6784期

最新文章

• Planning policy undermines UK's nature goals AI翻译
  作者：Elves-Powell, Joshua; Axmacher, Jan C.; Edwards, Joan
  作者单位：University of London; University College London; Zoological Society of London
• Paying resilience forward AI翻译
  作者：Zahir, Zohra
  作者单位：University of Toronto
• The great government brain drain AI翻译
  作者：Hersher, Monica; Mervis, Jeffrey
• High-resolution geodetic velocities reveal role of weak faults in deformation of Tibetan Plateau AI翻译
  作者：Wright, T. J.; Houseman, G. A.; Fang, J.; Maghsoudi, Y.; Hooper, A. J.; Elliott, J. R.; Evans, L.; Lazecky, M.; Ou, Q.; Parsons, B. E.; Rollins, J. C.; Shen, L.; Wang, H.; Wang, D.
  作者单位：University of Leeds; China University of Geosciences; University of Exeter; Monash University; University of Edinburgh; University of Oxford; Earth Sciences New Zealand; GNS Science - New Zealand; Columbia University; South China Agricultural University
  摘要：Understanding the key mechanisms that control the tectonic deformation of the continents remains a fundamental challenge in geodynamics. We present a high-resolution geodetic velocity field of the Tibetan Plateau, which shows that a few major strike-slip fault systems separate regions of more uniformly distributed deformation. We suggest that focused strain on major fault systems is enabled by relatively low-viscosity ductile shear zones extending through the lithosphere beneath the seismicall...
• Multiple protein structure alignment at scale with FoldMason AI翻译
  作者：Gilchrist, Cameron L. M.; Mirdita, Milot; Steinegger, Martin
  作者单位：Seoul National University (SNU); Korea Basic Science Institute (KBSI); Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU); Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU)
  摘要：Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended our repository of available protein structures, requiring fast and accurate MSTA methods. We introduce FoldMason, a progressive MSTA method that leverages the pairwise structural aligners Foldseek and TM-align for the multiple alignment of hundreds of thousands of protein structures, matching or exc...
• Should I stay or should I go with them? AI翻译
  作者：Todd, Peter M.; Hills, Thomas T.
  作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; University of Warwick
• Rethinking the heritability of aging: The genetic contribution to human longevity is greater than previously thought AI翻译
  作者：Bakula, Daniela; Scheibye-Knudsen, Morten
  作者单位：University of Copenhagen
• A global imperative to remediate Ukraine's soils AI翻译
  作者：He, Erkai; Qiu, Hao; Peijnenburg, Willie J. G. M.
  作者单位：East China Normal University; Shanghai Jiao Tong University; Netherlands National Institute for Public Health & the Environment; Leiden University; Leiden University - Excl LUMC
• From sequence to function: Bridging single-molecule kinetics and molecular diversity AI翻译
  作者：Kapanidis, A. N.; Muras, L.; Sreenivasa, K.; Hazra, J. P.; van Noort, J.; Joo, C.; Deindl, S.
  作者单位：University of Oxford; University of Oxford; Uppsala University; Delft University of Technology; Leiden University; Leiden University - Excl LUMC; Ewha Womans University
  摘要：Biological function is fundamentally determined by nucleic acid and protein sequence. Beyond encoding genetic information, nucleic acids also display complex physicochemical parameters that shape structure, dynamics, and interactions. Understanding how sequence variation sculpts the energetic landscapes underlying these properties requires methods that capture both molecular diversity and dynamic behavior. Single-molecule techniques are ideally suited to this task, but conventional formats rem...
• Fossil energy minimum viable scale AI翻译
  作者：Lappen, Joshua; Grubert, Emily
  作者单位：University of Notre Dame