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作者：Hirth, John P.; Wang, Jian
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作者：Ravindran, Sandeep
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作者：Friedman, Jeffrey M.
作者单位：Rockefeller University
摘要：In an extraordinary convergence, Emmanuel Mignot and Masashi Yanagisawa employed two entirely different approaches to establish the pathogenesis of narcolepsy, a devastating sleep disorder associated with overwhelming sleep attacks, cataplexy, episodes with sudden loss of muscle tone, and hallucinations resulting from dreaming while awake. Yanagisawa purified brain ligands for orphan G protein-coupled receptors identifying a peptide, orexin, and then used reverse genetics to show that a knocko...
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作者：Jiang, Qingyang; Xu, Ruiquan; Lin, Zhixin; Sun, Chenyu; Ye, Feidi; Ye, Yanyan; Lin, Duoming; Li, Zhen; Mai, Jingwen; Lin, Zhihong; Qu, Jiuxin; Deng, Xiaoyan; Ge, Chenchen; Wang, Dou
作者单位：Guangzhou Medical University; Shenzhen Technology University
摘要：CRISPR-based diagnostics (CRISPR-Dx) integrated with isothermal nucleic acid amplification have emerged as a promising strategy for point-of-care molecular testing. Their practical deployment, however, remains constrained by workflow-related limitations. Conventional two-step formats are laborious and highly susceptible to aerosol contamination during amplicon transfer, whereas simplified one-pot formats often suffer from reduced sensitivity because amplification and CRISPR-mediated cleavage c...
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作者：Li, Linjie; Nguyen, Linh; Qu, Hao; Wu, Qile; Gao, Pengyue; Li, Dedong; Li, Xinyu; Liu, Xueyuan; Jiang, Qiuyao; Liu, Kefang; Wong, Catherine C. L.; Gao, George Fu
作者单位：Chinese Academy of Sciences; Institute of Microbiology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Liaoning University; Shandong University; Shandong First Medical University & Shandong Academy of Medical Sciences; Beijing Life Science Academy; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College Hospital; Tsinghua University
摘要：SARS-CoV-2 continues to evolve. The subvariant BA.3.2 (Cicada), a derivative of the Omicron BA.3 subtype first detected in late 2024, harbors multiple spike protein mutations, ORF7 and ORF8 deletions, and has recently evolved sublineages (BA.3.2.1 and BA.3.2.2), rendering it a critical target for epidemiological surveillance. The BA.3.2.2 sublineage, represented by RE.2.2, shows a marked upward trend in late 2025. Using surface plasmon resonance, we found that RE.2.2's spike (S) protein recept...
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作者：Orpella, Joan; Mantegna, Francesco; Oderbolz, Chantal; Assaneo, M. Florencia; Poeppel, David
作者单位：Georgetown University; New York University; University of Oxford; Universidad Nacional Autonoma de Mexico; New York University
摘要：Inner speaking-the deliberate generation of speech through covert production mechanisms-is a common human experience. Current accounts propose that it engages sensorimotor processes similar to those underlying overt speech. Here, we asked whether motor and auditory representations during inner speaking maintain the granularity and temporal structure observed in overt speech. Using magnetoencephalography and time-resolved decoding, we examined neural dynamics across two experiments. Participant...
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作者：Pao, William
摘要：The 2026 Lasker similar to DeBakey Clinical Medical Research Award has been awarded to Kunihiro Hattori, Takehisa Kitazawa, and Tomoyuki Igawa (Chugai Pharmaceuticals, Tokyo, Japan) for invention of a bispecific antibody that joins blood clotting Factors IXa (FIXa) and X (FX), restoring deficient Factor VIII (FVIII) activity in patients with hemophilia A and preventing severe bleeding in this hereditary disorder. Starting from the 1960s, types of FVIII-replacement therapy remarkably improved o...
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作者：Sun, Jennifer M.; Sunderland, Elsie M.
作者单位：Harvard University
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作者：Cheng, Fei-Fei; Mou, Hao; Liu, Zhenyu; Zhang, Chang-Jun; Zhuang, You-Yuan; Wu, Zhen; Wen, Xin-Ran; Xue, Angli; Zhang, Xiao; Yang, Jian; Jin, Zi-Bing
作者单位：Westlake University; Capital Medical University; Wenzhou Medical University; University of Queensland; Garvan Institute of Medical Research; University of New South Wales Sydney; Westlake Laboratory
摘要：Age-related macular degeneration (AMD) is a leading cause of irreversible visual impairment in the aging population globally. Although genome-wide association studies (GWAS) have identified many AMD susceptibility loci, the genes and mechanisms underlying many of these associations remain unresolved. Here, we integrated expression quantitative trait locus (eQTL) data with AMD GWAS to prioritize nine putative genes. Through in vivo screening in zebrafish, we demonstrated that the downregulation...
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作者：Davydova, Tatiana; Marin Marin, Lidon; Cherednichenko, Anastasia; Fengler, Alexander; Adrian Ventura, Jesus; Palomar Garcia, Maria de los Angeles; Vives, Marc-Lluis; Costumero, Victor
作者单位：Universitat Jaume I; Brown University; University of Zaragoza; Leiden University; Leiden University - Excl LUMC
摘要：A successful strategy to down-regulate emotions is to simply label them (e.g., saying I'm sad when feeling sad). It however remains unresolved which mechanism is responsible for the efficacy of this approach known as affect labeling. Here, we constrain the proposed mechanisms of affect labeling by testing the scope of affect labeling in a new population previously neglected: bilinguals. Specifically, we examined two bilingual groups (Spanish-English, Spanish-Catalan) that varied in language do...
