6784期

最新文章

• Muscle stem cells trade functionality for survival AI翻译
  作者：von Maltzahn, Julia
  作者单位：Brandenburg University of Technology Cottbus; Brandenburg University of Technology Cottbus; Leibniz Association; Leibniz Institut fur Alternsforschung - Fritz-Lipmann-Institut (FLI)
• Soils drive convergence in the regulation of vascular tension in land plants AI翻译
  作者：Carminati, Andrea; Javaux, Mathieu; Wankmuller, Fabian J. P.; Brodribb, Timothy J.
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Helmholtz Association; Julich Research Centre; University of Tasmania
  摘要：Terrestrial vascular plants operate under negative water potential, which results in hydraulic tension in the vascular system. Vascular tension varies with transpiration and soil drying and is regulated by stomata, pressure-activated valves on the leaf surface. We hypothesize that soil physical constraints drive convergence in the operational range of leaf vascular tension. Based on a meta analysis of 19 diverse species, we find that stomatal regulation of transpiration is activated when leaf ...
• The evolution of gene regulation in mammalian cerebellum development AI翻译
  作者：Sarropoulos, Ioannis; Sepp, Mari; Yamada, Tetsuya; Schafer, Philipp S. L.; Trost, Nils; Schmidt, Julia; Schneider, Celine; Drummer, Charis; Missbach, Sophie; Taskiran, Ibrahim I.; Hecker, Nikolai; Bravo Gonzalez-Blas, Carmen; Fromel, Robert; Joshi, Piyush; Leushkin, Evgeny; Arnskotter, Frederik; Leiss, Kevin; Okonechnikov, Konstantin; Lisgo, Steven; Palkovits, Miklos; Paabo, Svante; Cardoso-Moreira, Margarida; Kutscher, Lena M.; Behr, Rudiger; Pfister, Stefan M.; Aerts, Stein; Kaessmann, Henrik
  作者单位：Ruprecht Karls University Heidelberg; Helmholtz Association; German Cancer Research Center (DKFZ); Leibniz Association; Deutsches Primatenzentrum (DPZ); Flanders Institute for Biotechnology (VIB); KU Leuven; Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ); Newcastle University - UK; Semmelweis University; Max Planck Society; Okinawa Institute of Science & Technology Graduate University; Francis Crick Institute; Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Helmholtz Association; National Center for Tumor Diseases; German Cancer Research Center (DKFZ); Wellcome Trust Sanger Institute; University of Cambridge; University of Cambridge; University of Tartu
  摘要：Gene regulatory changes are considered major drivers of evolutionary innovations, including the cerebellum's expansion during human evolution, yet they remain largely unexplored. In this study, we combined single-nucleus measurements of gene expression and chromatin accessibility from six mammals (human, bonobo, macaque, marmoset, mouse, and opossum) to uncover conserved and diverged regulatory networks in cerebellum development. We identified core regulators of cell identity and developed seq...
• The Great Shadow AI翻译
  作者：Klestinec, Cynthia
  作者单位：University System of Ohio; Miami University; University System of Ohio; Miami University
• China turns the tables in biotech AI翻译
  作者：Thorp, H. Holden
• Aging drives a program of DNA methylation decay in plant organs AI翻译
  作者：Dai, Dawei; Chen, Ken; Tao, Jingwen; Williams, Ben P.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：Plants display a wide range of life spans and aging rates. Although dynamic changes to DNA methylation are a hallmark of aging in mammals, it is unclear whether similar molecular signatures reflect rates of aging and organism life span in plants. In this work, we show that the short-lived model plant Arabidopsis thaliana exhibits a loss of epigenetic integrity during aging, which causes DNA methylation decay and the expression of transposable elements. We show that the rate of epigenetic aging...
• Earthquake sensors buried in the quietest spot on Earth AI翻译
  作者：Richter, Hannah
• Heritability of intrinsic human life span is about 50% when confounding factors are addressed AI翻译
  作者：Shenhar, Ben; Pridham, Glen; De Oliveira, Thais Lopes; Raz, Naveh; Yang, Yifan; Deelen, Joris; Hagg, Sara; Alon, Uri
  作者单位：Weizmann Institute of Science; Karolinska Institutet; Westlake University; Leiden University; Leiden University - Excl LUMC; Leiden University Medical Center (LUMC)
  摘要：How heritable is human life span? If genetic heritability is high, longevity genes can reveal aging mechanisms and inform medicine and public health. However, current estimates of heritability are low-twin studies show heritability of only 20 to 25%, and recent large pedigree studies suggest it is as low as 6%. Here we show that these estimates are confounded by extrinsic mortality-deaths caused by extrinsic factors such as accidents or infections. We use mathematical modeling and analyses of ...
• Art Cure: The Science of How the Arts Save Lives AI翻译
  作者：Wai, Jonathan
  作者单位：University of Arkansas System; University of Arkansas Fayetteville; University of Arkansas System; University of Arkansas Fayetteville
• Solving the ferroelectric scaling trilemma: A robust oxide ferroelectric-semiconductor interface realizes an energy-efficient memory for computing AI翻译
  作者：Behera, Piush; Cheema, Suraj S.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)