2026

最新文章

• Whole-body central processing of lateral line inputs encodes fow direction relative to the center-of-mass AI翻译
  作者：Lunsford, Elias T.; Carbo-Tano, Martin; Wyart, Claire
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); University of Copenhagen
  摘要：From shifting visual scenes to tactile deformations and fluid motion, animals interpret patterns of sensory flow around their body to construct internal models and produce adaptive behavior. Understanding how such transformations are encoded in the brain remains incomplete. To tackle this question, we leverage the lateral line of larval zebrafish as a tractable system sensitive to fluid motion and used to steer navigation, feed, and avoid predators. By presenting stimuli of either direction to...
• Evolutionary pathways in epistatic mechanical networks AI翻译
  作者：Kardar, Mehran; Nagel, Sidney R.
  作者单位：University of Chicago
  摘要：An elastic spring network is an example of evolvable matter. It can be pruned to couple separated pairs of nodes so that when a strain is applied to one of them, the other responds either in-phase or out-of-phase. This produces two pruned networks, with incompatible functions, that are nearly identical but differ from each other by a set of mutations each of which removes or adds a single bond in the network. We generate ensembles of network pairs that differ by a fixed number, M, of discrete ...
• SARS-CoV-2 S assembly into virions facilitated by host ERM proteins AI翻译
  作者：Wang, Jiaming; Tai, Wanbo; Wang, Zhaoyang; Dai, Wenxin; Yang, Mingrui; Guo, Jiajian; He, Pengfei; Nan, Yanan; Li, Tianyu; Zhou, Shuqi; Cui, Dongxiao; Li, Yiqun; Ma, Cuiyan; Zhang, Yue; Li, Dongdong; Zhu, Zhengdan; Chu, Kexin; Wang, Dongdong; Yang, Songhui; Zhuang, Xinyu; Tian, Mingyao; Huang, Mingkang; Zhang, Xianwen; Cheng, Gong; Ma, Wenfu
  作者单位：Beijing University of Chinese Medicine; Tsinghua University; Shenzhen Bay Laboratory; Shenzhen Center for Disease Control & Prevention (SZCDC); Chinese Academy of Agricultural Sciences
  摘要：The host cell cytoskeleton plays a critical role in the SARS-CoV-2 life cycle, though the underlying mechanisms remain poorly understood. This study investigates the interaction between the SARS-CoV-2 spike (S) protein and the cytoskeleton-associated ezrin-radixin-moesin (ERM) proteins through biochemical and structural characterization. A previously unidentified ERM-binding motif on the SARS-CoV-2 S protein is identified, revealing that S-ERM interactions are specifically conserved among high...
• Tantalum alloy-based resonators for quantum information systems AI翻译
  作者：Yang, Chen; Bahrami, Faranak; Cheng, Guangming; Feldman, Mayer; Liu, Tiffany; Shumiya, Nana; Yao, Nan; Lyon, Stephen A.; Houck, Andrew A.; de Leon, Nathalie P.; Cava, Robert J.
  作者单位：Princeton University; Princeton University; Princeton University
  摘要：Utilizing tantalum (Ta) in superconducting circuits has led to significant improvements, such as high qubit lifetime (T1) and quality factors in both qubits and resonators, suggesting that material optimization plays an important role in the development of superconducting circuits. Thus we here explore superconducting gap engineering in Ta-based devices as a powerful strategy for expanding the range of suitable host materials. By alloying 20 atomic percent (at.%) hafnium into Ta thin films, we...
• Disorder-induced stress-flow misalignment in soft glassy materials revealed using multidirectional shear AI翻译
  作者：Blanc, Frederic; Ovarlez, Guillaume; Trigui, Adam; Martens, Kirsten; Mari, Romain
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Cote d'Azur; CNRS - Institute of Physics (INP); Centre National de la Recherche Scientifique (CNRS); Universite de Bordeaux; CNRS - Institute of Chemistry (INC); Communaute Universite Grenoble Alpes; Centre National de la Recherche Scientifique (CNRS); Universite Grenoble Alpes (UGA)
  摘要：Controlling the mechanical response of soft glassy materials-such as emulsions, foams, and colloidal suspensions-is key for many industrial processes. While their steady-state flow behavior is reasonably well understood, their response to complex flow histories, as encountered in operations like pumping or mixing, remains poorly known. Using a custom multiaxis shear apparatus that enables arbitrary changes flow direction, we investigate how shear history influences the mechanical behavior a mo...
• How much of the forest sink is passive? Case of the United States AI翻译
  作者：Davis, Eric C.; Sohngen, Brent; Lewis, David J.
  作者单位：United States Department of Agriculture (USDA); University System of Ohio; Ohio State University; Oregon State University
  摘要：Over time, carbon sequestered in temperate forests has increased, but the relative effects of passive and active drivers remain unclear. This study uses plot-level data to disentangle the contributions of six drivers (temperature, precipitation, CO2, management, age composition, and area) to these increases in 14 forest groups of the conterminous United States. From 2005 to 2022, the passive drivers (CO2, temperature, and precipicontributing most of the change. Among the anthropogenic drivers,...
• BORC assemblies integrate BLOC-1 subunits to diversify endosomal trafficking functions AI翻译
  作者：De Araujo, Mariana E. G.; Amann, Sascha J.; Stasyk, Taras; Schleiffer, Alexander; Rauch, Eva; Flumann, Paula; Singer, Isabel I.; Kremser, Leopold; Dostal, Vojtech; Laopanupong, Thanida; Obojes, Nikolaus; Wallnofer, Moritz H.; Gradl, Flora S.; Kurzbauer, Robert; Krebiehl, Caroline; Kofler, Samuel; Grishkovskaya, Irina; Vogel, Georg F.; Hess, Michael W.; Sarg, Bettina; Clausen, Tim; Haselbach, David; Huber, Lukas A.
  作者单位：Medical University of Innsbruck; Vienna Biocenter (VBC); Research Institute of Molecular Pathology (IMP); University of Vienna; Vienna Biocenter (VBC); Medical University of Vienna; Medical University of Vienna; Medical University of Innsbruck; European Academy of Bozen-Bolzano; Medical University of Innsbruck; Medical University of Innsbruck
  摘要：BORC and BLOC-1 are multisubunit complexes that regulate endolysosomal trafficking. Although they are presumed to be distinct, their paralogous origins and shared subunits suggest the potential for higher-order assembly. Here, we reveal the conserved octameric architecture of BORC formed by two intertwined tetramers and present the structure of C. elegans BORC. Through cross-linking mass spectrometry of endogenous complexes, we validate this model for human BORC and demonstrate that the integr...
• Reply to Dujmović: The alignment in cost between human and model reasoning is an empirical phenomenon worth explaining AI翻译
  作者：de Varda, Andrea Gregor; D'Elia, Ferdinando Pio; Kean, Hope; Lampinen, Andrew; Fedorenko, Evelina
  作者单位：Massachusetts Institute of Technology (MIT); University of Copenhagen; Alphabet Inc.; DeepMind
• Clever algorithms for glasses work by time reparameterization AI翻译
  作者：Ghimenti, Federico; Berthier, Ludovic; Kurchan, Jorge; van Wijland, Frederic
  作者单位：Universite Paris Cite; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); Stanford University; Universite de Montpellier; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); Centre National de la Recherche Scientifique (CNRS); Universite PSL; CNRS - Institute of Chemistry (INC); Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Universite PSL; Universite Paris Cite; Ecole Normale Superieure (ENS)
  摘要：The ultraslow dynamics of glass-formers has been explained by two views often considered as mutually exclusive: One invokes locally hindered mobility, and the other rests on the complexity of the configuration space. Here, we show that time evolution responds strongly to details of the dynamics by changing the speed of time flow: It has time-reparameterization softness. This finding reconciles both views: While local constraints reparameterize the flow of time, the global landscape determines ...
• Evolutionary adaptations to the hormonal regulation of vascular tissue development AI翻译
  作者：Xiao, Wei; Verhelst, Eline; Yang, Ling; Ke, Yuji; De Rybel, Bert
  作者单位：Ghent University; Flanders Institute for Biotechnology (VIB); Chinese Academy of Sciences; South China Botanical Garden, CAS; Chinese Academy of Sciences; South China Botanical Garden, CAS
  摘要：Vascular tissues provide long-distance transport and physical support in the vascular plant lineage, providing a significant adaptive advantage. Although the cross talk between auxin and cytokinin in promoting both vascular cell proliferation and differentiation has been well studied in angiosperms such as Arabidopsis thaliana, little is known about this regulation in other vascular plant lineages. Here, we found that unlike the hormonal cross talk found in all other species under study, the l...