2026

最新文章

• Partial reconstitution of the prophenoloxidase activation system in Anopheles gambiae AI翻译
  作者：Hou, Chunxiang; Wang, Yang; Jiang, Haobo
  作者单位：Oklahoma State University System; Oklahoma State University - Stillwater
  摘要：Melanization is a central insect immune response to wounding and microbial invasion. It is mediated by a system of serine proteases and their homologs, mostly members of the CLIP subfamily, and leads to prophenoloxidase (proPO) activation and PO-mediated production of cytotoxic compounds and melanin polymers that kill and sequester invading pathogens. In mosquitoes, melanotic encapsulation provides an effective defense against malaria parasites, yet the composition and organization of the unde...
• Simultaneous transformations of view and place coding across reference frames in the macaque brain AI翻译
  作者：Huang, Yan; Liu, Anran; Xu, Xiao; Du, Kechen; Mao, Dun
  作者单位：Chinese Academy of Sciences; Center for Excellence in Brain Science and Intelligence Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; ShanghaiTech University; Lin Gang Laboratory
  摘要：Vision enables primates to remotely map their environment using eye movements rather than physical locomotion. While view-related spatial coding is prevalent in the primate hippocampus, its origin and precise relationship to standard place coding remain largely unknown. Leveraging untethered neural recording, motion capture, and wireless eye tracking, we examined view and place coding along the parietal-retrosplenial-hippocampal pathway in macaque monkeys freely exploring an open arena. We ide...
• Polyunsaturated fatty acid-derived lipid mediator patterns determine viral pneumonia severity and risk for critical COVID-19 AI翻译
  作者：Papadaki, Maria; Pavlos, Eleftherios; Dubourdeau, Marc; Bailif, Vincent; Badirou, Kamal; Gely, Clemence A.; Galani, Ioanna-Evdokia; Papelis, Dimitris; Kamperi, Natalia; Triantafyllia, Vasiliki; Siouti, Eleni; Salagianni, Maria; Manioudaki, Maria; Paschalidis, Nikolaos; Vatsellas, Giannis; Koukaki, Evangelia; Rapti, Vasiliki; Thanos, Dimitris; Rovina, Nikoletta; Poulakou, Garyfallia; Cobat, Aurelie; Casanova, Jean-Laurent; Tamvakopoulos, Constantin; Andreakos, Evangelos
  作者单位：Academy of Athens; University of Crete; Academy of Athens; Academy of Athens; Academy of Athens; National & Kapodistrian University of Athens; National & Kapodistrian University of Athens; Rockefeller University; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; Howard Hughes Medical Institute
  摘要：Severe respiratory infections such as COVID-19 are characterized by excessive inflammation leading to the development of pneumonia and acute respiratory distress syndrome. Bioactive lipid mediators (LMs) derived from omega 6 and omega 3 polyunsaturated fatty acids are central to the regulation of inflammation, controlling both its initiation and resolution. Still, their role in viral infections remains underexplored. By employing a holistic approach involving the analysis of white blood cell t...
• Advancing AI negotiations: A large-scale autonomous negotiation competition AI翻译
  作者：Vaccaro, Michelle; Caosun, Michael; Ju, Harang; Aral, Sinan; Curhan, Jared R.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Johns Hopkins University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：We conducted an international AI negotiation competition in which participants designed and refined prompts for AI negotiation agents. We then facilitated over 180,000 negotiations between these agents across multiple scenarios with diverse characteristics and objectives. Our findings revealed that principles from human negotiation theory remain crucial even in AI-AI contexts. Surprisingly, warmth-a traditionally human relationship-building trait-was consistently associated with superior outco...
• Reply to Ritson-Williams et al. and Loya and van Woesik: Coral replacement research is vital due to uncertainty and unprecedented stress AI翻译
  作者：Camacho, Alejandro E.; Dana, David A.; Matz, Mikhail
  作者单位：University of California System; University of California Los Angeles; Northwestern University; University of Texas System; University of Texas Austin
• Multiplex gene editing enables the multibiofortification of essential vitamins and other health-promoting phytonutrients in tomato AI翻译
  作者：Hong, Yechun; Yu, Zongjun; Zhu, Wenbo; Sun, Jialei; Zhu, Zeyao; Wang, Zhen; Cao, Minjie; Lang, Zhaobo; Lyu, Yu-Xuan; Liu, Pengpeng; Zhu, Jian-Kang
  作者单位：Southern University of Science & Technology; Southern University of Science & Technology; Anhui Agricultural University; Macau University of Science and Technology
  摘要：Dietary deficiencies in essential micronutrients and other phytonutrients represent a global health and economic burden, contributing to hidden hunger and chronic diseases. While genome editing has been employed to improve individual nutritional traits in crops, multibiofortification through simultaneous modification of multiple distinct metabolic pathways is more challenging. Here, we designed a multiplex CRISPR-Cas strategy to edit five key genes in tomato: Sl7-DR2, SlGAD3, SlSGR1, SlGGP1, a...
• Illuminating proinflammatory myeloid cells with PET tracers targeting GPR84 AI翻译
  作者：Kalita, Mausam; Kuo, Renesmee C.; Straniero, Valentina; Reyes, Samantha T.; Pandrala, Mallesh; Lanzini, Alessia; Marsango, Sara; D'Moore, Desiree; Mahn, Piper; Setiadi, Andrew; Sundar, Mira; Mak, Spencer; Nagy, Sydney; Alam, Israt S.; Jain, Poorva; Inay, Grace; Malek, Rim; Brooks, Allen F.; Beinat, Corinne; Valoti, Ermanno; Scott, Peter J. H.; Milligan, Graeme; James, Michelle L.
  作者单位：Stanford University; Stanford Medicine; Stanford University; University of Milan; University of Glasgow; University of Michigan System; University of Michigan; Stanford University; Stanford Medicine
  摘要：Innate immunity mediated by myeloid cells defends against infection and injury, but when chronically activated, it drives tissue damage and neurodegeneration. Molecular imaging with positron emission tomography (PET) enables noninvasive, real-time monitoring of such processes in vivo. However, most current neuroinflammation PET tracers lack specificity for activated myeloid cells. G protein-coupled receptor 84 (GPR84) is a promising biomarker that is selectively upregulated on activated microg...
• ICMT supports BRAFV600E-driven tumor growth by membrane targeting of the CAAX protein INPP5E AI翻译
  作者：Yang, Xijie; Qiao, Xi; Schmidt, Sarah; Eklund, Ella A.; Ebner-Walter, Carolina; Ivarsson, Emil; Crespo, Michelle Ann; Kersemakers, Nadieh; Dzanan, Jozefina J.; Thorisson, Bjarni; Lundgren, Christine; Lim, Hooi Ching; Shkoukani, Sam; Tuksammel, Elin; Xu, Xiufeng; Sayin, Volkan I.; Martin-Fontecha, Mar; Ortega-Gutierrez, Silvia; Dalin, Martin; Bergo, Martin O.
  作者单位：Karolinska Institutet; University of Gothenburg; University of Gothenburg; University of Gothenburg; Complutense University of Madrid; Complutense University of Madrid; University of Gothenburg
  摘要：Isoprenylcysteine carboxyl methyltransferase (ICMT) catalyzes C-terminal methylation of prenylated CAAX proteins, a final processing step promoting membrane association and signaling. Although ICMT has been pursued to disrupt RAS membrane targeting, its role in BRAFV600E-driven cancers and critical substrates remains unclear. Here, genetic and pharmacologic (UCM-1336) ICMT inhibition suppressed proliferation and invasion in BRAFV600E-mutant melanoma cells and reduced tumor growth in xenografts...
• Coordinated stomatal, mesophyll, and biochemical functions in photosynthetic responses to heat and dryness AI翻译
  作者：Hu, Xingyu; Wong, Suan Chin; Farquhar, Graham D.
  作者单位：Tsinghua University; Australian National University
  摘要：The intrinsic link between temperature and leaf-to-air vapor pressure difference (Delta e) complicates isolation of their individual effects on photosynthesis. Consequently, how CO2 diffusion changes under heat and high evaporative demand, particularly through mesophyll conductance (g(m)) responses, remains poorly understood. The conditions under which biochemical colimitation occurs, meaning Rubisco carboxylation and RuBP regeneration capacities match, are also unclear. To advance understandi...
• The rising threats of global wildland-human interface revealed by a scale-adaptive approach AI翻译
  作者：Xia, Junnan; Kong, Xuesong; Jiao, Limin; Wei, Wei; Liu, Lingbo; Hu, Yuanchao; Wang, Zhen; Hong, Mengyao; Liu, Yaolin
  作者单位：Wuhan University; Jianghan University; Wuhan University; Harvard University; Guangdong University of Technology; Huazhong Agricultural University
  摘要：The Wildland-Human Interface (WHI), where human infrastructure and activities meet or intermingle with wildland vegetation, represents a critical zone of human-environmental conflict. Here, we present the first global map to explicitly differentiate the WHI into its Wildland-Urban Interface (WUI) and Wildland-Agriculture Interface (WAI) components between 2000 and 2020, using a scale-adaptive HEALpix Quadtree algorithm. We show that the global WHI covered 4.87% of terrestrial area in 2020, wit...