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作者：Sebastian, John; Jensen, Kaare H.
作者单位：Technical University of Denmark
摘要：Despite their ubiquity in Nature, spikes or stingers rarely exhibit sharp tips. Instead, a closer inspection of their roughly conical tips reveals a striking similarity in their profiles: They adhere to a power-law, z similar to rn, where n approximate to 2. This conformity persists across diverse spatial scales and materials. The mechanistic basis for this universality was recently attributed to evolutionary selection for ease of piercing [H. Quan et al., Proc. Natl. Acad. Sci. U.S.A. 121, e2...
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作者：Silber, Katy M.; Boyle, W. Alice
作者单位：Kansas State University; Western University (University of Western Ontario)
摘要：Precipitation influences animal physiology, behavior, and ecological interactions, therefore affecting demography. However, the nature and strength of those effects vary widely, have been attributed to mechanisms operating over different time scales, and may depend on species-level attributes. We conducted a global meta-analysis accounting for shared evolutionary history to a) understand the nature of relationships between precipitation and avian reproductive success and b) test alternative hy...
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作者：Ganguly, Abira; Zmuda, Hannah; Abello, Javier; Illy, Danielle; Walter, Christopher; Tsatskis, Yonit; Thanintorn, Nattapon; Zhang, Ying; Hakim, Bilal Ahmad; Hodzic, Didier; Stratman, Amber N.; Jurisicova, Andrea; Pathak, Amit; Mcneill, Helen
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum Research Institute; University of Toronto; University of Toronto
摘要：Nuclear Envelope Membrane Protein 1 (NEMP1) is crucial for metazoan fertility; loss of Nemp1 causes death of primordial oocytes that reside in the mechanically challenging ovarian cortex. Here, we show that softening the ovary rescues oocyte loss and restores substrates leads to death, while cells remain viable on soft substrates. We further show Mechanistically, Nemp1-depleted cells on stiff substrates or subjected to stretching exhibit reduced nuclear YAP localization, and expressing nuclear...
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作者：Wang, Weihao; Chen, Fangyi; Chen, Zhenghong; Sun, Yutong; Liu, Feng; Zhang, Shaodong
作者单位：Shanghai Jiao Tong University; Xi'an Jiaotong University
摘要：Racemic compounds, consisting of an equimolar mixture of enantiomers in crystalline form, are conventionally regarded as fully symmetric and are often dismissed as a trivial phenomenon due to their abundance-as they account for a substantial fraction (90 to 95%) of entries in structural databases. Here, we uncover the symmetry--breaking hierarchical organization within racemic compounds: single-handed molecules first self--assemble into homochiral domains, which then periodically self--organiz...
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作者：Araujo, Eduardo Correa; Carvalho, Luiz Max; Ganem, Fabiana; Vacaro, Lua Bida; Bastos, Leonardo S.; Freitas, Lais Picinini; Almeida, Iasmim Ferreira De; Bastos, Marcio; Alencar, Ramila; Bianchi, Lucas; Capellan, Raul; Chen, Xiang; Cruz, Oswaldo; Cunha, Americo; Das, Haridas K.; Fletcher, Chloe; Lana, Raquel Martins; Lowe, Rachel; Luhrsen, Daniela; Moirano, Giovenale; Moraga, Paula; Stolerman, Lucas M.; Valente, Fernanda; Codeco, Claudia Torres; Coelho, Flavio C.
作者单位：Getulio Vargas Foundation; Fundacao Oswaldo Cruz; Universitat Politecnica de Catalunya; Barcelona Supercomputer Center (BSC-CNS); King Abdullah University of Science & Technology; Universidade do Estado do Rio de Janeiro; Laboratorio Nacional de Computacao Cientifica (LNCC); Oklahoma State University System; Oklahoma State University - Stillwater; ICREA; Getulio Vargas Foundation
摘要：Forecast models are a key decision-support tool for public health authorities in managing epidemics, feeding into early warning systems, scenario evaluations, and an empirical basis for resource allocation. In Brazil, improving dengue forecasting became a priority in response to the unprecedented increase in cases, which surpassed the total of the previous decade and expanded to new regions. The Infodengue-Mosqlimate consortium launched the Infodengue-Mosqlimate Dengue Challenge 2024 (IMDC24),...
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作者：Boskovic, Pavle; Shalita, Rotem; Gao, Wenqing; Vernon, Hailey; Deng, Yu Lin; Colonna, Marco; Majzner, Robbie G.; Amit, Ido; Kipnis, Jonathan
作者单位：Washington University (WUSTL); Washington University (WUSTL); Weizmann Institute of Science; Hong Kong University of Science & Technology; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Dana-Farber Cancer Institute
摘要：Alzheimer's disease (AD) is the prevailing cause of age-associated dementia worldwide. Current standard of care relies on antibody-based immunotherapy. However, antibody-based approaches carry risks for patients, and their effects on cognition are marginal. Increasing evidence suggests that T cells contribute to AD onset and progression. Unlike the cytotoxic effects of CD8+ cells, CD4+ T cells capable of regulating inflammation show promise in reducing pathology and improving cognitive outcome...
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作者：Lebender, Leonard F.; Seidinger, Alexander; Matthey, Michaela; Dyck, Birte; Schlamm, Christian; Kaddoura, Abdullah; Hausherr, Maximilian; Eggers, Britta; Marcus, Katrin; Kostenis, Evi; Gieselmann, Volkmar; Adamzik, Michael; Klinke, Anna; Koos, Bjorn; Fleischmann, Bernd K.; Wenzel, Daniela
作者单位：University of Bonn; Ruhr University Bochum; Ruhr University Bochum; Ruhr University Bochum; Ruhr University Bochum; University of Bonn; University of Bonn
摘要：Pulmonary arterial hypertension (PAH) is a serious disorder, in which increased vascular tone is one of the critical hallmarks. Since beta arrestins (bArrs) have been shown to regulate smooth muscle tone in the airways, we investigated the function of bArr1 in the pulmonary vasculature. Here, we report that bArr1 is essential for maintaining normal pulmonary arterial tone. Specifically, pulmonary arteries from bArr1-/- mice exhibited reduced NO-dependent vasorelaxation due to impaired soluble ...
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作者：Li, Feng; Radhakrishnan, Abhijith; Gautam, Sudhanshu; Diaz, Gabriel; Sundaram, Ramalingam Venkat Kalyana; Coleman, Jeff; Zheng, Hong; Grushin, Kirill; Chavent, Matthieu; Rothman, James E.; Pincet, Frederic
作者单位：Yale University; Yale University; Universite de Toulouse (EPE); Centre National de la Recherche Scientifique (CNRS); Communaute d'universites et etablissements de Toulouse (Comue); Sorbonne Universite; Universite PSL; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Ecole Normale Superieure (ENS)
摘要：Munc13-1 is a key protein involved in priming synaptic vesicles for rapid release at the presynaptic plasma membrane. It was previously revealed that Munc13-1 cycles between at least two alternate conformations, an upright (open) molecular conformation organized as a trimer and a lateral (closed) conformation organized as a hexagon. Munc13 binds PI(4,5)P2, a plasma membrane phospholipid essential for vesicle docking and fusion. We report that Munc13 is recruited to PI(4,5)P2 domains induced by...
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作者：Maddu, Suryanarayana; Kelleher, Colm P.; Basaran, Mustafa; Muller-Reichert, Thomas; Shelley, Michael J.; Needleman, Daniel J.
作者单位：Simons Foundation; Flatiron Institute; Syracuse University; Harvard University; Technische Universitat Dresden; New York University
摘要：How thousands of microtubules (MTs) and molecular motors self-organize into spindles remains poorly understood. By combining static, nanometer-resolution, largescale electron tomography reconstructions and dynamic, optical-resolution, polarized light microscopy, we test an active liquid crystal continuum theory of mitotic spindles in human tissue culture cells. At micron length scales, probed by optical microscopy, the continuum theory accurately captures spindle morphology and fluctuation spe...
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作者：Hu, Yue; Gruen, Jeffrey R.; Zhang, Heping
作者单位：Yale University; Yale University
摘要：Depression is shaped by both genetic and environmental factors, but genome-wide interaction studies (GWIS) often lack power to detect complex gene-environment (G & times; E) interactions. We applied a forest-based machine learning approach to 38,018 UK Biobank (UKB) participants, examining interactions between 285,677 single-nucleotide polymorphisms (SNPs) and three trauma types (childhood, adult, and catastrophic trauma). While GWIS detected no significant interactions, we identified 8,225 po...
