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作者：Tong, Kangkang
作者单位：Shanghai Jiao Tong University
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作者：Wu, Qinci; Li, Zhongrui; Han, Bingchen; Sun, Weiyu; Liu, Qinyun; Xue, Chengyuan; Bae, Hyeonhu; Wang, Mengdi; Fu, Boyang; Qian, Jun; Zhu, Yongchao; Sun, Yu; Feng, Tingkai; Gao, Xin; Cong, Xuzhong; Liu, Wanqing; Gao, Yunan; Yan, Binghai; Tan, Congwei; Liu, Hongtao; Peng, Hailin
作者单位：Peking University; Chinese Academy of Sciences; Peking University; Peking University; Peking University; Weizmann Institute of Science; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
摘要：Ferroelectrics have great potential for nonvolatile memory and next-generation electronics, but conventional ferroelectric oxide films generally suffer structural nonuniformity, interfacial depolarization, and performance degradation, particularly when downscaled to advanced technology nodes. We demonstrate uniform, wafer-scale synthesis and back-end-of-line-compatible integration of ultrathin van der Waals (vdW) high-dielectric constant ferroelectric oxide Bi2SeO5, retaining an optimal coerci...
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作者：Gao, Lei; Qiu, Xiang; Yang, Jun; Hu, Kangdelong; Li, Peilin; Li, Wei; Gao, Feng; Gallou, Fabrice; Kleinbeck, Florian; Lei, Xiaoguang
作者单位：Peking University; Wuhan University; Peking University; Novartis
摘要：Amide bond formation is widely used in pharmaceutical synthesis, typically involving stoichiometric coupling reagents to activate carboxylic acid substrates for a condensation reaction. As an alternative approach, we repurposed aldehyde dehydrogenases into oxidative amidases by creating a more hydrophobic and spacious catalytic pocket for amines to capture the thioester intermediate. This biocatalyst efficiently facilitates the formation of amide bonds between diverse aldehydes and amines. We ...
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作者：Guo, Jason; Liang, Roger; Chung, Andrew; Li, Zhijie; Li, Boyuan; Chen, Eric; Li, Lin; Wang, Jingjing; Hsieh, Meng-Hsiung; Fang, Ivy Xiangyi; Kroger, Benjamin; Wang, Yunguan; Zhu, Min; Ren, Xiongzhao; Mannino, Greg; Jia, Yuemeng; Wei, Yonglong; Moore, Stephen; Siegwart, Daniel J.; Chung, Stephen S.; Wang, Zixi; Sharma, Tripti; Komjeti, Suman; Han, Yi; Gopal, Purva; Xiao, Guanghua; Wang, Tao; Zhu, Hao
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University System of Ohio; Cincinnati Children's Hospital Medical Center; University of Cincinnati; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
摘要：The origin of cancer is poorly understood because premalignant cells are rarely followed in their native environments. Although the spatial compartmentalization of metabolic functions is critical for proper liver function, it is unknown whether cancers arise from some zones but not others and whether there are metabolic determinants of cancer risk. Zone-specific, mosaic introduction of Ctnnb1 (catenin beta 1) and Arid2 (AT-rich interaction domain 2) mutations, commonly co-mutated genes in hepa...
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作者：Tomaskovic, Ines; Prieto-Garcia, Cristian; Boskovic, Maria; Glumac, Mateo; Tsai, Tsung-Lin; Mosler, Thorsten; Kazi, Rubina; Rathore, Rajeshwari; Andrade, Jorge; Hoffmann, Marina; Giuliani, Giulio; Jacomin, Anne-Claire; Pereira, Raquel S.; Knop, Elias; Wachsmuth, Laurens; Beli, Petra; Husnjak, Koraljka; Pasparakis, Manolis; Ablasser, Andrea; Krause, Daniela S.; Potente, Michael; Papathanasiou, Stamatis; Terzic, Janos; Dikic, Ivan
作者单位：Goethe University Frankfurt; Goethe University Frankfurt Hospital; University of Split; Institute of Molecular Biology (IMB); Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Goethe University Frankfurt; Goethe University Frankfurt; University of Cologne; University of Cologne; University of Cologne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ)
摘要：DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease SPRTN in preventing DPC-driven immunity and its pathological consequences. Loss of SPRTN activity during replication and mitosis lead to unresolved DNA damage, chromosome segregation errors, micronuclei formation, and cytosolic DNA release that activates the cyclic GMP-AMP synthase (cGAS)-stimula...
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作者：Kang, Jengmin; Benjamin, Daniel I.; Guo, Qiqi; Evangelista, Chauncey; Kim, Soochi; Arjona, Marina; Both, Pieter; Chung, Mingyu; Krishnan, Ananya K.; Dhaliwal, Gurkamal; Lam, Richard; Rando, Thomas A.
作者单位：Stanford University; Stanford Medicine; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; Stanford University
摘要：Aging is characterized by a decline in the ability of tissue repair and regeneration after injury. In skeletal muscle, this decline is largely driven by impaired function of muscle stem cells (MuSCs) to efficiently contribute to muscle regeneration. We uncovered a cause of this aging-associated dysfunction: a cellular survivorship bias that prioritizes stem cell persistence at the expense of functionality. With age, MuSCs increased expression of a tumor suppressor, N-myc down-regulated gene 1 ...
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作者：Liu, Lei; Wang, Yushu; Dong, Ruikang; Fan, Dongxu; Meng, Si; Wu, Lang; Wu, Shengqiang; Xu, Wei; Feng, Mingwei; Zou, Ningmu; Yan, Qingyu; Hu, Zehua; Lu, Fei; Zhu, Shitong; Gao, Yuan; Ma, Liang; Shi, Yi; Li, Taotao; Wang, Jinlan; Wang, Xinran
作者单位：Suzhou Laboratory; Nanjing University; Nanjing University; Nanjing University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Nanjing University; Southeast University - China
摘要：Kinetics determine the growth behavior of thin films, particularly for atomically thin transition-metal dichalcogenides. Metal-organic (MO) chemical vapor deposition (CVD) offers promise for scalable growth, but the reactions are kinetically limited, leading to nanometer-scale domain size and carbon contaminations. Here, we unveil the fundamental kinetic limitations and overcome them by introducing oxygen-assisted MOCVD (oxy-MOCVD) technology. By tuning reactions with oxygen, MO precursors are...
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作者：Chisholm, C. S.; Hirthe, S.; Makhalov, V. B.; Ramos, R.; Vatre, R.; Cabedo, J.; Celi, A.; Tarruell, L.
作者单位：Barcelona Institute of Science & Technology; Universitat Politecnica de Catalunya; Institut de Ciencies Fotoniques (ICFO); Autonomous University of Barcelona; ICREA
摘要：Spin-orbit-coupled Bose-Einstein condensates are a flexible experimental platform to engineer synthetic quantum many-body systems. In particular, they host the so-called stripe phase, an instance of a supersolid state of matter. The peculiar excitation spectrum of the stripe phase, a definite footprint of its supersolidity, has been difficult to measure experimentally. In this work, we performed in situ imaging of the stripes and directly observed both superfluid and crystal excitations. We in...
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作者：Jones, Nicola
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作者：Service, Robert F.
