2026

最新文章

• Complex interplay of neuronal and hormonal gut-brain responses to essential amino acid deficit AI翻译
  作者：Kim, Boram; Lee, Seongju; Bae, Hyeyeon; Kim, Shinhye; Won, Jong-Hoon; Kim, Dongwoo; Jung, Byungkwon; Kanai, Makoto I.; Yoon, Sung-Eun; Oh, Yangkyun; Lee, Won-Jae; Suh, Greg S. B.
  作者单位：Korea Advanced Institute of Science & Technology (KAIST); Institute for Basic Science - Korea (IBS); Gwangju Institute of Science & Technology (GIST); New York University; Gwangju Institute of Science & Technology (GIST); Ewha Womans University; Seoul National University (SNU); Gwangju Institute of Science & Technology (GIST); Osaka Metropolitan University
  摘要：A deficit in dietary protein elicits a nutrient-specific appetite, yet the underlying mechanisms remain poorly understood. In this work, we identify coordinated neuronal and systemic mechanisms in Drosophila that drive an essential amino acid (EAA)-specific appetite. EAA deprivation increases neuropeptide CNMamide (CNMa) expression in gut enterocytes, activating enteric neurons and ellipsoid body neurons in the brain to promote EAA intake through two complementary pathways: a rapid neuronal gu...
• Implantable living materials autonomously deliver therapeutics using contained engineered bacteria AI翻译
  作者：Harimoto, Tetsuhiro; Herrero Quevedo, Fernando; Zillig, Janis; Schreiber, Sanjay; Wu, Yi; Ahn, Christine Heera; To, Tania; Thakur, Rohan; Tatara, Alexander M.; Kang, Shawn; Chen, Zheqi; Lafuente-Gomez, Nuria; Hanan, Blake; Pauer, Alexander; Lightbown, Shanda; Weitz, David A.; Mooney, David J.
  作者单位：Harvard University; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Texas System; University of Texas Southwestern Medical Center; Harvard University
  摘要：Microbes are increasingly used as living therapeutics, yet their uncontrolled dissemination in the body has remained a clinical roadblock. Physical containment remains largely unattainable owing to eventual bacteria escape. In this work, we present an implantable material that encapsulates and confines bacteria, wherein synthetically engineered microbes produce therapeutic payloads from within. We developed a hydrogel scaffold with dual mechanical features: high stiffness to regulate bacterial...
• Dementia studies come to grips with overlapping diseases AI翻译
  作者：Smith, Jennie Erin
• Knowledge gaps for neuromorphic ionic computing AI翻译
  作者：Aluru, Narayana R.; Darling, Seth B.; Elam, Jeffrey W.; Gang, Oleg; Salleo, Alberto; Siwy, Zuzanna; Talin, A. Alec; Noy, Aleksandr
  作者单位：University of Texas System; University of Texas Austin; United States Department of Energy (DOE); Argonne National Laboratory; University of Chicago; United States Department of Energy (DOE); Argonne National Laboratory; Columbia University; Columbia University; United States Department of Energy (DOE); Brookhaven National Laboratory; United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory; Stanford University; University of California System; University of California Irvine; United States Department of Energy (DOE); Sandia National Laboratories; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; University of California System; University of California Merced
  摘要：Neuromorphic ionic computing is inspired by the brain's use of ions for ultralow-energy computation-its massive parallelism, adaptability, and learning capabilities. This emerging paradigm can overcome limitations of conventional silicon-based computing by enabling colocated memory and processing, multicarrier information streams, and massive three-dimensional connectivity. However, substantial knowledge gaps remain in understanding and engineering ionic transport, energy dissipation, material...
• Bizarre Hawking radiation may smooth the jagged hearts of black holes AI翻译
  作者：Cho, Adrian
• Foot-and-mouth disease explodes in South Africa AI翻译
  作者：Pennisi, Elizabeth
• A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex AI翻译
  作者：Vuong, Celine K.; Weber, Alexis; Seong, Patrick; Matoba, Nana; Chen, Yu-Jen; Peyer, Jordan; Younesi, Shahab; Salinda, Angelo; Gomez, Daniel; Rivas, Gabriella; Morales, Abril; Shafie, Beck; Zhang, Pan; Nichterwitz, Susanne; Qi, Le; Fernandez, Nolan T.; Friedman, Emily; Love, Michael I.; Gandal, Michael J.; Geschwind, Daniel H.; Lowry, William E.; Stein, Jason L.; de la Torre-Ubieta, Luis
  作者单位：University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Fudan University
  摘要：Down syndrome (DS) is the most common genetic cause of intellectual disability, yet the cellular and molecular mechanisms driving this developmental disorder remain unclear. In this study, we profiled human mid-gestation neocortex with snMultiomics across 26 donors. We observed a reduction in neural progenitors and corticothalamic neurons and an increase of intratelencephalic neurons, accompanied by accelerated neuronal specification. We uncovered widespread changes in gene expression, chromat...
• Mapping transcription factor functions in astrocytes using in vivo gain-of-function Perturb-seq AI翻译
  作者：Zhang, Liansheng; Ma, Qi; Kong, Xiangrui; Zou, Weijuan; Wang, Bo; Wu, Bin; Cai, Shicheng; Bai, Tao; Tan, Runlin; Dai, Ziji; Liu, Xingyu; Jia, Zhiheng; Zhang, Meimei; Li, Tianwen; Zheng, Yuanyi; Hu, Xinde; Wu, Jianrong; Xu, Zhengzheng; Zhou, Haibo
  作者单位：Chinese Academy of Sciences; Center for Excellence in Brain Science and Intelligence Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Jiao Tong University; Fudan University; Fudan University; Shanghai Center for Brain Science & Brain-Inspired Technology
  摘要：An in vivo approach combining high-throughput screening with cell type-specific readouts could enable elucidation of genotype-phenotype relationships in complex tissues. We developed an in vivo gain-of-function Perturb-seq platform, termed iGOF-Perturb-seq, to build a functional atlas of similar to 1000 transcription factors (TFs) in astrocytes, a cell type essential to many brain functions. We then identified cofunctional modules, annotated uncharacterized TFs, and predicted disease-associate...
• Programmable cellular protein factories AI翻译
  作者：James, Richard G.; Zhang, Ting-ting
  作者单位：Seattle Children's Hospital; Seattle Children's Hospital; University of Washington; University of Washington Seattle
• Blind box culture exacerbates plastic waste AI翻译
  作者：Tu, Weiming
  作者单位：Nanyang Technological University; Nanyang Technological University; Danish Hydraulic Institute (DHI)