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作者：Todisco, Marco; Ausler, Christalyn; Jain, Ankur
摘要：RNA is built from a four-nucleotide alphabet. Complementary sequences inevitably arise, creating pervasive opportunities for promiscuous RNA-RNA interactions. Here, we show that this chemistry makes the transcriptome intrinsically prone to self-association. We simulated the simultaneous interactions of similar to 7,500 mRNAs representing the Escherichia coli transcriptome at physiological concentrations. These large-scale simulations predict widespread, dynamic clustering driven by RNA alone a...
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作者：Constant, David A.; Van Winkle, Jacob A.; Norwood, Philip A.; Mishra, Gargi; Meyer, Kimberly A.; Laney, Margaret E.; Madden, Shelby R.; Griffith, Alec; Rodrigues, Patrick Fernandes; Savan, Ram; Nice, Timothy J.
摘要：The healthy intestine maintains homeostasis in part via immune responses to microbiota, which includes basal production of interferon cytokines. Previous work showed that Type III Interferon (IFN-lambda) stimulates localized pockets of interferon-stimulated genes (ISGs) in the adult mouse intestinal epithelium at homeostasis that provide preemptive protection from viral pathogens. Here, we demonstrate that a major source of homeostatic IFN-lambda production in the intestine is a population of ...
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作者：Hou, Xianteng; Wu, Qing; Du, Yangting; Wang, Changwan; Zhu, Junyan; Jiang, Yingbo; Chen, She; Zhou, Lisha; Wu, Xiaoyu; Wang, Hongyan; Yang, Hui; Hou, Fajian
作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; National Institute of Biological Sciences, Beijing; Taizhou University; Fudan University; Fudan University; Fudan University
摘要：The cyclic GMP-AMP synthase-stimulator of interferon genes (STING) pathway is essential for antiviral immunity, and its dysregulation causes inflammatory disease. The mechanism underlying STING activation, including its essential endoplasmic reticulum-to-Golgi translocation, has remained elusive. Here, we identify a dedicated actin-based transport system licensed by the smooth muscle actin isoform ACTA2 via in vitro reconstitution. Superresolution live imaging reveals STING becomes punctate an...
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作者：Liu, Pengfei; Jin, Ziliang; Gong, Zheng; Li, Long; Wang, Kang; Zeng, Xiandi; Liu, Jing; Song, Dongsheng; Du, Haifeng; Zhu, Kelei; Yan, Chuanxin; Li, Jinhua; Zhang, Keke; Williams, Wyn; Hirt, Ann M.
作者单位：Macau University of Science and Technology; Macau University of Science and Technology; Nanjing University; Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS; Anhui University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Geology & Geophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Edinburgh; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：On the lunar surface alpha-Fe and Fe-Ni alloys are widespread and the dominant carriers of the lunar remanent magnetization. Metallic gamma-Fe, however, is stable only at high temperatures and has not been documented in lunar samples. Here we report the identification of ambient stable gamma-Fe preserved as nanometer-scale particles in Chang'e-6 impact glass fragments from the South Pole-Aitken Basin. Electron holography analyses reveal that these gamma-Fe particles have a magnetic vortex doma...
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作者：O'Neill, Mary Michael; Rodell, Matthew; Loomis, Bryant D.
摘要：Human activities have directly altered the water cycle through water management, aquifer pumping, agricultural irrigation, and land use change. Although satellite gravimetry has transformed global hydrological research, its coarse resolution limits attribution of freshwater change to human activities at many management-relevant scales. Here we assessed global terrestrial water storage (TWS) trends from April 2002 to November 2025 using stacked regression of Level-1B intersatellite ranging data...
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作者：Mizoguchi, Rakuto; Toda, Yasuka; Nagae, Mana; Yoshida, Takashi; Matsuura, Hiroaki; Hirata, Kunio; Lam, Vi Toan; Tran, Duy Phuoc; Kitao, Akio; Miyanoiri, Yohei; Hosotani, Maiko; Ashikawa, Yuji; Ito, Chiaki; Tsutsumi, Naotaka; Yasui, Norihisa; Ishimaru, Yoshiro; Yamashita, Atsuko
作者单位：Okayama University; Meiji University; University of Osaka; RIKEN; Institute of Science Tokyo
摘要：Taste receptor type 1 (TAS1R), which consists of sweet and umami receptors in humans, senses nutrients (such as sugars and amino acids) with substrate specificity that is often broad and varies among animals and subtypes. However, the structural basis for achieving diverse specificities remains largely elusive. Here, we present the crystal structure of the ligand-binding domain (LBD) of Tas1r1/Tas1r3 heterodimer from pufferfish, an ortholog of the human umami taste receptor. The overall struct...
