7期

最新文章

• Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase AI翻译
  作者：Kelly, Abigail G.; Wang, Weicang; Rothenberger, Eva; Yang, Jun; Gilligan, Molly M.; Kipper, Franciele C.; Attaya, Ahmed; Gartung, Allison; Hwang, Sung Hee; Gillespie, Michael J.; Bayer, Rachel L.; Quinlivan, Katherine M.; Torres, Kimberly L.; Huang, Sui; Mitsiades, Nicholas; Yang, Haixia; Hammock, Bruce D.; Panigrahy, Dipak
  作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; University of California System; University of California Davis; University of California System; University of California Davis; Purdue University System; Purdue University; Institute for Systems Biology (ISB); University of California System; University of California Davis; China Agricultural University
  摘要：Cancer therapy, including immunotherapy, is inherently limited by chronic inflammationinduced tumorigenesis and toxicity within the tumor microenvironment. Thus, stimulating the resolution of inflammation may enhance immunotherapy and improve the toxicity of immune checkpoint inhibition (ICI). As epoxy - fatty acids (EpFAs) are degraded by the enzyme soluble epoxide hydrolase (sEH), the inhibition of sEH increases endogenous EpFA levels to promote the resolution of cancer- associated inflammat...
• Modeling and dissociation of intrinsic and input- driven neural population dynamics underlying behavior AI翻译
  作者：Vahidi, Parsa; Sani, Omid G.; Shanechi, Maryam M.
  作者单位：University of Southern California; University of Southern California; University of Southern California; University of Southern California
  摘要：Neural dynamics can reflect intrinsic dynamics or dynamic inputs, such as sensory inputs or inputs from other brain regions. To avoid misinterpreting temporally structured inputs as intrinsic dynamics, dynamical models of neural activity should account for measured inputs. However, incorporating measured inputs remains elusive in joint dynamical modeling of neural- behavioral data, which is important for studying neural computations of behavior. We first show how training dynamical models of n...
• How poverty is measured impacts who gets classified as impoverished AI翻译
  作者：Pu, Christine J.; Lambin, Eric F.; Kusimakwe, Ian; Gichia, Lenny; Seme, Assefa; Otupiri, Easmon; Davis, Jennifer
  作者单位：Stanford University; Stanford University; Stanford University; Universite Catholique Louvain; Addis Ababa University; Kwame Nkrumah University Science & Technology
  摘要：We test whether the classification of households into poverty categories is meaningfully influenced by the poverty measurement approach that is employed. These classification techniques are widely used by governments, non - profit organizations, and development agencies for policy design and implementation. Using primary data collected in Ethiopia, Ghana, and Uganda, we find almost no agreement in how four commonly used approaches rank 16,150 households in terms of poverty status. This result ...
• Structures and organizations of PSI-AcpPCI supercomplexes from red tidal and coral symbiotic photosynthetic dinoflagellates AI翻译
  作者：Li, Xiaoyi; Li, Zhenhua; Wang, Fangfang; Zhao, Songhao; Xu, Caizhe; Mao, Zhiyuan; Duan, Jialin; Feng, Yue; Yang, Yang; Shen, Lili; Wang, Guanglei; Yang, Yanyan; Yu, Long-Jiang; Sang, Min; Han, Guangye; Wang, Xuchu; Kuang, Tingyun; Shen, Jian-Ren; Wang, Wenda
  作者单位：Chinese Academy of Sciences; Institute of Botany, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Tsinghua University; Hainan Normal University; Guizhou University; Okayama University
  摘要：Marine photosynthetic dinoflagellates are a group of successful phytoplankton that can form red tides in the ocean and also symbiosis with corals. These features are closely related to the photosynthetic properties of dinoflagellates. We report here three structures of photosystem I (PSI)-chlorophylls (Chls) a/c- peridinin protein complex (PSI- AcpPCI) from two species of dinoflagellates by single- particle cryoelectron microscopy. The crucial PsaA/B subunits of a red tidal dinoflagellate Amph...
• Deciphering the underlying mechanisms of the pharyngeal pumping motions in Caenorhabditis elegans AI翻译
  作者：Sherman, Dana; Harel, David
  作者单位：Weizmann Institute of Science
  摘要：The pharynx of the nematode Caenorhabditis elegans is a neuromuscular organ that exhibits typical pumping motions, which result in the intake of food particles from the environment. In - depth inspection reveals slightly different dynamics at the various pharyngeal areas, rather than synchronous pumping motions of the whole organ, which are important for its effective functioning. While the different pumping dynamics are well characterized, the underlying mechanisms that generate them are not ...
• Hierarchical assembly is more robust than egalitarian assembly in synthetic capsids AI翻译
  作者：Wei, Wei - Shao; Trubiano, Anthony; Sigl, Christian; Paquay, Stefan; Dietz, Hendrik; Hagan, Michael F.; Fraden, Seth
  作者单位：Brandeis University; Brandeis University; Technical University of Munich; Technical University of Munich
  摘要：Self- assembly of complex and functional materials remains a grand challenge in soft material science. Efficient assembly depends on a delicate balance between thermodynamic and kinetic effects, requiring fine- tuning affinities and concentrations of sub units. By contrast, we introduce an assembly paradigm that allows large error- tolerance in the subunit affinity and helps avoid kinetic traps. Our combined experimental and computational approach uses a model system of triangular subunits pro...
• Peer income exposure across the income distribution AI翻译
  作者：Spiegel, Michelle; Clark, Leah; Domina, Thurston; Penner, Emily K.; Hanselman, Paul; Yoo, Paul Y.; Penner, Andrew
  作者单位：Stanford University; University of North Carolina; University of North Carolina Chapel Hill; University of California System; University of California Irvine; University of California System; University of California Irvine
  摘要：Children from families across the income distribution attend public schools, making schools and classrooms potential sites for interaction between more- and less- affluent children. However, limited information exists regarding the extent of economic integration in these contexts. We merge educational administrative data from Oregon with measures of family income derived from IRS records to document student exposure to economically diverse school and classroom peers. Our findings indicate that...
• Virus- derived circular RNAs populate hepatitis C virus-infected cells AI翻译
  作者：Cao, Qian M.; Boonchuen, Pakpoom; Chen, Tzu-Chun; Lei, Shaohua; Somboonwiwat, Kunlaya; Sarnow, Peter
  作者单位：Stanford University; Suranaree University of Technology; Chulalongkorn University; St Jude Children's Research Hospital; St Jude Children's Research Hospital; Natera, Inc.
  摘要：It is known that pre-mRNAs in eukaryotic cells can be processed to circular RNAs by a backsplicing mechanism. Circular RNAs have great stability and can sequester proteins or small RNAs to exert functions on cellular pathways. Because viruses often exploit host pathways, we explored whether the RNA genome of the cytoplasmic hepatitis C virus is processed to yield virus- derived circRNAs (vcircRNAs). Computational analyses of RNA-seq experiments predicted that the viral RNA genome is fragmented...
• Filament structure and subcellular organization of the bacterial intermediate filament-like protein crescentin AI翻译
  作者：Liu, Yue; van den Ent, Fusinita; Lowe, Jan
  作者单位：MRC Laboratory Molecular Biology; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); Zhejiang University; Zhejiang University
  摘要：The protein crescentin is required for the crescent shape of the freshwater bacterium Caulobacter crescentus (vibrioides). Crescentin forms a filamentous structure on the inner, concave side of the curved cells. It shares features with eukaryotic intermediate filament (IF) proteins, including the formation of static filaments based on long and parallel coiled coils, the protein's length, structural roles in cell and organelle shape determination and the presence of a coiled coil discontinuity ...
• Lysosome- related organelles contain an expansion compartment that mediates delivery of zinc transporters to promote homeostasis AI翻译
  作者：Mendoza, Adelita D.; Dietrich, Nicholas; Tan, Chieh- Hsiang; Herrera, Daniel; Kasiah, Jennysue; Payne, Zachary; Cubillas, Ciro; Schneider, Daniel L.; Kornfeld, Kerry
  作者单位：Washington University (WUSTL); National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); California Institute of Technology
  摘要：Zinc is an essential nutrient-it is stored during periods of excess to promote detoxification and released during periods of deficiency to sustain function. Lysosome- related organelles (LROs) are an evolutionarily conserved site of zinc storage, but mechanisms that control the directional zinc flow necessary for homeostasis are not well understood. In Caenorhabditis elegans intestinal cells, the CDF-2 transporter stores zinc in LROs during excess. Here, we identify ZIPT-2.3 as the transporter...