38期

最新文章

• Expanding frameworks: Integrating vulnerability, exposure, and critical infrastructure to assess pluvial flood risks in New York City AI翻译
  作者：Herreros-Cantis, Pablo; McPhearson, Timon; Rosenzweig, Bernice R.; Madajewicz, Malgosia; Cook, Elizabeth M.; Olivotto, Veronica; Dennis, Evan; Montalto, Franco A.; Cherrier, Jennifer
  摘要：Extreme precipitation events are increasing their frequency and intensity across the United States, posing growing risks to urban communities through pluvial flooding. Effective adaptation against pluvial flooding through structural and nonstructural measures requires understanding the spatial distribution of flood risks across urban populations and critical infrastructures. However, most flood risk assessments focus narrowly on the direct impacts of flooding and demographic exposures, overloo...
• Adenylate cyclase Mac1 functions as a cutin monomer receptor to drive appressorium development and infection in Magnaporthe oryzae AI翻译
  作者：Li, Hui; Li, Yan; Wang, Jing; Wang, Qing; Liu, Xiaohong; Wu, Minghua; An, Chunyue; Cai, Yingying; Huang, Pengyun; Zhu, Xueming; Yan, Jiongyi; Shi, Xuetao; Wang, Jiaoyu; Lin, Fu-Cheng; Lu, Jianping
  作者单位：Zhejiang University; Xianghu Laboratory; Zhejiang Academy of Agricultural Sciences; Zhejiang University; Linyi University
  摘要：The rice blast fungus Magnaporthe oryzae senses plant surface cues, such as cutin monomers, to initiate appressorium formation. Although cutin monomers are known to trigger the cAMP-protein kinase A signaling pathway, their fungal receptor has remained unknown. Here, we identify the adenylate cyclase Mac1 as a direct receptor for cutin monomers in M. oryzae. A 32-amino acid segment (residues 424 to 455) in Mac1's N terminus is specifically required for its binding to and activation by cutin mo...
• A lipid cue drives the subcellular localization of a self-inserting bacterial transmembrane protein AI翻译
  作者：Pande, Vani; Updegrove, Taylor B.; Anantharaman, Vivek; Bae, Ashley; Chen, Jiji; Aravind, L.; Ramamurthi, Kumaran S.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM); Division of Intramural Research (DIR); National Institutes of Health (NIH) - USA
  摘要：The correct subcellular localization of proteins is a critical step underlying myriad biological processes, but the cues that drive the specific localization of integral membrane proteins in bacteria remain largely undeciphered. During sporulation in Bacillus subtilis, a rod-shaped outer mother cell constructs an internal spherical forespore cell that eventually matures into the spore. The integral membrane protein ShfA is made in the mother cell cytosol and localizes to the surface of the for...
• RHAMM drives formation of polyploid cancer cells and confers resistance to ER-targeted therapy in breast cancer AI翻译
  作者：Wu, Shiyi; Chen, Si; Liu, Bohan; Liu, Yuting; Yang, Siyue; Hu, Jiajie; He, Yiqing; Liu, Qinqing; Liu, Yiwen; Du, Yan; Zhang, Guoliang; Guo, Qian; Gao, Feng; Tang, Fen; Xu, Yongming; Yang, Cuixia
  作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University
  摘要：Endocrine resistance in ER+ breast cancer remains a major clinical challenge. Here, we identify RHAMM as a key driver of resistance by orchestrating polyploid cancer cell (PCC) formation. Single-cell transcriptomics uncovered a G2/M-enriched, RHAMM+ subpopulation in endocrine-resistant tumors. Mechanistically, RHAMM binds Septin9/10 to promote aberrant cytoskeleton polymerization, activating YAP independent of Hippo signaling, which induces cytokinesis failure and facilitates PCC generation. C...
• Soft photonic hydrogel interfaces for autonomous and dynamic thermoregulation AI翻译
  作者：Ye, Qin; Huang, Yimou; Guo, Shuai; Wang, Jiepin; Liang, Kaiqi; Shin, Chan Jae; Yu, Zhen; Guo, Xingkui; Zhao, Mang; Lu, Haojie; Zhang, Yaoxin; Li, Qing; Chen, Zhuo; Yan, Hongjie; Yu, Zhong-Zhen; Chen, Meijie; Bai, Wubin; Tan, Swee Ching
  作者单位：Central South University; National University of Singapore; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Beijing University of Chemical Technology; Shanghai Jiao Tong University
  摘要：Adaptive passive cooling offers an energy-efficient approach to thermal management by dynamically responding to changes in solar irradiation, temperature, and humidity without external power input. However, existing adaptive thermoregulation materials remain limited by structural-mechanical mismatches in rigid multilayer architectures and weak coupling among optical, sorption, and mechanical functions. Here, we report a soft photonic hydrogel interface whose adaptive thermal regulation perform...
• Visible light leaves evaporation and interfacial structure of neat water unchanged at the air-water interface AI翻译
  作者：Chen, Yucong; Shirley, Joseph C.; Ng, Zi Xuan; Wang, Yongkang; Nagata, Yuki; Hazrah, Arsh S.; Bonn, Mischa
  摘要：Visible light-induced photomolecular enhancement of water evaporation has been proposed as a fundamentally new mode of light-matter interaction at aqueous interfaces, with far-reaching implications for climate processes and light-driven water technologies. Yet, the response of neat interfacial water to visible photons has not been directly quantified at both macroscopic and molecular scales. Here, we combine high-precision confocal displacement measurements with a surface-specific vibrational ...
• Local delivery of interferon restores antigen presentation and sensitizes medulloblastoma to T cell killing AI翻译
  作者：Eisemann, Tanja; Chambers, Kendall R.; Masihi, Meher Beigi; Tzaridis, Theophilos; Sajina, G. C.; Pister, Veronika; Youm, Isaac; Dutta, Aditi; Wenzel, Alexander T.; Chin, Koei; Xu, Zhenhua; Pei, Yanxin; Pomeroy, Scott L.; Mesirov, Jill P.; Fraenkel, Ernest; Bagchi, Anindya; Chavez, Lukas; Wechsler-Reya, Robert J.
  摘要：Medulloblastomas are considered immunologically cold and refractory to immunotherapy. One factor contributing to their low immunogenicity is impaired antigen presentation, which allows tumor cells to evade cytotoxic T cells. Using a syngeneic mouse model of medulloblastoma, we demonstrate that despite low expression of MHC class I on tumor cells, depletion of CD8(+) T cells accelerates tumor growth, whereas adoptive transfer of tumor-reactive CD8(+) T cells prolongs survival. These antitumor e...
• FAP53 facilitates formation of microtubule doublets AI翻译
  作者：Li, Ming; Chen, Guanghan; Chen, Zhe; Guo, Zhengyang; Wang, Zi; Chai, Yongping; Li, Wei; Ou, Guangshuo
  作者单位：Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University
  摘要：The formation of microtubule doublets (MTDs) is a foundational step in cilia biogenesis, yet how B-tubule nucleation is initiated at the molecular level remains elusive. Here, we identify FAP53 as a factor that facilitates B-tubule assembly in a scaffold-dependent manner. In vitro reconstitution demonstrated that recombinant FAP53 enhances MTD formation in the presence of preassembled microtubule scaffolds, but is insufficient to drive de novo assembly from free tubulin alone. In cultured HeLa...
• TRPV4 mediates low-humidity responses in epidermal keratinocytes AI翻译
  作者：Tanaka, Manami; Chikuma, Shunsuke; Hara-Chikuma, Mariko
  作者单位：Keio University; National Tsing Hua University
  摘要：Environmental humidity is a key determinant of organismal physiology and homeostasis. Although the genetic basis of humidity-driven responses is well established in invertebrates, the molecular and genetic mechanisms by which mammals respond to low humidity remain unclear. Here, using reconstructed 3D epidermal equivalents and a mouse model, we identify transient receptor potential vanilloid 4 (TRPV4) as an important mediator of low-humidity-induced signaling and transcriptional responses in e...
• A further modification of the elastic field of an edge dislocation is incorrect AI翻译
  作者：Trinkle, Dallas R.