2026

最新文章

• Lifestyles of Gypsy-family transposons shape their regulatory mechanisms AI翻译
  作者：Papameletiou, Anna-Maria; Nicholson, Benjamin Czech; Bornelov, Susanne; Hannon, Gregory J.
  作者单位：Cancer Research UK; CRUK Cambridge Institute; University of Cambridge; University of Cambridge
  摘要：Transposable elements (TEs) are a highly diverse group of selfish genomic elements, prevalent across the tree of life, whose uncontrolled propagation poses a threat to genome stability. Recent studies have explored the evolution of Drosophila melanogaster TEs, their coevolution with the host genome, and mechanisms that regulate their activity. However, little is known about their cross-species evolutionary patterns. Long terminal repeat (LTR) retrotransposons are the most active group of TEs i...
• An Octopus probe for high-performance >1,300 nm NIR-II fluorescence molecular imaging of cancer (vol 123, e2534014123, 2026) AI翻译
  作者：Peng, Zhennan; Liu, Haoran; Wang, Huaxi; Long, Runying; Yang, Qin; Lu, Zigang; Xu, Wenjun; Yin, Zhiwei; Zhang, Liming; Zhang, Feiran; Tian, Xiaodong; Ji, Xianglin; Jiang, Zijian; Chen, Yi; Lu, Haonan; Dai, Hongjie
• Strong human fingerprint on low snowpack amid increasing volatility AI翻译
  作者：Swain, Daniel L.
• Film-rupture actuated pump-free capillary enrichment for near-source airborne sampling AI翻译
  作者：Zhang, Chengqi; Liu, Shijie; Shen, Tao; Yu, Cunlong; Chu, Fuqiang; Jiang, Lei; Dong, Zhichao
  作者单位：Chinese Academy of Sciences; Technical Institute of Physics & Chemistry, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Beihang University; University of Science & Technology Beijing
  摘要：With the persistent threats from severe respiratory diseases and airborne pollutants, billions of people worldwide lack timely access to essential diagnostic services, particularly in low-resource regions where laboratory infrastructure is scarce. Conventional pump-suction airborne samplers face challenges including cost, power dependency, and unavoidable analyte loss in complex systems. Here, we demonstrate a film-rupture actuated capillary enrichment (FACE) airborne sampler that replaces ext...
• A lettuce receptor-like kinase recognizes the highly conserved heptapeptide motif within microbial Nep1-like proteins AI翻译
  作者：Banales, Inigo; Mehrem, Sarah L.; Almeida Landman, Samara; Alderkamp, Marrit; Pijfers, Max; Baijens, Stan; von Bredow, Alix; Schutte, Peter; Prevoo, Sander; van Asselt, Gijs; Sagayaradj, Sagayamary; Snoek, Basten; Michelmore, Richard; Lapin, Dmitry; van den Ackerveken, Guido
  作者单位：Utrecht University; Utrecht University; University of California System; University of California Davis; University of California System; University of California Davis
  摘要：Plants rely on cell surface immune receptors to detect microbial patterns and initiate effective defense responses. Although the Asteraceae family is one of the largest and economically important plant groups, little information is available about its pattern-triggered immunity signaling. Cultivated lettuce (Lactuca sativa L.) recognizes a 24-amino acid peptide (nlp24) from necrosis- and ethylene-inducing peptide 1 (Nep1)-like proteins (NLPs) found in bacteria, fungi, and oomycetes. Here, we p...
• Energy prioritization and neurometabolic scaling in a social insect brain AI翻译
  作者：Coto, Zach N.; Ye, Dajia; Arganda, Sara; Harrison, Jon F.; Traniello, James F. A.
  作者单位：Boston University; Stanford University; Universidad Rey Juan Carlos; Universidad Rey Juan Carlos; Arizona State University; Arizona State University-Tempe
  摘要：Brains are metabolically costly and due to their high energetic demands may receive priority under conditions of reduced energy availability. Such preferential energy allocation to the brain has been described for humans and other mammals, but previous studies have not directly quantified brain metabolic rate or simultaneously considered whole-body metabolism. We recorded brain metabolic rate ex vivo, brain mass, body mass, and whole-body metabolic rate in workers of the ant Tetramorium immigr...
• Antibiotic tolerance coupled with limited benefit from drainage: Clinical challenges in Klebsiella pneumoniae liver abscess AI翻译
  作者：Gong, Zibo; Guo, Yawen; Liu, Xiwen; Wang, Zhe; Li, Guofei; Chang, Zhihui
• An interdependent Cbf1-CCAN interaction stabilizes the budding yeast kinetochore AI翻译
  作者：Hedouin, Sabrine; Hu, Changkun; Biggins, Sue
  作者单位：Fred Hutchinson Cancer Center
  摘要：Chromosome segregation requires the proper assembly of kinetochores on centromeric DNA. The kinetochore is a complex multiprotein machine comprising more than 40 distinct proteins, but the functional roles of many components remain unclear. One such protein is the yeast transcription factor Cbf1, which directly binds to budding yeast centromeric DNA. Loss of Cbf1 significantly increases the rate of chromosome missegregation; however, its precise molecular mechanism of action is unknown. It was...
• Implicit biases change more slowly in larger cities AI翻译
  作者：Stier, Andrew J.
  作者单位：The Santa Fe Institute
  摘要：Implicit biases remain a contributor to discrimination despite widespread endorsement of equality. Although there has been a large-scale reduction in sexuality, race, and skin tone biases in the past two decades, there is a current shortage of quantitative theories that describe how and why biases change. Here, I present a theory of implicit bias change, which focuses on changes in exposure due to cultural information and how the speed of these changes varies geographically. This model makes c...
• Identification of novel functional sites in the Cav1.3 calcium channel α1-subunit using evolutionary modeling AI翻译
  作者：Tang, Xuechen; Hermenean, Horia C.; Yakimchyk, Alesia; Tuluc, Petronel; Ortner, Nadine J.; Liedl, Klaus R.
  作者单位：University of Innsbruck; University of Innsbruck; Medical University of Graz
  摘要：Voltage-gated calcium channels (VGCCs) regulate differentiation, function, and survival of excitable cells, and pathogenic variants cause diverse disorders. Most known disease-associated VGCC mutations affect well-characterized regions controlling voltage-dependent gating and channel kinetics, while many residues remain functionally unannotated. We developed an evolutionary model to predict the pathogenic potential of residues in the pore-forming Cav1.3 subunit, previously validated with de no...