4期

最新文章

• High UV damage and low repair, but not cytosine deamination, stimulate mutation hotspots at ETS binding sites in melanoma AI翻译
  作者：Duan, Mingrui; Song, Shenghan; Wasserman, Hana; Lee, Po-Hsuen; Liu, Ke Jian; Gordan, Raluca; He, Yi; Mao, Peng
  作者单位：University of New Mexico; University of New Mexico; University of New Mexico; Duke University; State University of New York (SUNY) System; Stony Brook University; Duke University; Duke University; Duke University
  摘要：Noncoding mutation hotspots have been identified in melanoma and many of them occur at the binding sites of E26 transformation-specific (ETS) proteins; however, their formation mechanism and functional impacts are not fully understood. Here, we used UV (Ultraviolet) damage sequencing data and analyzed cyclobutane pyrimidine dimer (CPD) formation, DNA repair, and CPD deamination in human cells at single-nucleotide resolution. Our data show prominent CPD hotspots immediately after UV irradiation...
• Interfacial solvation-structure regulation for stable Li metal anode by a desolvation coating technique AI翻译
  作者：Li, Guo-Xing; Lennartz, Peter; Koverga, Volodymyr; Kou, Rong; Au Nguyen; Jiang, Heng; Liao, Meng; Wang, Daiwei; Dandu, Naveen; Zepeda, Michael; Wang, Haiying; Wang, Ke; Ngo, Anh T.; Brunklaus, Gunther; Wang, Donghai
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Helmholtz Association; Research Center Julich; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; United States Department of Energy (DOE); Argonne National Laboratory; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
  摘要：Rechargeable lithium (Li) metal batteries face challenges in achieving stable cycling due to the instability of the solid electrolyte interphase (SEI). The Li-ion solvation structure and its desolvation process are crucial for the formation of a stable SEI on Li metal anodes and improving Li plating/stripping kinetics. This research introduces an interfacial desolvation coating technique to actively modulate the Li-ion solvation structure at the Li metal interface and regulate the participatio...
• Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope AI翻译
  作者：Liu, X. F.; Onda, M.; Schlomer, J.; Bassel, L.; Kozlov, S.; Tai, C. -H.; Zhou, Q.; Liu, W.; Tsao, H. -E.; Hassan, R.; Ho, M.; Pastan, I.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
  摘要：Despite many clinical trials, CAR-T cells are not yet approved for human solid tumor therapy. One popular target is mesothelin (MSLN) which is highly expressed on the surface of about 30% of cancers including mesothelioma and cancers of the ovary, pancreas, and lung. MSLN is shed by proteases that cleave near the C terminus, leaving a short peptide attached to the cell. Most anti-MSLN antibodies bind to shed MSLN, which can prevent their binding to target cells. To overcome this limitation, we...
• The spacefor- time gambit fails a robust test AI翻译
  作者：Angert, Amy L.
  作者单位：University of British Columbia
• Precise coordination of high- loading Fe single atoms with sulfur boosts selective generation of nonradicals AI翻译
  作者：Jiang, Xunheng; Zhou, Binghui; Yang, Weijie; Chen, Jiayi; Miao, Chen; Guo, Zhongyuan; Li, Hao; Hou, Yang; Xu, Xinhua; Zhu, Lizhong; Lin, Daohui; Xu, Jiang
  作者单位：Zhejiang University; North China Electric Power University; Zhejiang University; Tohoku University; Zhejiang University
  摘要：Nonradicals are effective in selectively degrading electron- rich organic contaminants, which unfortunately suffer from unsatisfactory yield and uncontrollable composition due to the competitive generation of radicals. Herein, we precisely construct a local microenvironment of the carbon nitride-supported high- loading (similar to 9 wt.%) Fe single- atom catalyst (Fe SAC) with sulfur via a facile supermolecular self- assembly strategy. Short- distance S coordination boosts the peroxymonosulfat...
• Efficient mapping of the thalamocortical monosynaptic connectivity in vivo by tangential insertions of high-density electrodes in the cortex AI翻译
  作者：Sibille, Jeremie; Gehr, Carolin; Kremkow, Jens
  作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin
  摘要：The thalamus provides the principal input to the cortex and therefore understanding the mechanisms underlying cortical integration of sensory inputs requires to characterize the thalamocortical connectivity in behaving animals. Here, we propose tangential insertions of high-density electrodes into mouse cortical layer 4 as a method to capture the activity of thalamocortical axons simultaneously with their synaptically connected cortical neurons. This technique can reliably monitor multiple par...
• Quantitative comparison of nuclear transport inhibition by SARS coronavirus ORF6 reveals the importance of oligomerization AI翻译
  作者：Yoo, Tae Yeon; Mitchison, Timothy J.
  作者单位：Harvard University; Harvard Medical School
  摘要：Open Reading Frame 6 (ORF6) proteins, which are unique to severe acute respiratory syndrome-related (SARS) coronavirus, inhibit the classical nuclear import pathway to antagonize host antiviral responses. Several alternative models were proposed to explain the inhibitory function of ORF6 [H. Xia et al., Cell Rep. 33, 108234 (2020); L. Miorin et al., Proc. Natl. Acad. Sci. U.S.A. 117, 28344-28354 (2020); and M. Frieman et al., J. Virol. 81, 9812-9824 (2007)]. To distinguish these models and bui...
• Slow closure of Earth's carbon cycle AI翻译
  作者：Rothman, Daniel H.
  作者单位：Massachusetts Institute of Technology (MIT)
  摘要：Carbon near the Earth's surface cycles between the production and consumption of organic carbon; the former sequesters carbon dioxide while the latter releases it. Microbes attempt to close the loop, but the longer organic matter survives, the slower microbial degradation becomes. This aging effect leaves observable quantitative signatures: Organic matter decays at rates that are inversely proportional to its age, while microbial populations and concentrations of organic carbon in ocean sedime...
• Repurposing dasatinib for diffuse large B cell lymphoma (vol 116, pg 16981, 2019) AI翻译
  作者：Scuoppo, Claudio; Wang, Jiguang; Persaud, Mirjana; Mittan, Sandeep K.; Basso, Katia; Pasqualucci, Laura; Rabadan, Raul; Inghirami, Giorgio; Grandori, Carla; Bosch, Francesc; Dalla-Favera, Riccardo
• Model-free characterization of topological edge and corner states in mechanical networks AI翻译
  作者：Guzman, Marcelo; Guo, Xiaofei; Coulais, Corentin; Carpentier, David; Bartolo, Denis
  作者单位：Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); University of Pennsylvania; University of Amsterdam
  摘要：Topological materials can host edge and corner states that are protected from disorder and material imperfections. In particular, the topological edge states of mechanical structures present unmatched opportunities for achieving robust responses in wave guiding, sensing, computation, and filtering. However, determining whether a mechanical structure is topologically nontrivial and features topologically protected modes has hitherto relied on theoretical models. This strong requirement has limi...