4期

最新文章

• Working- age mortality is still an important driver of stagnating life expectancy in the United States AI翻译
  作者：Polizzi, Antonino; Dowd, Jennifer Beam
  作者单位：University of Oxford; University of Oxford; University of Oxford; University of Oxford
• Adipose- tissue regulatory T cells are a consortium of subtypes that evolves with age and diet AI翻译
  作者：Munoz-Rojas, Andres R.; Wang, Gang; Benoist, Christophe; Mathis, Diane
  作者单位：Harvard University; Harvard Medical School
  摘要：Foxp3+CD4+ regulatory T (Treg) cells found within tissues regulate local immunity, inflammation, and homeostasis. Tregs in epididymal visceral adipose tissue (eVAT) are critical regulators of local and systemic inflammation and metabolism. During aging and under obesogenic conditions, eVAT Tregs undergo transcriptional and phenotypic changes and are important for containing inflammation and normalizing metabolic indices. We have employed single - cell RNA sequencing, single - cell Tra and Trb ...
• Diamond spins making waves again AI翻译
  作者：Burkard, Guido
  作者单位：University of Konstanz
• Precise coordination of high-loading Fe single atoms with sulfur boosts selective generation of nonradicals AI翻译
  作者：Jiang, Xunheng; Zhou, Binghui; Yang, Weijie; Chen, Jiayi; Miao, Chen; Guo, Zhongyuan; Li, Hao; Hou, Yang; Xu, Xinhua; Zhu, Lizhong; Lin, Daohui; Xu, Jiang
  作者单位：Zhejiang University; North China Electric Power University; Zhejiang University; Tohoku University; Zhejiang University
  摘要：Nonradicals are effective in selectively degrading electron-rich organic contaminants, which unfortunately suffer from unsatisfactory yield and uncontrollable composition due to the competitive generation of radicals. Herein, we precisely construct a local microenvironment of the carbon nitride-supported high-loading (similar to 9 wt.%) Fe single-atom catalyst (Fe SAC) with sulfur via a facile supermolecular self-assembly strategy. Short-distance S coordination boosts the peroxymonosulfate (PM...
• Prevention efficacy of the broadly neutralizing antibody VRC01 depends on HIV-1 envelope sequence features AI翻译
  作者：Juraska, Michal; Bai, Hongjun; deCamp, Allan C.; Magaret, Craig A.; Li, Li; Gillespie, Kevin; Carpp, Lindsay N.; Giorgi, Elena E.; Ludwig, James; Molitor, Cindy; Hudson, Aaron; Williamson, Brian D.; Espy, Nicole; Simpkins, Brian; Rudnicki, Erika; Shao, Danica; Rossenkhan, Raabya; Edlefsen, Paul T.; Westfall, Dylan H.; Deng, Wenjie; Chen, Lennie; Zhao, Hong; Bhattacharya, Tanmoy; Pankow, Alec; Murrell, Ben; Yssel, Anna; Matten, David; York, Talita; Beaume, Nicolas; Gwashu-Nyangiwe, Asanda; Ndabambi, Nonkululeko; Thebus, Ruwayhida; Karuna, Shelly T.; Morris, Lynn; Montefiori, David C.; Hural, John A.; Cohen, Myron S.; Corey, Lawrence; Rolland, Morgane; Gilbert, Peter B.; Williamson, Carolyn; Mullins, James I.
  作者单位：Fred Hutchinson Cancer Center; United States Department of Defense; United States Army; Walter Reed Army Institute of Research (WRAIR); Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc; Kaiser Permanente; Claremont Colleges; Pitzer College; University of Washington; University of Washington Seattle; United States Department of Energy (DOE); Los Alamos National Laboratory; Karolinska Institutet; University of Cape Town; University of Cape Town; National Health Laboratory Service; National Institute for Communicable Diseases (NICD); University of Witwatersrand; University of Kwazulu Natal; Duke University; University of North Carolina; University of North Carolina Chapel Hill; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：In the Antibody Mediated Prevention (AMP) trials (HVTN 704/HPTN 085 and HVTN 703/HPTN 081), prevention efficacy (PE) of the monoclonal broadly neutralizing anti-body (bnAb) VRC01 (vs. placebo) against HIV-1 acquisition diagnosis varied according to the HIV-1 Envelope (Env) neutralization sensitivity to VRC01, as measured by 80% inhibitory concentration (IC80). Here, we performed a genotypic sieve analysis, a complementary approach to gaining insight into correlates of protection that assesses ...
• Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells AI翻译
  作者：Urena, Enric; Xu, Bowen; Regan, Jennifer C.; Atilano, Magda L.; Minkley, Lucy J.; Filer, Danny; Lu, Yu-Xuan; Bolukbasi, Ekin; Khericha, Mobina; Alic, Nazif; Partridge, Linda
  作者单位：University of London; University College London; Max Planck Society; University of Edinburgh
  摘要：Pharmacological therapies are promising interventions to slow down aging and reduce multimorbidity in the elderly. Studies in animal models are the first step toward translation of candidate molecules into human therapies, as they aim to elucidate the molecular pathways, cellular mechanisms, and tissue pathologies involved in the anti-aging effects. Trametinib, an allosteric inhibitor of MEK within the Ras/MAPK (Ras/Mitogen-Activated Protein Kinase) pathway and currently used as an anti-cancer...
• The shape of the Himalayan Arc: An ellipse pinned by syntaxial strike-slip fault tips AI翻译
  作者：Jiao, Liqing; Tapponnier, Paul; Mccallum, Aurelie Coudurier-Curveur; Xu, Xiwei
  作者单位：China Geological Survey; Chinese Academy of Geological Sciences; China University of Geosciences
  摘要：Trans-Himalayan geodetic data show that, between both syntaxes, India/Asia convergence is steadily oriented approximate to N20 degrees E. However, surface faulting near both syntaxes, along the 2005 and 1950 earthquake ruptures, imply long-term thrusting directed approximate to 130 degrees apart, and post-LGM (last Glacial Maximum) shortening rates of approximate to 5 to 6 mm/y, approximate to 2 to 3 times slower than in Nepal (approximate to 15 to 20 mm/y). Syntaxial earthquakes' return-time ...
• A TeZla micromixer for interrogating the early and broad folding landscape of G-quadruplex via multistage velocity descending AI翻译
  作者：Li, Zheyu; Hu, Rui; Li, Tao; Zhu, Jiang; You, Huijuan; Li, Yiwei; Liu, Bi-Feng; Li, Conggang; Li, Ying; Yang, Yunhuang
  作者单位：Huazhong University of Science & Technology; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Huazhong University of Science & Technology; Huazhong University of Science & Technology
  摘要：Biomacromolecular folding kinetics involves fast folding events and broad timescales. Current techniques face limitations in either the required time resolution or the observation window. In this study, we developed the TeZla micromixer, integrating Tesla and Zigzag microstructures with a multistage velocity descending strategy. TeZla achieves a significant short mixing dead time (40 mu s) and a wide time window covering four orders of magnitude (up to 300 ms). Using this unique micromixer, we...
• Adaptive cooling strategy via human hair: High optothermal conversion efficiency of solar radiation into thermal dissipation AI翻译
  作者：Pal, Sudip Kumar; Jeong, Soohyun; Otoufat, Tohid; Bae, Hoyeon; Kim, Gunwoo
  作者单位：Korea Institute of Industrial Technology (KITECH)
  摘要：Natural species have developed complex nanostructures in a hierarchical pattern to control the absorption, reflection, or transmission of desired solar and infrared wavelengths. This bio- inspired structure is a promising method to manipulating solar energy and thermal management. In particular, human hair is used in this article to highlight the optothermal properties of bio- inspired structures. This study investigated how melanin, an effective solar absorber, and the structural morphology o...
• γδ T cell antigen receptor polyspecificity enables T cell responses to a broad range of immune challenges AI翻译
  作者：Guo, Jing; Chowdhury, Roshni Roy; Mallajosyula, Vamsee; Xie, Jianming; Dubey, Megha; Liu, Yuanyuan; Li, Jing; Wei, Yu-ling; Palanski, Brad A.; Wang, Conghua; Qiu, Lingfeng; Ohanyan, Mane; Kask, Oliver; Sola, Elsa; Kamalyan, Lilit; Lewis, David B.; Scriba, Thomas J.; Davis, Mark M.; Dodd, Dylan; Zeng, Xun; Chien, Yueh-hsiu
  作者单位：University of Chicago; Western University of Health Sciences; Amgen; University of California System; University of California Santa Cruz; Arizona State University; Arizona State University-Tempe; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Zhejiang University; Zhejiang University; Collaborative Innovation Center for Diagnosis & Treatment of Infectious Diseases; Stanford University; University of Cape Town; University of Cape Town; Stanford University; Howard Hughes Medical Institute; Chinese Academy of Medical Sciences - Peking Union Medical College
  摘要：gamma delta T cells are essential for immune defense and modulating physiological processes. While they have the potential to recognize large numbers of antigens through somatic gene rearrangement, the antigens which trigger most gamma delta T cell response remain unidentified, and the role of antigen recognition in gamma delta T cell function is contentious. Here, we show that some gamma delta T cell receptors (TCRs) exhibit polyspecificity, recognizing multiple ligands of diverse molecular n...