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作者：Khatun, Nurjahan; Khoury, Joe F.; Nkele, Agnes C.; Wang, Lingyu; Zhang, Tieqiong; Paul, Partha P.; Okoli, Paul Chibuike; Shamim, Nabila; Pasquali, Matteo; Bagchi, Kushal
作者单位：Rice University; Rice University; Rice University; United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory; Rice University
摘要：Transitions between crystalline phases occur either through the nucleation and growth mechanism, a process that is slow and destructive, or through the diffusion-less and order preserving Martensitic route. We demonstrate here that for canonical discotic organic semiconductor HAT6, the transition between the liquid crystalline columnar hexagonal phase (Col(H)) and the crystalline solid can occur through a mechanism that exhibits the hallmarks of Martensitic transformations: orientational corre...
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作者：Araujo, Gui; Thomas, Torsten; Webster, Nicole S.; Montoya, Jose M.; Lurgi, Miguel
作者单位：Swansea University; Centre National de la Recherche Scientifique (CNRS); University of New South Wales Sydney
摘要：Host-associated microbiomes often display host specificity and heritability, yet the evolutionary processes under which such structured communities first emerge are still unclear. In particular, the conditions by which intergenerational (i.e., vertical) transmission of microbes can evolve and generate host-specific microbiomes are still unresolved. Here, we present an eco-evolutionary theory of microbiome assembly under minimal assumptions of microbial dynamics (i.e., neutrally driven by envir...
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作者：Clausius, Ella; Edgar, Graham J.; Mellin, Camille; Phillips, Genevieve A. C.; Bates, Amanda E.; Benedetti-Cecchi, Lisandro; Brown, Christopher J.; Cinner, Joshua E.; Costello, Mark John; Sanabria-Fernandez, Jose A.; Gill, David A.; Hautecoeur, Cyril; Heather, Freddie J.; Lazzari, Natali; Lefcheck, Jonathan S.; Maire, Eva; Mouillot, David; Schuster, Jasmin M.; Schmid, Joanna K.; Stuart-Smith, Rick D.
作者单位：University of Tasmania; University of Tasmania; University of Victoria; University of Pisa; CoNISMa; University of Sydney; Nord University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); James Cook University; Duke University; Universite de Montpellier; Lancaster University; Simon Fraser University
摘要：The Convention on Biological Diversity's ambitious target to effectively conserve 30% of the world's oceans in protected areas by 2030 risks being undermined by a primary focus on total area protected rather than realized conservation outcomes. Area-based assessments can overstate success because few marine protected areas (MPAs) possess strong restrictions and high compliance. Here, we estimate the extent that conservation outcomes are realized across the global MPA network for shallow reefs ...
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作者：Jang, Hyo-Ju; Park, Euijung; Jung, Hyun Jun; Kwon, Tae-Hwan
作者单位：Kyungpook National University (KNU); Kyungpook National University (KNU); Kyungpook National University (KNU); Kyungpook National University (KNU); Kyungpook National University Hospital (KNUH); Johns Hopkins University; Johns Hopkins Medicine
摘要：Arginine vasopressin maintains water homeostasis by regulating epithelial water permeability through complex transcriptional mechanisms in kidney collecting duct cells. Although CTNNB1 (beta-catenin) functions as a transcriptional coregulator in vasopressin-responsive gene transcription, its role remains poorly understood. To identify CTNNB1-dependent components mediating the vasopressin-responsive transcription, we profiled transcriptomic changes following Ctnnb1 knockdown in mouse kidney col...
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作者：Bratu, Ana-Maria; Laplaud, Valentin; Garcia, Antoine; Josserand, Christophe; Drevensek, Stephanie; Duprat, Camille; Boudaoud, Arezki
摘要：The impact of droplets on concave surfaces is poorly understood, although it is relevant to a mode of dispersal of reproductive units that has evolved independently in several species of plants and fungi. This mode of dispersal relies on splash-cups, specialized organs that use raindrops to disperse reproductive units away from the parent organism. We investigated the impact of droplets on conical cavities that mimic splash-cups. We observed the formation of two types of jets, lateral and upwa...
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作者：Basargin, Andrian G.; Domokosa, Andras; Hennessey, Joseph J.; Aarrestad, Isak K.; Sambyal, Rohini; Khatib, Yara A.; Kruger, Johanna; Dunlap, Lee E.; Carter, Samuel J.; Rebek, Isabella A.; McKee, John L.; Schalk, Serena S.; Liu, Min; Fettinger, James C.; Gonzalez, Monica A.; Potluri, Abhay; Tantillo, Dean J.; Fiehn, Oliver; McCorvy, John D.; Olson, David E.
作者单位：University of California System; University of California Davis; University of California System; University of California Davis; Medical College of Wisconsin; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; Medical College of Wisconsin; California State University System; California State University Sacramento; University of California System; University of California Davis
摘要：Of the classic psychedelics, lysergic acid diethylamide (LSD) is perhaps the best-known, but its complex chemical architecture has limited synthetic investigations aimed at generating analogues with improved safety and efficacy profiles. Here, we systematically deconstruct the tetracyclic ergoline core of LSD to create 9 simplified ergoline analogues (i.e., ergologs) and evaluate them in pharmacological assays relevant to 5-HT2A, 5-HT2B, and 5-HT2C receptor function. Our work revealed the key ...
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作者：Brahmana, Ferio; Hopper, Corbin; Lee, Woojeong; Cho, Kwang-Hyun
摘要：It is crucial to identify cues that induce cell fate transitions for applications ranging from cell therapy to drug discovery. Computational analysis of logical models of gene regulatory networks can identify such cues, which can then be used by control strategies to direct cell fate. However, current control strategies emphasize permanent interventions that cripple natural regulatory responses, undermining phenotypic plasticity and risking unexpected behavior. We illustrate how, conversely, s...
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作者：Xu, Max Wenqiang
摘要：Let f(n) be a Steinhaus random multiplicative function and let A subset of[1,N] be a finite set of integers. We show that convergence of |A|-1/2 & sum;n is an element of Af(n) to a standard complex normal distribution forces |A|=o(N). We prove that this zero-density condition is sharp: For most sets A of density rho, and hence for some such sets, a complex Gaussian limit holds whenever (1-rho)-1=o((loglogN)1/2). However, for positive density, the correct normalization is (1-rho)|A| rather than...
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作者：Daniel, Bence; Chen, Andy Y.; Sandor, Katalin; Zhang, Wenxi; Miao, Zhuang; Yost, Kathryn E.; Lareau, Caleb A.; Chang, Howard Y.; Satpathy, Ansuman T.
作者单位：National Institutes of Health (NIH) - USA; Stanford University; Stanford University; Stanford University; Stanford University
摘要：Three-dimensional (3D) genome conformation is central to gene expression regulation, yet our understanding of its contribution to rapid transcriptional responses, signal integration, and memory in immune cells is limited. Here, we study the molecular regulation of the inflammatory response in primary macrophages using integrated transcriptomic, epigenomic, and chromosome conformation data, including base pair-resolution Micro Capture-C. We demonstrate that interleukin-4 (IL-4) primes the infla...
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作者：Tian, Yuanyuan; Chi, Hanzhi; Tey, Wei Shian; Zhang, Zuoqi; Fan, Jingbo; Lim, Zheng Han; Ong, Adrian; Qi, Jerry; Zhou, Kun
摘要：Powder bed fusion (PBF)-printed fiber-reinforced composites often exhibit powder-recoating-induced anisotropy, resulting in direction-dependent mechanical behavior that limits reliability under multidirectional loading. Inspired by the surface-following alignment of enamel rods in tooth enamel, we develop a fabric architecture that integrates build-orientation-controlled fiber alignment with a staggered interlocking topology of cubic unit cells. By optimizing build orientation and leveraging i...
