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作者：Irfan, Umair
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作者：Pickett, Steward T. A.; McPhearson, Timon
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作者：Singh, Aayushi; Burns, Daniel; Sedinkin, Sergey L.; Das, Sayan; Potoyan, Davit A.; Venditti, Vincenzo
作者单位：Iowa State University; Iowa State University
摘要：Understanding how phosphoenolpyruvate (PEP) binding induces the large open-to-closed conformational transition of bacterial Enzyme I (EI) has remained a long-standing problem in structural biology. In EI, PEP binds the C-terminal EIC domain, yet catalysis requires docking of the distant N-terminal EIN domain, which carries the active-site H189 residue, onto EIC. How this local binding event is coupled to global domain rearrangement has been unclear. Here, we combine experimental Chemical Shift...
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作者：Zhu, Yingtong; Sulaeman, Johan; Carrasco, Luis Roman
摘要：Deforestation is a fundamental upstream risk to global sustainability, affecting all three pillars of credible Environmental, Social, and Governance (ESG) assessments, which are crucial sources of information facilitating sustainable investment decisions. However, the efficacy of major commercial ESG assessment tools in capturing corporate deforestation exposure remains unknown. We examine the relationship between corporate ESG ratings from five major ESG rating providers and two geospatially ...
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作者：Vopalensky, Pavel; Nesuta, Ondrej; Mititelu, Maria-Bianca; Skriba, Anton; Spampinato, Ambra; Viktorinova, Klara; Buchova, Zuzana; Brezinova, Jana; Reyes-Gutierrez, Paul E.; Luksan, Ondrej; Cahova, Hana
作者单位：Czech Academy of Sciences; Institute of Organic Chemistry & Biochemistry of the Czech Academy of Sciences; Charles University Prague
摘要：It was long believed that the eukaryotic RNA was primarily capped with 7-methylguanosine (m(7)G). However, the expanding field of noncanonical RNA caps recently revealed the presence of other structures (nicotinamide adenine dinucleotide, flavin adenine dinucleotide, dinucleoside polyphosphates) at the 5 ' end of various mRNAs and noncoding RNAs. We report here on the detection and quantification of a new type of RNA cap-diadenosine diphosphate (Ap(2)A) and adenosine guanosine diphosphate (Ap(...
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作者：Xie, Yuanyuan; Du, Lifeng; Chen, Zhijuan; Li, Xiaoyi; Jiang, Danhua; Zhao, Fangqing; Li, Zicong
作者单位：Shandong University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Zoology, CAS; Shanxi Normal University; National University of Singapore
摘要：Histone modifications and cotranscriptional processing play fundamental roles in regulating eukaryotic gene transcription. Active histone modifications and efficient cotranscriptional mRNA processing act in concert to promote transcription, whereas repressive histone marks are normally depleted from active genes. However, the localization of repressive histone marks at transcribing genes and the regulatory mechanism in mRNA transcription are largely unclear. Here, we show that in Arabidopsis t...
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作者：Post, Eric
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作者：Tripathi, Sunil Jamuna; Chakraborty, Suwarna; Wood, Neil B.; Hoopes, Dillon; Barker, Sarah; Vazquez-Rosa, Edwin; An, Jiu; Ma, Chunxuan; Hou, Yuan; Sharma, Sudarshana M.; Cheng, Feixiong; Thomas, Bobby; Orsburn, Benjamin C.; Fried, Stephen D.; Snyder, Solomon H.; Pieper, Andrew A.; Paul, Bindu D.
作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; Johns Hopkins University; Cleveland Clinic Foundation; University System of Ohio; Cleveland Clinic Foundation; Case Western Reserve University; University System of Ohio; Case Western Reserve University; Medical University of South Carolina; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine
摘要：Dysregulated dopamine (DA) signaling and redox homeostasis contributes to multiple neuropsychiatric and neurodegenerative disorders. Polymorphisms that influence the activity of catechol-O-methyltransferase (COMT), an enzyme critical for degrading DA in the dorsolateral prefrontal cortex, have been implicated in behavioral and neuropsychiatric alterations associated with schizophrenia (SCZ). Adverse neuropsychiatric effects have also been reported in Parkinson's disease (PD) patients administe...
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作者：York, Nicholas J.; Zhang, Xuekai; Booker, Squire J.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Pennsylvania; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Pennsylvania; Pennsylvania Medicine
摘要：The radical S-adenosylmethionine (SAM) superfamily comprises more than 800,000 enzymes that use [Fe4S4] clusters to initiate radical chemistry that mediates an exceptionally broad range of chemical transformations. Within this superfamily, cobalamin (Cbl)-dependent radical SAM enzymes constitute a major subclass predominantly associated with methylation reactions. However, several notable members catalyze nonmethylase reactions, for which the mechanistic role of Cbl is poorly understood. Bacte...
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作者：Grove, J. Morgan; Pickett, Steward T. A.
摘要：Segregation, or social-economic inequity across space, is a widespread phenomenon. What can ecology, with its fundamental concern for spatial heterogeneity, contribute conceptually and practically to issues of segregation? And what can urban ecology learn? The relationships of four established perspectives about environmental inequity and injustice can help answer these questions. All the perspectives acknowledge the social construction of race and similar rankings. Patterns and drivers of seg...
