4期

最新文章

• HIV-1 capsid shape, orientation, and entropic elasticity regulate translocation into the nuclear pore complex AI翻译
  作者：Hudait, Arpa; Voth, Gregory A.
  作者单位：University of Chicago; University of Chicago
  摘要：Nuclear import and uncoating of the viral capsid are critical steps in the HIV - 1 life cycle that serve to transport and release genomic material into the nucleus. Viral core import involves translocating the HIV - 1 capsid at the nuclear pore complex (NPC). Notably, the central channel of the NPC appears to often accommodate and allow passage of intact HIV - 1 capsid, though mechanistic details of the process remain to be fully understood. Here, we investigate the molecular interactions that...
• Reverse transcriptase inhibitors prevent liver abscess formation during Escherichia coli bloodstream infection AI翻译
  作者：Hullahalli, Karthik; Dailey, Katherine G.; Hasegawa, Yuko; Johnson, Welkin E.; Waldor, Matthew K.
  作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Boston College
  摘要：The presence of bacteria in the bloodstream is associated with severe clinical outcomes. In mice, intravenous inoculation of Escherichia coli can lead to the formation of macroscopic abscesses in the liver. Abscesses are regions of severe necrosis and consist of millions of bacteria surrounded by inflammatory immune cells. Liver abscess susceptibility varies widely across strains of mice, but the host factors governing this variation are unknown. Here, we profiled hepatic transcriptomes in mic...
• Diamond spins making waves again AI翻译
  作者：Burkard, Guido
  作者单位：University of Konstanz
• Continuous ammonia synthesis from water and nitrogen via contact electrification AI翻译
  作者：Li, Juan; Xia, Yu; Song, Xiaowei; Chen, Bolei; Zare, Richard N.
  作者单位：Jianghan University; Stanford University
  摘要：We synthesized ammonia (NH3) by bubbling nitrogen (N-2) gas into bulk liquid water (200 mL) containing 50 mg polytetrafluoroethylene (PTFE) particles (similar to 5 mu m in diameter) suspended with the help of a surfactant (Tween 20, similar to 0.05 vol.%) at room temperature (25 degrees C). Electron spin resonance spectroscopy and density functional theory calculations reveal that water acts as the proton donor for the reduction of N2. Moreover, isotopic labeling of the N2 gas shows that it is...
• Embedding electronic perpetual motion into single-atom catalysts for persistent Fenton-like reactions AI翻译
  作者：Chen, Fei; Sun, Yi-Jiao; Huang, Xin-Tong; Bai, Chang-Wei; Zhang, Zhi-Quan; Duan, Pi-Jun; Chen, Xin-Jia; Yang, Qi; Yu, Han-Qing
  作者单位：Chongqing University; Hunan University; Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：In our quest to leverage the capabilities of the emerging single-atom catalysts (SACs) for wastewater purification, we confronted fundamental challenges related to electron scarcity and instability. Through meticulous theoretical calculations, we identified optimal placements for nitrogen vacancies (Nv) and iron (Fe) single-atom sites, uncovering a dual-site approach that significantly amplified visible-light absorption and charge transfer dynamics. Informed by these computational insights, we...
• Flying, nectar-loaded honey bees conserve water and improve heat tolerance by reducing wingbeat frequency and metabolic heat production AI翻译
  作者：Glass, Jordan R.; Burnett, Nicholas P.; Combes, Stacey A.; Weisman, Ethan; Helbling, Alina; Harrison, Jon F.
  作者单位：Arizona State University; Arizona State University-Tempe; University of Wyoming; University of California System; University of California Davis
  摘要：Heat waves are becoming increasingly common due to climate change, making it crucial to identify and understand the capacities for insect pollinators, such as honey bees, to avoid overheating. We examined the effects of hot, dry air temperatures on the physiological and behavioral mechanisms that honey bees use to fly when carrying nectar loads, to assess how foraging is limited by overheating or desiccation. We found that flight muscle temperatures increased linearly with load mass at air tem...
• Remembering MS Swaminathan: An outstanding scientist and visionary leader AI翻译
  作者：Khush, Gurdev S.; McCouch, Susan R.; Ronald, Pamela C.
  作者单位：University of California System; University of California Davis; University of California System; University of California Davis; Cornell University
• Fast quantum interference of a nanoparticle via optical potential control AI翻译
  作者：Neumeier, Lukas; Ciampini, Mario A.; Romero-Isart, Oriol; Aspelmeyer, Markus; Kiesel, Nikolai
  作者单位：University of Vienna; Austrian Academy of Sciences; University of Innsbruck; Austrian Academy of Sciences
  摘要：We introduce and theoretically analyze a scheme to prepare and detect non-Gaussian quantum states of an optically levitated particle via the interaction with light pulses that generate cubic and inverted potentials. We show that this approach allows to operate on sufficiently short time- and length scales to beat decoherence in a regime accessible in state-of-the-art experiments. Specifically, we predict the observation of single-particle interference of a nanoparticle with a mass above 10(8) ...
• Spatiotemporal trends of hemorrhagic fever with renal syndrome (HFRS) in China under climate variation AI翻译
  作者：Wang, Yuchen; Zhang, Chutian; Gao, Jing; Chen, Ziqi; Liu, Zhao; Huang, Jianbin; Chen, Yidan; Li, Zhichao; Chang, Nan; Tao, Yuxin; Tang, Hui; Gao, Xuejie; Xu, Ying; Wang, Can; Li, Dong; Liu, Xiaobo; Pan, Jingxiang; Cai, Wenjia; Gong, Peng; Luo, Yong; Liang, Wannian; Liu, Qiyong; Stenseth, Nils Chr.; Yang, Ruifu; Xu, Lei
  作者单位：Tsinghua University; Tsinghua University; Karolinska Institutet; University of Helsinki; University of Helsinki; Helsinki University Central Hospital; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Tsinghua University; Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS; Nanjing Medical University; Tsinghua University; University of Oslo; University of Oslo; University of Helsinki; Chinese Academy of Sciences; Institute of Atmospheric Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; China Meteorological Administration; Chinese Center for Disease Control & Prevention; National Institute for Communicable Disease Control & Prevention, Chinese Center for Disease Control & Prevention; Cornell University; Tsinghua University; University of Hong Kong; University of Oslo; University of Oslo; Beijing Institute of Microbiology & Epidemiology
  摘要：Hemorrhagic fever with renal syndrome (HFRS) is a zoonotic disease caused by the rodent-transmitted orthohantaviruses (HVs), with China possessing the most cases globally. The virus hosts in China are Apodemus agrarius and Rattus norvegicus, and the disease spread is strongly influenced by global climate dynamics. To assess and predict the spatiotemporal trends of HFRS from 2005 to 2098, we collected historical HFRS data in mainland China (2005-2020), historical and projected climate and popul...
• A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer AI翻译
  作者：Cencic, Regina; Im, Young K.; Naineni, Sai Kiran; Moustafa-Kamal, Mohamed; Jovanovic, Predrag; Sabourin, Valerie; Annis, Matthew G.; Robert, Francis; Schmeing, T. Martin; Koromilas, Antonis; Paquet, Marilene; Teodoro, Jose G.; Huang, Sidong; Siegel, Peter M.; Topisirovic, Ivan; Ursini-Siegel, Josie; Pelletier, Jerry
  作者单位：McGill University; McGill University; Lady Davis Institute; McGill University; McGill University; Universite de Montreal; McGill University
  摘要：In this study, we aimed to address the current limitations of therapies for macro-metastatic triple-negative breast cancer (TNBC) and provide a therapeutic lead that overcomes the high degree of heterogeneity associated with this disease. Specifically, we focused on well-documented but clinically underexploited cancer-fueling perturbations in mRNA translation as a potential therapeutic vulnerability. We therefore developed an orally bioavailable rocaglate-based molecule, MG-002, which hinders ...