, trade, and final consumption between 185 countries. Results show escalating trends and newly identified threa...
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作者：Qi, Ke; Jin, Suoqin; Ma, Han; Wang, Tengfei; Lou, Yijun; Nie, Qing; Zou, Xiufen
作者单位：Wuhan University; Hong Kong Polytechnic University; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine
摘要：The spatial patterns of immune cells within the tumor microenvironment hold profound prognostic implications, yet a mechanistic understanding of their formation and functional impact remains lacking. Current mechanistic models operate in a theoretical vacuum, while spatial transcriptomics (ST) provides static snapshots without dynamic insight. To bridge this gap, we present an integrative framework that couples a reaction-diffusion model of tumor-immune kinetics with multicohort ST data. We th...
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作者：Shen, Pengfei; Zhang, Yidong; Wang, Huai; Zhang, Xiaolin; Pan, Bingcai
作者单位：Nanjing University; Nanjing University
摘要：Fixed-bed adsorption is a widely adopted method for the removal of diverse aqueous pollutants at the industrial scale, including oxyanions such as arsenite [As(III)], arsenate [As(V)], and phosphate [P(V)]. However, owing to the inherently unsteady operating conditions, effective strategies that synergistically coregulate thermodynamics and kinetics to enhance adsorption performance remain limited. Here, we propose a generalizable approach that leverages a built-in electric field (BEF) around ...
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作者：Domozych, David S.
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作者：Epstein, Ruth; Wheeler, J. J.; Hubisz, Melissa J.; Zhai, Jingjing; Lai, Wei-Yun; Fairbanks, Regina A.; Sun, Qi; Buckler, Edward S.; Pawlowski, Wojciech P.
作者单位：Cornell University; Cornell University; University of California System; University of California Davis; University of California System; University of California Davis; United States Department of Agriculture (USDA); USDA Agricultural Research Service
摘要：Despite the plethora of knowledge about the benefits of meiotic recombination and numerous theoretical studies examining how recombination rates evolve, there is a general lack of empirical support and consensus across species. To fill this knowledge gap, we characterized the evolution of recombination landscape in maize during its domestication from teosinte and related the observed changes to established theoretical frameworks. Through examining recombination in experimental populations of m...
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作者：Holowka, Nicholas B.; O'Neill, Matthew C.; Bhandal, Vincent; Lam, Otto; Apolito, Zacchariah M.; Massimi, Caleb A.; Palmisano, Kevin G.; Worthington, Steven; Demes, Brigitte; Thompson, Nathan E.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; State University of New York (SUNY) System; University at Buffalo, SUNY; State University of New York (SUNY) System; Stony Brook University; Stony Brook University Hospital; Icahn School of Medicine at Mount Sinai; Harvard University; New York Institute Technology
摘要：The human walking step is initiated by a distinctive heel-strike. Our closest living relatives, the African apes, are among the few other animals that are also thought to heel-strike. Qualitative similarities between human and African ape heel-strikes have been invoked in theories about the origins of hominin bipedalism, but some quantitative data suggest possible interspecies differences in foot-strike mechanics that hint at more complex evolutionary scenarios. However, these data are current...
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作者：Melnykov, Artem V.
摘要：The genetic code is conserved across all domains of life and is often described as universal. Nevertheless, many exceptions to the universal code have now been documented, most of these through manual or semiautomated inspection of highly conserved genes. Modern bioinformatics tools improved our ability to find alternative genetic codes but remain computationally expensive, preventing widespread use on thousands of new species identified by sequencing environmental samples. Here, I report a >1...
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作者：Sun, Xueyi; Zhu, Chunchun; Liu, Wen; Wang, Zixuan; Deng, Hongyan; Jia, Shuke; Shi, Shuai; Xiang, Yuhan; Luo, Yiman; Gui, Jian-Fang; Liu, Xing; Xiao, Wuhan
作者单位：Chinese Academy of Sciences; Institute of Hydrobiology, CAS; Hubei Hongshan Laboratory; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：The mitochondrial antiviral signaling protein (MAVS) is a key component of the innate immune response against RNA viruses. Its involvement in other cellular stresses is largely unknown. Here, we found that hypoxia induces MAVS aggregation, leading to the stabilization of HIF1/2 alpha proteins and the enhancement of hypoxia signaling. Mechanistic studies revealed that MAVS enhances TRAF6 binding to ECSIT, which catalyzes ECSIT polyubiquitination. This promotes mitochondrial ROS generation and l...
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作者：Goldstein, Joseph L.
作者单位：University of Texas System; University of Texas Southwestern Medical Center
摘要：Many groundbreaking works in art and science owe their origins to the creative spark ignited by reimagination-the process whereby artists and scientists reinterpret and reframe past and existing knowledge, envisioning it in a new context that reveals new possibilities. Artistic and scientific innovation originating from reimagination brings to mind William Faulkner's famous line, The past is never dead. It's not even past. [W. Faulkner, Requiem for a Nun (1)].
