7期

最新文章

• Top-down versus bottom-up oxidation of a neonicotinoid pesticide by OH radicals AI翻译
  作者：Wang, Xinke; Wang, Weihong; Wingen, Lisa M.; Perraud, Veronique; Finlayson-Pitts, Barbara J.
  作者单位：University of California System; University of California Irvine
  摘要：Emerging contaminants (EC) distributed on surfaces in the environment can be oxidized by gas phase species (top-down) or by oxidants generated by the underlying substrate (bottom-up). One class of EC is the neonicotinoid (NN) pesticides that are widely distributed in air, water, and on plant and soil surfaces as well as on airborne dust and building materials. This study investigates the OH oxidation of the systemic NN pesticide acetamiprid (ACM) at room temperature. ACM on particles and as th...
• Real- time tracking of electron transfer at catalytically active interfaces in lithium- ion batteries AI翻译
  作者：Li, Hongsen; Hu, Zhengqiang; Zuo, Fengkai; Li, Yuhao; Liu, Minhui; Liu, Hengjun; Li, Yadong; Li, Qiang; Ding, Yu; Wang, Yaqun; Zhu, Yue; Yu, Guihua; Maier, Joachim; Cui, Yi
  作者单位：Qingdao University; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; Nanjing University; Shandong University of Science & Technology; Max Planck Society
  摘要：Transition metals and related compounds are known to exhibit high catalytic activities in various electrochemical reactions thanks to their intriguing electronic structures. What is lesser known is their unique role in storing and transferring electrons in battery electrodes which undergo additional solid - state conversion reactions and exhibit substantially large extra capacities. Here, a full dynamic picture depicting the generation and evolution of electrochemical interfaces in the presenc...
• Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism AI翻译
  作者：Macleod, Kenneth; Coquelin, Kevin-Sebastien; Huertas, Leticia; Simeons, Frederick R. C.; Riley, Jennifer; Casado, Patricia; Guijarro, Laura; Casanueva, Ruth; Frame, Laura; Pinto, Erika G.; Ferguson, Liam; Duncan, Christina; Mutter, Nicole; Shishikura, Yoko; Henderson, Colin J.; Cebrian, David; Wolf, C. Roland; Read, Kevin D.
  作者单位：University of Dundee; University of Dundee; GlaxoSmithKline; Glaxosmithkline United Kingdom
  摘要：A key step in drug discovery, common to many disease areas, is preclinical demonstration of efficacy in a mouse model of disease. However, this demonstration and its translation to the clinic can be impeded by mouse- specific pathways of drug metabolism. Here, we show that a mouse line extensively humanized for the cytochrome P450 gene superfamily (8HUM) can circumvent these problems. The pharmacokinetics, metabolite profiles, and magnitude of drug-drug interactions of a test set of approved m...
• Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma AI翻译
  作者：Sainero-Alcolado, Lourdes; Garde-Lapido, Elisa; Snaebjornsson, Marteinn Thor; Schoch, Sarah; Stevens, Irene; Ruiz-Perez, Maria Victoria; Dyrager, Christine; Pelechano, Vicent; Axelson, Hakan; Schulze, Almut; Arsenian-Henriksson, Marie
  作者单位：Karolinska Institutet; Helmholtz Association; German Cancer Research Center (DKFZ); Lund University; Karolinska Institutet; Uppsala University
  摘要：Metabolic reprogramming is critical during clear cell renal cell carcinoma (ccRCC) tumorigenesis, manifested by accumulation of lipid droplets (LDs), organelles that have emerged as new hallmarks of cancer. Yet, regulation of their biogenesis is still poorly understood. Here, we demonstrate that MYC inhibition in ccRCC cells lacking the von Hippel Lindau (VHL) gene leads to increased triglyceride content potentiating LD formation in a glutamine- dependent manner. Importantly, the concurrent in...
• S1 basic leucine zipper transcription factors shape plant architecture by controlling C/N partitioning to apical and lateral organs AI翻译
  作者：Kreisz, Philipp; Hellens, Alicia M.; Froeschel, Christian; Krischke, Markus; Maag, Daniel; Feil, Regina; Wildenhain, Theresa; Draken, Jan; Braune, Gabriel; Erdelitsch, Leon; Cecchino, Laura; Wagner, Tobias C.; Ache, Peter; Mueller, Martin J.; Becker, Dirk; Lunn, John E.; Hanson, Johannes; Beveridge, Christine A.; Fichtner, Franziska; Barbier, Francois F.; Weiste, Christoph
  作者单位：University of Wurzburg; University of Queensland; University of Queensland; Max Planck Society; University of Wurzburg; Umea University; Heinrich Heine University Dusseldorf; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; INRAE
  摘要：Plants tightly control growth of their lateral organs, which led to the concept of apical dominance. However, outgrowth of the dormant lateral primordia is sensitive to the plant's nutritional status, resulting in an immense plasticity in plant architecture. While the impact of hormonal regulation on apical dominance is well characterized, the prime importance of sugar signaling to unleash lateral organ formation has just recently emerged. Here, we aimed to identify transcriptional regulators,...
• A biochemical description of postsynaptic plasticity-with timescales ranging from milliseconds to seconds AI翻译
  作者：Li, Guanchun; McLaughlin, David W.; Peskin, Charles S.
  作者单位：New York University; New York University; New York University; New York University; NYU Shanghai; NYU Langone Medical Center; New York University; Howard Hughes Medical Institute; Baylor College of Medicine
  摘要：Synaptic plasticity [long-term potentiation/depression (LTP/D)], is a cellular mechanism underlying learning. Two distinct types of early LTP/D (E-LTP/D), acting on very different time scales, have been observed experimentally-spike timing dependent plasticity (STDP), on time scales of tens of ms; and behavioral time scale synaptic plasticity (BTSP), on time scales of seconds. BTSP is a candidate for a mechanism underlying rapid learning of spatial location by place cells. Here, a computationa...
• The shape of Nature's stingers revealed AI翻译
  作者：Quan, Haocheng; Liang, Xudong; Zhang, Xuan; Meyers, Marc A.; Mcmeeking, Robert M.; Arzt, Eduard
  作者单位：Nanjing University; Leibniz Association; Leibniz Institut fur Neue Materialien (INM); Harbin Institute of Technology; Peking University; University of California System; University of California San Diego; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; Saarland University; University of California System; University of California San Diego
  摘要：Stinger - like structures in living organisms evolved convergently across taxa for both defensive and offensive purposes, with the main goal being penetration and damage. Our observations over a broad range of taxa and sizes, from microscopic radiolarians to narwhals, reveal a self- similar geometry of the stinger extremity: the diameter (d) increases along the distance from the tip (x) following a power law x similar to dn, with the tapering exponent varying universally between 2 and 3. We de...
• Ancient trees are essential elements for high- mountain forest conservation: Linking the longevity of trees to their ecological function AI翻译
  作者：Pasques, Ot; Munne-Bosch, Sergi
  作者单位：University of Barcelona; University of Barcelona
  摘要：Mature forests and their extremely old trees are rare and threatened ancient vestiges in remote European high- mountain regions. Here, we analyze the role that extremely long - living trees have in mature forests biodiversity in relation to their singular traits underlying longevity. Tree size and age determine relative growth rates, bud abortion, and the water status of long- living trees. The oldest trees suffer indefectible age- related constraints but possess singular evolutionary traits d...
• Isolation, characterization, and circulation sphere of a filovirus in fruit bats AI翻译
  作者：He, Biao; Hu, Tingsong; Yan, Xiaomin; Pa, Yanhui; Liu, Yuhang; Liu, Yang; Li, Nan; Yu, Jing; Zhang, Hailin; Liu, Yonghua; Chai, Jun; Sun, Yue; Mi, Shijiang; Liu, Yan; Yi, Le; Tu, Zhongzhong; Wang, Yiyin; Sun, Sheng; Feng, Ye; Zhang, Wendong; Zhao, Huanyun; Duan, Bofang; Gong, Wenjie; Zhang, Fuqiang; Tu, Changchun
  作者单位：Chinese Academy of Agricultural Sciences; Yunnan Institute for Endemic Disease Control & Prevention; Yunnan Agricultural University; Jilin University; Yangzhou University
  摘要：Bats are associated with the circulation of most mammalian filoviruses (FiVs), with pathogenic ones frequently causing deadly hemorrhagic fevers in Africa. Divergent FiVs have been uncovered in Chinese bats, raising concerns about their threat to public health. Here, we describe a long-term surveillance to track bat FiVs at orchards, eventually resulting in the identification and isolation of a FiV, Dehong virus (DEHV), from Rousettus leschenaultii bats. DEHV has a typical filovirus-like morph...
• Modulation of active center distance of hybrid perovskite for boosting photocatalytic reduction of carbon dioxide to ethylene AI翻译
  作者：Li, Linjuan; Xu, Dawei; Xu, Xiankui; Tian, Zheng; Zhou, Xue; Yang, Shenbo; Zhang, Zhonghai
  作者单位：East China Normal University; East China Normal University
  摘要：Solar- driven photocatalytic CO2 reduction is an energy- efficient and sustainable strategy to mitigate CO2 levels in the atmosphere. However, efficient and selective conversion of CO2 into multi- carbon products, like C2H4, remains a great challenge due to slow multi- electron- proton transfer and sluggish C-C coupling. Herein, a two- dimensional thin- layered hybrid perovskite is fabricated through filling of oxygen into iodine vacancy in pristine DMASnI3 (DMA = dimethylammonium). The ration...