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• A massive alteration of gene expression in undescended testicles of dogs and the association of KAT6A variants with cryptorchidism AI翻译
  作者：Stachowiak, Monika; Nowacka-Woszuk, Joanna; Szabelska-Beresewicz, Alicja; Zyprych-Walczak, Joanna; Krzeminska, Paulina; Sosinski, Oskar; Nowak, Tomasz; Switonski, Marek
  作者单位：Poznan University of Life Sciences; Poznan University of Life Sciences; Polish Academy of Sciences; Institute of Bioorganic Chemistry of the Polish Academy of Sciences
  摘要：Cryptorchidism is the most common form of disorder of sex development in male dogs, but its hereditary predisposition is poorly elucidated. The gonadal transcriptome of nine unilaterally cryptorchid dogs and seven control dogs was analyzed using RNA-seq. Comparison between the scrotal and inguinal gonads of unilateral cryptorchid dogs revealed 8,028 differentially expressed genes (DEGs) (3,377 up- regulated and 4,651 down- regulated). A similar number of DEGs (7,619) was found by comparing the...
• A bioenergy- focused versus a reforestation- focused mitigation pathway yields disparate carbon storage and climate responses AI翻译
  作者：Cheng, Yanyan; Lawrence, David M.; Pan, Ming; Zhang, Baoqing; Graham, Neal T.; Lawrence, Peter J.; Liu, Zhongfang; He, Xiaogang
  作者单位：National University of Singapore; National Science Foundation (NSF); National Center Atmospheric Research (NCAR) - USA; University of California System; University of California San Diego; Scripps Institution of Oceanography; Lanzhou University; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Tongji University; National University of Singapore
  摘要：Limiting global warming to 2 degrees C requires urgent action on land - based mitigation. This study evaluates the biogeochemical and biogeophysical implications of two alternative land - based mitigation scenarios that aim to achieve the same radiative forcing. One scenario is primarily driven by bioenergy expansion (SSP226Lu- BIOCROP), while the other involves re/afforestation (SSP126Lu- REFOREST). We find that overall, SSP126Lu- REFOREST is a more efficient strategy for removing CO2 from th...
• The structure of a Cryptococcus neoformans polysaccharide motif recognized by protective antibodies: A combined NMR and MD study AI翻译
  作者：Hargett, Audra A.; Azurmendi, Hugo F.; Crawford, Conor J.; Wear, Maggie P.; Oscarson, Stefan; Casadevall, Arturo; Freedberg, Daron I.
  作者单位：US Food & Drug Administration (FDA); Center for Biologics Evaluation & Research (CBER); Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; University College Dublin; Max Planck Society
  摘要：Cryptococcus neoformans is a fungal pathogen responsible for cryptococcosis and cryptococcal meningitis. The C. neoformans' capsular polysaccharide and its shed exopolysaccharide function both as key virulence factors and to protect the fungal cell from phagocytosis. Currently, a glycoconjugate of these polysaccharides is being explored as a vaccine to protect against C. neoformans infection. In this study, NOE andJ-coupling values from NMR experiments were consistent with a converged structur...
• Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer AI翻译
  作者：Li, Shi-Yang; Hammarlund, Jan A.; Wu, Gang; Lian, Jia-Wen; Howell, Sacha J.; Clarke, Robert B.; Adamson, Antony D.; Goncalves, Catia F.; Hogenesch, John B.; Anafi, Ron C.; Meng, Qing-Jun
  作者单位：University of Manchester; Drexel University; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University of Manchester; University of Pennsylvania
  摘要：Studies in shift workers and model organisms link circadian disruption to breast cancer. However, molecular circadian rhythms in noncancerous and cancerous human breast tissues and their clinical relevance are largely unknown. We reconstructed rhythms informatically, integrating locally collected, time- stamped biopsies with public datasets. For noncancerous breast tissue, inflammatory, epithelial-mesenchymal transition (EMT), and estrogen responsiveness pathways show circadian modulation. Amo...
• Cat 6 hurricanes have arrived AI翻译
  作者：Mann, Michael E.
  作者单位：University of Pennsylvania
• Modulation of α- synuclein in vitro aggregation kinetics by its alternative splice isoforms AI翻译
  作者：Roentgen, Alexander; Toprakcioglu, Zenon; Tomkins, James E.; Vendruscolo, Michele
  作者单位：University of Cambridge
  摘要：The misfolding and aggregation of alpha- synuclein is linked to a family of neurodegenerative disorders known as synucleinopathies, the most prominent of which is Parkinson's disease (PD). Understanding the aggregation process of alpha- synuclein from a mechanistic point of view is thus of key importance. SNCA, the gene encoding alpha- synuclein, comprises six exons and produces various isoforms through alternative splicing. The most abundant isoform is expressed as a 140 - amino acid protein ...
• A nonadaptive explanation for macroevolutionary patterns in the evolution of complex multicellularity AI翻译
  作者：Bingham, Emma P.; Ratcliff, William C.
  作者单位：University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology
  摘要：Complex multicellularity, conventionally defined as large organisms with many specialized cell types, has evolved five times independently in eukaryotes, but never within prokaryotes. A number of hypotheses have been proposed to explain this phenomenon, most of which posit that eukaryotes evolved key traits (e.g., dynamic cytoskeletons, alternative mechanisms of gene regulation, or subcellular compartments) which were a necessary prerequisite for the evolution of complex multicellularity. Here...
• Phase separation of YAP-MAML2 differentially regulates the transcriptome AI翻译
  作者：Chung, Chan-, I; Yang, Junjiao; Yang, Xiaoyu; Liu, Hongjiang; Ma, Zhimin; Szulzewsky, Frank; Holland, Eric C.; Shen, Yin; Shu, Xiaokun
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center
  摘要：Phase separation (PS) drives the formation of biomolecular condensates that are emerging biological structures involved in diverse cellular processes. Recent studies have unveiled PS- induced formation of several transcriptional factor (TF) condensates that are transcriptionally active, but how strongly PS promotes gene activation remains unclear. Here, we show that the oncogenic TF fusion Yes- associated protein 1- Mastermind like transcriptional coactivator 2 (YAP- MAML2) undergoes PS and fo...
• Buckling-induced sound production in the aeroelastic tymbals of Yponomeuta AI翻译
  作者：Nava, Hernaldo Mendoza; Holderied, Marc W.; Pirrera, Alberto; Groh, Rainer M. J.
  作者单位：University of Bristol; University of Bristol
  摘要：The loss of elastic stability (buckling) can lead to catastrophic failure in the context of traditional engineering structures. Conversely, in nature, buckling often serves a desirable function, such as in the prey -trapping mechanism of the Venus fly trap (Dionaea muscipula). This paper investigates the buckling -enabled sound production in the wingbeat-powered (aeroelastic) tymbals of Yponomeuta moths. The hindwings of Yponomeuta possess a striated band of ridges that snap through sequential...
• TM4SF19 controls GABP- dependent YAP transcription in head and neck cancer under oxidative stress conditions AI翻译
  作者：Shin, Eunbie; Kwon, Yongsoo; Jung, Eunji; Kim, Yong Joon; Kim, Changgon; Hong, Semyeong; Kim, Joon
  作者单位：Korea Advanced Institute of Science & Technology (KAIST); Yonsei University; Yonsei University Health System
  摘要：Tobacco and alcohol are risk factors for human papillomavirus-negative head and neck squamous cell carcinoma (HPV- HNSCC), which arises from the mucosal epithelium of the upper aerodigestive tract. Notably, despite the mutagenic potential of smoking, HPV- HNSCC exhibits a low mutational load directly attributed to smoking, which implies an undefined role of smoking in HPV- HNSCC. Elevated YAP (Yes- associated protein) mRNA is prevalent in HPV- HNSCC, irrespective of the YAP gene amplification ...