2026

最新文章

• Emergent ferromagnetism and unusual irreversible magnetoresistance in an intercalated van der Waals antiferromagnet AI翻译
  作者：Zhai, Zixin; Liu, Wenhao; Guo, Xiaoyu; Schulze, Daniel J.; Kuo, Ting -Wei; Agarwal, Nishkarsh; Stangel, Alex; Joshi, Pramanand; Liu, J. Ping; Deng, Liangzi; Hovden, Robert; Zhao, Liuyan; Chu, Ching -Wu; Lv, Bing
  作者单位：University of Texas System; University of Texas Dallas; University of Michigan System; University of Michigan; University of Houston System; University of Houston; University of Houston System; University of Houston; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Texas System; University of Texas Arlington
  摘要：Orthorhombic air-stable two-dimensional (2D) antiferromagnet (AFM) CrSBr has attracted much research interest lately thanks to its rich magnetic behaviors together with its remarkable electronic, excitonic, and polaritonic properties. Here, we report a reliable electrochemical intercalation method by inserting large tetrabutylammonium (TBA+) ions into CrSBr layers. Magnetically, such intercalation efficiently suppresses the interlayer AFM and induces a ferromagnetic (FM) order with a much-enha...
• When broken bones need air: Erythrocytes step in to heal AI翻译
  作者：Blecher, Ronen; Zelzer, Elazar
  作者单位：Ben-Gurion University of the Negev; Samson Assuta Ashdod University Hospital; Weizmann Institute of Science
• Phosphatase SHP2 pathogenic mutations enhance activity by altering conformational sampling AI翻译
  作者：Glaser, Andrew W.; Padua, Ricardo A. P.; Ojoawo, Adedolapo M.; Sullivan, Camille; Kern, Dorothee
  作者单位：Brandeis University; Howard Hughes Medical Institute; Scripps Research Institute; Howard Hughes Medical Institute
  摘要：SH2 domains are critical mediators of cellular signaling, although the molecular mechanisms by which they bind their phosphopeptide ligands remain incompletely understood. We investigate the atomic mechanisms underlying both healthy regulation and dysregulation of the human protein tyrosine phosphatase SHP2, a key regulator of cellular signaling. While most pathogenic mutations cluster near the PTP/N-SH2 interface, the E139D and T42A mutations are located within the regulatory SH2 domains, and...
• Targeting C1q signaling in fibro-adipogenic progenitors prevents regenerative fibrosis of aged muscle AI翻译
  作者：Kanugovi, Abhijnya; Aguiari, Paola; Choi, Rachel; Kim, Soochi; Wu, Di; De Morree, Antoine; Bui, Summer; Lam, Richard; Biressi, Stefano; Liu, Ling; Rando, Thomas A.
  作者单位：Stanford Medicine; Stanford University; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of Trento; Korea University; Aarhus University
  摘要：Skeletal muscle fibrosis, as occurs with age, in response to injury, or in the setting of degenerative diseases, results in impairments of muscle regeneration and function. chymal progenitor cells that reside in the muscle interstitium, play a crucial role in normal muscle regeneration by supporting muscle stem cell proliferation. However, in pathological conditions such as severe or recurrent muscle injury, FAPs can aberrantly differentiate into fibrogenic cells, resulting in excessive deposi...
• Estimating US savings on outpatient prescription pharmaceuticals from international reference pricing AI翻译
  作者：Ye, Yang; Pandey, Abhishek; Fitzpatrick, Meagan C.; Potter-Schwartz, Lilia; Bawden, Carolyn; Bilori, Bilori; Singer, Burton H.; Galvani, Alison P.
  作者单位：Yale University; University System of Maryland; University of Maryland Baltimore; State University System of Florida; University of Florida
  摘要：The exorbitant cost of prescription pharmaceuticals is a critical and long-standing concern facing the United States (US). To curb rising drug costs, international reference pricing, aligning drug prices with those in other high-income countries, has emerged as a prominent policy option. We evaluated the potential national savings from such a strategy in the United States through a comprehensive analysis of utilization patterns and global price differentials for over 8,000 drugs. We project an...
• Shouldering the challenge of deciphering avian palate evolution AI翻译
  作者：Benito, Juan; Kuo, Pei-Chen; Torres, Christopher R.; Navalon, Guillermo; Plateau, Olivia; Clark, Alexander D.; Steell, Elizabeth M.; Field, Daniel J.
  作者单位：University of Cambridge; Universidad de Alcala; University of Bern; University of Cambridge
• Circular RNA-based therapy targeting metabolic vulnerability of fatty acid synthesis overcomes castration-resistant prostate cancer AI翻译
  作者：Lin, Yudong; Wang, Ruyue; Li, Fan; Lu, Zeyi; Luo, Wenqin; Lu, Haohua; Xu, Zhehao; Xu, Chang; Lu, Yi; Zhu, Ziwei; Li, Yang; Mao, Xudong; Xia, Liqun; Yu, Xiaojing; Su, Wenjing; Ding, Lifeng; Li, Gonghui
  作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University
  摘要：Androgen receptor (AR) signaling is essential for prostate cancer (PCa) cell growth and remains a key therapeutic target in castration-resistant PCa (CRPC). While circular RNAs (circRNAs) are increasingly recognized as important regulatory molecules, their roles in AR signaling during PCa progression remain poorly understood. This study identified circUTRN, an AR-inhibited circRNA that is upregulated following neoadjuvant hormonal therapy and downregulated in PCa tissues. circUTRN inhibits pro...
• Ebola virus matrix protein VP40 triggers inflammatory responses linked to the ebolavirus virulence AI翻译
  作者：Yamaoka, Satoko; M'hamdi, Zeineb; Wang, Lin; Swenson, Vaille A.; Mcnally, Kristin L.; Lu, Shao -Chia; Singh, Reema; Saundh, Stephanie L.; Zell, Brady N.; Best, Sonja M.; Barry, Michael A.; Rasmussen, Angela L.; Ebihara, Hideki
  作者单位：Mayo Clinic; University of Saskatchewan; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Mayo Clinic; University of Saskatchewan; State University of New York (SUNY) System; Stony Brook University; Japan Institute for Health Security (JIHS); National Institute of Infectious Diseases (NIID)
  摘要：Uncontrolled systemic inflammatory responses are a critical pathological feature of fatal Ebola virus (EBOV) infection. While some inflammatory responses may originate and may be an important source of inflammation. Here, we demonstrated that highly virulent EBOV induced a high and sustained pro-inflammatory response compared vation. We identified the EBOV matrix protein VP40 as a potent activator of NF-kappa B proteins from less virulent ebolaviruses. This suggests that VP40 is a virulence de...
• Maintaining microbiota across diverse symbiotic organs in Euprymna scolopes: Insights into shared immune responses AI翻译
  作者：Vijayan, Nidhi; Briseno, John; Simakov, Oleg; Nyholm, Spencer V.
  作者单位：University of Connecticut; University of Vienna
  摘要：Many animals have multiple organs or tissues that are colonized by diverse microbiota. The female Hawaiian bobtail squid, Euprymna scolopes, has two organs with distinct symbiotic communities: the accessory nidamental gland (ANG) and the light organ (LO). The ANG hosts a bacterial consortium, whereas the LO has a binary relationship with Vibrio fischeri, housed in extracellular crypt spaces as part of the central core (CC). scriptomics to identify immune- related genes that are uniquely and si...
• Developmental plasticity has important implications for plant domestication research AI翻译
  作者：Gremillion, Kristen J.