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作者：Velle, Katrina B.; Ramaswamy, Meera; Hokmabad, Babak Vajdi; Martin-Perez, Tania; Carrasco, Teodoro Tapia; Callahan, William S.; Kim, Harrison S.; Larkin, Emily M.; ElZafarany, Abdurrahman H.; Jacques, Samantha M.; Datta, Sujit S.; Edwards, Marc; Fritz-Laylin, Lillian K.
作者单位：University of Massachusetts System; University Massachusetts Dartmouth; University of Minnesota System; University of Minnesota Twin Cities; Princeton University; Princeton University; Universidad de Alcala; Amherst College; Howard Hughes Medical Institute; University of Massachusetts System; University of Massachusetts Amherst; University of Massachusetts System; University of Massachusetts Amherst; California Institute of Technology
摘要：The brain-eating amoeba Naegleria fowleri dwells in ponds where it normally feeds on bacteria, but if it enters the brain it can cause a deadly infection. To establish infection, N. fowleri must migrate through different environments-along olfactory axons, through openings in the cribriform plate, and within brain tissue-yet how it does so remains unknown. As a model for N. fowleri migration within these environments, we examine how its nonpathogenic relative, Naegleria gruberi, navigates envi...
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作者：Mukherjee, Kushin; Lessard, Laurent; Gleicher, Michael; Rogers, Timothy T.; Schloss, Karen B.
作者单位：Stanford University; Northeastern University; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of London; University College London
摘要：People are capable of using simple perceptual features such as color to signify complex meanings (perceptual semantics), an important aspect of nonverbal communication. This paper considers the nature and structure of the mental representations that support these abilities, using color semantics as a key example. Prior work has shown that people can judge the strength of association between essentially any color and any concept. Across four experiments we show that such associations express a ...
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作者：Liu, Xiaoxia; Gu, Jiaqi; Chen, Zhaomeng; Chu, Benjamin; Liu, Linxi; Morrison, Tim; Butler, Robert R.; Edelson, Jacob; Li, Jinzhou; Longo, Frank M.; Tang, Hua; Ionita-Laza, Iuliana; Sabatti, Chiara; Candes, Emmanuel; He, Zihuai
作者单位：State University of New York (SUNY) System; University at Buffalo, SUNY; State University System of Florida; University of South Florida; Stanford University; Stanford University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Stanford University; National University of Singapore; Stanford University; Columbia University; Stanford University; Stanford University
摘要：Identifying features that interact to trigger disease, while accounting for heterogeneity across diverse populations, is essential for the development of precision and targeted medicine. Despite the availability of vast and complex health-related datasets, most existing works focus on identifying disease-associated features at the population level or within a few subpopulations, often overlooking individual-level heterogeneity within these groups. To address this limitation, we propose a frame...
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作者：Suer, Sena G.; Arnoux, Jerome; Lim, Yi Y.; Dhurve, Ganeshwari; Sen, Rabia; Erdem, Cemal; Mateus, Andre; Avican, Kemal
作者单位：Umea University; Umea University; Umea University; Umea University; Umea University; Umea University; Umea University
摘要：Diverse bacterial pathogens have evolved complex regulatory mechanisms to adapt to various environmental stresses during infection. The uncertainty in mRNA-protein levels in response to environmental stressors complicates our understanding of bacterial physiology and their adaptation to stressful environments. To examine this issue, we have integrated transcriptomics and proteomics data on three human bacterial pathogens: Salmonella enterica Typhimurium, Yersinia pseudotuberculosis, and Staphy...
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作者：Sabour, Sahand; Liu, June M.; Liu, Siyang; Yao, Chris Z.; Cui, Shiyao; Zhang, Wen; Zhang, Xuanming; Cao, Yaru; Bhat, Advait; Guan, Jian; Wu, Wei; Mihalcea, Rada; Wang, Hongning; Althoff, Tim; Lee, Tatia M. C.; Huang, Minlie
摘要：AI assistants are increasingly used as advisors to guide decisions, yet little is known about how people evaluate such advice when the advisor's underlying intent conflicts with their interests. We examine how covert misalignment shapes choices in a randomized experiment (N = 233 participants; 699 observations) in which participants rated financial or emotional decisions before and after consulting one of three AI advisors: a neutral advisor, a misaligned advisor with a hidden objective to pro...
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作者：Testa, Lorenzo; Klei, Lambertus; Rengle, Alesia; Yocum, Anastasia K.; Lewis, David A.; Devlin, Bernie; Roeder, Kathryn; MacDonald, Matthew L.
作者单位：Carnegie Mellon University; University of Washington; University of Washington Seattle; Scuola Superiore Sant'Anna; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Carnegie Mellon University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：A single gene can encode multiple versions of a protein, dubbed isoforms, with varying functionality. Cellular control of isoform abundances is critical for multiple aspects of biology and is only partially regulated by transcript levels. While long-read sequencing facilitates transcript quantification, quantifying the resulting protein isoforms on a large scale is a major challenge, complicating biological interpretation of transcript alterations. Standard bottom up mass spectrometry can asse...
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作者：Van Amburg, Chase; Babel, Drew; Feldman, Marcus W.
作者单位：Stanford University
摘要：Human preferences can shape the genetic evolution of other species via conservation practices, public health actions, and domestication. While the dynamics of domestication have been explored in depth through empirical and theoretical analyses, few studies have analyzed models for the coevolution of human cultural preferences with the genetics of a domesticate population. Humans shape the fitness landscape of domesticate populations both intentionally and unconsciously, by selecting for desira...
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作者：Hong, Sen; Jia, Liangjie; Wang, Rong; Elghobashi-Meinhardt, Nadia; Hobbs, Helen H.; Li, Xiaochun
摘要：The transmembrane 6 superfamily (TM6SF) comprises two members: TM6SF1, a ubiquitously expressed lysosomal membrane protein of unknown function, and TM6SF2, an endoplasmic reticulum protein required for bulk lipidation of Apolipoprotein B-containing lipoproteins. Here, we used cryo-electron microscopy (cryo-EM) to determine the structure of human TM6SF1 at 2.9-& Aring; resolution. TM6SF1 forms a polytopic homodimer, with each protomer comprising 10 transmembrane helices (TMs). TMs 1-6 form a po...
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作者：Koonin, Eugene V.; Krupovic, Mart
作者单位：National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM); Division of Intramural Research (DIR); Universite Paris Cite; Pasteur Network; Institut Pasteur Paris
摘要：Viruses are ubiquitous mobile genetic elements that are obligate symbionts of cellular life forms and replicate exclusively within host cells. The current taxonomy of viruses includes 10 realms (the top rank taxon), 8 of which have small genomes in the range of one to about 60 kilobases and commensurately small virions. However, the two realms of viruses with double-stranded DNA genomes, Varidnaviria and Duplodnaviria, include several groups of viruses known as giant viruses, with genomes reac...
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作者：Frumence, Etienne; Klitting, Raphaelle; Serres, Kyla; Shao, Yucai; Monti, Filippo; Vincent, Muriel; Gill, Mandev S.; Suchard, Marc A.; Lemey, Philippe; de Lamballerie, Xavier; Jaffar-Bandjee, Marie-Christine; Dellicour, Simon
作者单位：Aix-Marseille Universite; Aix-Marseille Universite; Institut de Recherche pour le Developpement (IRD); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Libre de Bruxelles; Vrije Universiteit Brussel; Universite Libre de Bruxelles; University of California System; University of California Los Angeles; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; KU Leuven
摘要：R & eacute;union Island experienced a massive chikungunya virus epidemic in 2024-2025, with >54,000 confirmed cases. This is the second major chikungunya epidemic on the island, following the first one that peaked 20 years ago. It has been asserted that this new outbreak finds its origin in a single introduction event into the island, offering an opportunity to exploit viral genomic data to understand the epidemiological and dispersal dynamics of the introduced transmission chain. We sequenced...
