7期

最新文章

• Molecular basis for human aquaporin inhibition AI翻译
  作者：Huang, Peng; Abacka, Hannah; Wilson, Carter J.; Wind, Malene Lykke; Rutzler, Michael; Hagstroem-Andersson, Anna; Gourdon, Pontus; de Groot, Bert L.; Venskutonyte, Raminta; Lindkvist-Petersson, Karin
  作者单位：Lund University; University of Copenhagen; Lund University; Lund University
  摘要：Cancer invasion and metastasis are known to be potentiated by the expression of aquaporins (AQPs). Likewise, the expression levels of AQPs have been shown to be prognostic for survival in patients and have a role in tumor growth, edema, angiogenesis, and tumor cell migration. Thus, AQPs are key players in cancer biology and potential targets for drug development. Here, we present the single- particle cryo- EM structure of human AQP7 at 3.2- angstrom resolution in complex with the specific inhi...
• Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex (vol 121, e2405041121, 2024) AI翻译
  作者：Guo, Qian; Chen, Kai-en; Gimenez-Andres, Manuel; Jellett, Adam P.; Gao, Ya; Simonetti, Boris; Liu, Meihan; Danson, Chris M.; Heesom, Kate J.; Cullen, Peter J.; Collins, Brett M.
• Self-replication of A/342 aggregates occurs on small and isolated fibril sites AI翻译
  作者：Curk, Samo; Krausser, Johannes; Meisl, Georg; Frenkel, Daan; Linse, Sara; Michaels, Thomas C. T.; Knowles, Tuomas P. J.; Saric, Andela
  作者单位：Institute of Science & Technology - Austria; University of London; University College London; University of Cambridge; Lund University; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Self -replication of amyloid fibrils via secondary nucleation is an intriguing physicochemical phenomenon in which existing fibrils catalyze the formation of their own copies. The molecular events behind this fibril surface -mediated process remain largely inaccessible to current structural and imaging techniques. Using statistical mechanics, computer modeling, and chemical kinetics, we show that the catalytic structure of the fibril surface can be inferred from the aggregation behavior in the...
• The growing inadequacy of an open- ended Saffir-Simpson hurricane wind scale in a warming world AI翻译
  作者：Wehner, Michael F.; Kossin, James P.
  作者单位：United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Wisconsin System; University of Wisconsin Madison
  摘要：Global warming increases available sensible and latent heat energy, increasing the thermodynamic potential wind intensity of tropical cyclones (TCs). Supported by theory, observations, and modeling, this causes a shift in mean TC intensity, which tends to manifest most clearly at the greatest intensities. The Saffir-Simpson scale for categorizing damage based on the wind intensity of TCs was introduced in the early 1970s and remains the most commonly used metric for public communication of the...
• Coordination of rhythmic RNA synthesis and degradation orchestrates 24-and 12-h RNA expression patterns in mouse fibroblasts AI翻译
  作者：Unruh, Benjamin A.; Weidemann, Douglas E.; Miao, Lin; Kojima, Shihoko
  作者单位：Virginia Polytechnic Institute & State University
  摘要：Circadian RNA expression is essential to ultimately regulate a plethora of downstream rhythmic biochemical, physiological, and behavioral processes. Both transcriptional and posttranscriptional mechanisms are considered important to drive rhythmic RNA expression; however, the extent to which each regulatory process contributes to the rhythmic RNA expression remains controversial. To systematically address this, we monitored RNA dynamics using metabolic RNA labeling technology during a circadia...
• The elementary reactions for incorporation into crystals AI翻译
  作者：Chakrabarti, Rajshree; Verma, Lakshmanji; Hadjiev, Viktor G.; Palmer, Jeremy C.; Vekilov, Peter G.
  作者单位：University of Houston System; University of Houston; University of Houston System; University of Houston; University of Houston System; University of Houston
  摘要：The growth rates of crystals are largely dictated by the chemical reaction between solute and kinks, in which a solute molecule severs its bonds with the solvent and establishes new bonds with the kink. Details on this sequence of bond breaking and rebuilding remain poorly understood. To elucidate the reaction at the kinks we employ four solvents with distinct functionalities as reporters on the microscopic structures and their dynamics along the pathway into a kink. We combine time- resolved ...
• Learning beyond- pairwise interactions enables the bottom-up prediction of microbial community structure AI翻译
  作者：Ishizawa, Hidehiro; Tashiro, Yosuke; Inoue, Daisuke; Ike, Michihiko; Futamata, Hiroyuki
  作者单位：University of Hyogo; Shizuoka University; Shizuoka University; Shizuoka University; University of Osaka
  摘要：Understanding the assembly of multispecies microbial communities represents a significant challenge in ecology and has wide applications in agriculture, wastewater treatment, and human healthcare domains. Traditionally, studies on the microbial community assembly focused on analyzing pairwise relationships among species; however, neglecting higher - order interactions, i.e., the change of pairwise relationships in the community context, may lead to substantial deviation from reality. Herein, w...
• The interplay between the circadian clock and abiotic stress responses mediated by ABF3 and CCA1/LHY AI翻译
  作者：Liang, Tong; Yu, Shi; Pan, Yuanzhong; Wang, Jiarui; Kay, Steve A.
  作者单位：University of Southern California
  摘要：Climate change is a global concern for all life on our planet, including humans and plants. Plants' growth and development are significantly affected by abiotic stresses, including adverse temperature, inadequate or excess water availability, nutrient deficiency, and salinity. The circadian clock is a master regulator of numerous developmental and metabolic processes in plants. In an effort to identify new clock- related genes and outputs through bioinformatic analysis, we have revealed that C...
• Design of universal Ebola virus vaccine candidates via immunofocusing AI翻译
  作者：Xu, Duo; Powell, Abigail E.; Utz, Ashley; Sanyal, Mrinmoy; Do, Jonathan; Patten, J. J.; Moliva, Juan I.; Sullivan, Nancy J.; Davey, Robert A.; Kim, Peter S.
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Boston University; Boston University; Boston University; Chan Zuckerberg Initiative (CZI)
  摘要：The Ebola virus causes hemorrhagic fever in humans and poses a significant threat to global public health. Although two viral vector vaccines have been approved to prevent Ebola virus disease, they are distributed in the limited ring vaccination setting and only indicated for prevention of infection from orthoebolavirus zairense (EBOV)- one of three orthoebolavirus species that have caused previous outbreaks. Ebola virus glycoprotein GP mediates viral infection and serves as the primary target...
• Retinoic acid receptor α activity in proximal tubules prevents kidney injury and fibrosis AI翻译
  作者：Dikun, Krysta M.; Tang, Xiao- Han; Fu, Leiping; Choi, Mary E.; Lu, Changyuan; Gudas, Lorraine J.
  作者单位：Cornell University; Weill Cornell Medicine; Cornell University; NewYork-Presbyterian Hospital; Cornell University; Weill Cornell Medicine
  摘要：Chronic kidney disease (CKD) is characterized by a gradual loss of kidney function and affects -13.4% of the global population. Progressive tubulointerstitial fibrosis, driven in part by proximal tubule (PT) damage, is a hallmark of late stages of CKD and contributes to the development of kidney failure, for which there are limited treatment options. Normal kidney development requires signaling by vitamin A (retinol), which is metabolized to retinoic acid (RA), an endogenous agonist for the RA...