2026

最新文章

• Monkeypox virus protein OPG188 antagonizes cGAS-STING antiviral signaling pathway to mediate immune evasion AI翻译
  作者：Pan, Zhaoyi; Zhang, Shujuan; Geng, Xianbo; Wang, Na; Zhang, Lijiang; Wang, Luyao; Yin, Chunhong; Zhang, Huijiao; Liu, Shujun; Zhang, Ling; Fan, Jing; Xue, Guangjian; Li, Rui; Li, Tianle; Yu, Yating; Yao, Hangping; Jin, Changzhong; Wu, Nanping
  作者单位：Jinan Microecological Biomedicine Shandong Laboratory; Hangzhou Medical College; Shandong Center for Disease Prevention & Control; Shandong First Medical University & Shandong Academy of Medical Sciences; Zhejiang University; Collaborative Innovation Center for Diagnosis & Treatment of Infectious Diseases
  摘要：Innate immune evasion is critical for productive viral replication. Activation of the cGAS-STING antiviral signaling pathway and its downstream effector genes plays a pivotal role in restricting viral replication during early DNA virus infection. Through a comprehensive genomic screen of monkeypox virus (MPXV), we identified three viral genes, OPG147, OPG188, and OPG200, whose expression potently suppresses cGAS-STING pathway activation. Notably, the N-terminal domain of the Poxin protein enco...
• Moiré collapse and Luttinger liquids in twisted anisotropic homobilayers AI翻译
  作者：de Sousa, Duarte J. P.; Lee, Seungjun; Guinea, Francisco; Low, Tony
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
  摘要：We introduce twisted anisotropic homobilayers as a distinct class of moir & eacute; systems, characterized by a distinctive magic angle, theta M, where the moir & eacute; unit cell collapses. Unlike conventional studies of moir & eacute; materials, which primarily focus on small lattice misalignments, we demonstrate that this moir & eacute; collapse occurs at large twist angles in generic twisted anisotropic homobilayers. The collapse angle, theta M, is likely to give rise quasi-crystal behavi...
• Macrophage-glia interactions regulate immune damage to enteric neurons during West Nile virus infection AI翻译
  作者：Janova, Hana; Zhao, Fang R.; Akgul, Ali; Schatz, Meredith; Alligood, Daniel M.; Alvarado, David M.; Thackray, Larissa B.; Stappenbeck, Thaddeus S.; Diamond, Michael S.
  作者单位：Washington University (WUSTL); University of Texas System; University of Texas Health Science Center Houston; Washington University (WUSTL); Cleveland Clinic Foundation; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
  摘要：Functional gastrointestinal (GI) tract disorders affect a substantial proportion of the global population and are often preceded by intestinal infections that cause injury to enteric neurons and glia through unrestrained immune responses. However, the mechanisms that limit infection-induced inflammation and protect the enteric nervous system remain poorly understood. Here, we defined such neuron-glia-macrophage interactions after West Nile virus (WNV) infection; this model neurotropic virus ca...
• A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants AI翻译
  作者：Lavilla-Puerta, Mikel; He, Yuming; Piccinini, Luca; Di Paco, Lorenzo; Papachristodoulou, Antonis; Licausi, Francesco; Giuntoli, Beatrice
  作者单位：Scuola Superiore Sant'Anna; University of Oxford; University of Oxford; University of Pisa
  摘要：Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, when flooded. In vascular plants, transcriptional adaptive responses to hypoxia are rapidly mounted by Ethylene Response Factors VII (ERFVIIs), regulated by Plant Cysteine Oxidases (PCOs) through the cysteine branch of the N-degron pathway (Cys-NDP) for oxygen sensing. However, this relatively simple regulatory circuit, consisting of both constituti...
• Ambient ammonia synthesis from air via tandem water microdroplets-driven oxidation and pulsed photoelectrochemical reduction AI翻译
  作者：Li, Kejian; Dong, Wan Jae; Shen, Rui; Ye, Zhengwei; Zhang, Bingxing; Pan, Yuyang; Xia, Deming; Wang, Chunhua; Francisco, Joseph S.; Mi, Zetian
  作者单位：University of Michigan System; University of Michigan; Korea University; Korea Institute of Science & Technology (KIST); University of Pennsylvania
  摘要：Artificial N2 reduction offers a sustainable approach to green NH3 synthesis, but the practical implementation is challenged by N2 activation and competing hydrogen evolution. Photoelectrochemical nitrate and nitrite (NOx-, x = 2 and 3) reduction with favorable thermodynamics represents a promising alternative for NH3 production, provided that NOx-can be supplied from the atmosphere. Here, through leveraging water microdroplet chemistry and dynamic photoelectrode-electrolyte interface engineer...
• Modulation of electronic structure via dual moire patterns in twisted 1T-TaSe2 AI翻译
  作者：Liu, Yonghao; Zheng, Yuan; Yang, Kun; Zhang, Wenhao; Wu, Zongxiu; Gao, Jingjing; Luo, Xuan; Sun, Yuping; Zhang, Jin; Yin, Yi
  作者单位：Zhejiang University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; National Center for Nanoscience & Technology, CAS; Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS; Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS; Collaborative Innovation Center of Advanced Microstructures (CICAM); Nanjing University
  摘要：We investigate a twisted bilayer of 1T-TaSe2 (twist angle < 4(degrees)) using scanning tunneling microscopy and spectroscopy, revealing that the coexisting twisted atomic lattice and charge density wave (CDW) superlattice generate a dual moire structure with distinct electronic modulation effects: The topographic moire pattern stems from atomic lattice twisting modulating CDW intensity, while the twisted CDW superlattice drives a continuous insulator-to-metal transition, as evidenced by electr...
• Quantum-inspired entanglement between collaborating brains during human memory encoding AI翻译
  作者：Yang, Xue; Jiang, Yi; Zhou, Qianxiang; Pei, Kuan; Guo, Chunyan; Zhang, Peng
  作者单位：Capital Normal University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Psychology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Beihang University; Beihang University; Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：The extent to which two brains align during information processing is thought to be central to collaborative memory encoding; however, the neural mechanisms that support such interpersonal alignment remain elusive. Traditional interbrain synchrony models based on phase-alignment metrics fail to distinguish true interbrain connectivity from spurious synchrony driven by shared stimulus processing. Here, we introduce a quantum-inspired framework to capture the connectivity between two collaborati...
• Viral mimicry may help explain immunogenic cell death AI翻译
  作者：Levine, Matthew S.; Li, Jiexi; Ehrlich, Lauren I. R.; Depinho, Ronald A.; Iverson, Brent; Sessler, Jonathan L.
  作者单位：University of Texas System; UTMD Anderson Cancer Center; University of Texas System; University of Texas Austin
  摘要：Viral mimicry may be an underappreciated contributor to chemotherapeutic potency in animal models and patients. This hypothesis is based on studies of a bis-Au(I)-NHC complex that was found to generate a strong anti-tumor immune response in vivo in two different challenge studies using an iKAP colorectal cancer mouse model. RNA profiling of treated cells revealed the stimulation of genes that overlap with those upregulated during a viral infection. The bis-Au(I)-NHC complex generates reactive ...
• Extended local anesthesia enabled by flavonoid permeation enhancers AI翻译
  作者：Han, Yiyuan; Torre, Matthew; Ma, Xiaojing; Xue, Tianrui; Wang, Yuan; Jo, Sooyeon; Fujita, Akie; Bean, Bruce P.; Kohane, Daniel S.
  作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Baylor College of Medicine; Harvard University; Harvard Medical School
  摘要：Site 1 sodium channel blockers (S1SCBs), such as tetrodotoxin (TTX) and neosaxitoxin, are ultrapotent local anesthetics with low tissue toxicity. Their duration of action is relatively brief, but increasing the dose can lead to systemic toxicity. Here, we report that selected flavonoids-puerarin (PUE), naringenin, and kaempferol-prolong nerve block from S1SCBs 4-to 25-fold. Using both tympanic membrane (TM) permeation and sciatic nerve fluorescence distribution models, we demonstrate the flavo...
• Direct optical observation of solid electrolyte interphase formation dynamics in lithium- ion batteries AI翻译
  作者：Li, Wenlong; Sun, Tianxiao; Shah, Sameep Rajubhai; Ju, Zhengyu; Zhou, Jigang; Zhao, Kejie; Yu, Guihua; Liu, Yijin
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; Purdue University System; Purdue University; Purdue University in Indianapolis; General Motors
  摘要：Lithium-ion battery formation is a pivotal step that dictates performance, longevity, and manufacturing safety. At the core of this process is the formation and evolution of the solid electrolyte interphase (SEI), whose nanoscale thickness, high environmental sensitivity, and dynamic behavior have long hindered direct characterization. Here, we exploit the SEI-induced refractive index matching effect and utilize operando optical microscopy to directly visualize SEI growth in real time. Our obs...