7期

最新文章

• Characterizing pathways of seafood access in small island developing states AI翻译
  作者：Seto, Katherine L.; Friedman, Whitney R.; Eurich, Jacob G.; Gephart, Jessica A.; Mason, Jessica Zamborain -; Sharp, Michael; Aram, Erietera; Tekaieti, Aritita; Tekiau, Aranteiti; Golden, Christopher D.
  作者单位：University of California System; University of California Santa Cruz; University of California System; University of California Santa Barbara; American University; Harvard University; Harvard T.H. Chan School of Public Health; University of Wollongong
  摘要：Ensuring healthy and sustainable food systems in increasing social, economic, and ecological change is a key global priority to protect human and environmental health. Seafood is an essential component of these food systems and a critical source of nutrients, especially in coastal communities. However, despite rapid transformations in aquatic food systems, and our urgent need to understand them, there is a dearth of data connecting harvested food production to actualized food consumption. Many...
• RNF20 contributes to epigenetic immunosuppression through CDK9-dependent LSD1 stabilization AI翻译
  作者：Dong, Bo; Wang, Xinzhao; Song, Xiang; Wang, Jianlin; Liu, Xia; Yu, Zhiyong; Zhou, Yongkun; Deng, Jiong; Wu, Yadi
  作者单位：University of Kentucky; University of Kentucky; Shandong University; Shandong First Medical University & Shandong Academy of Medical Sciences; University of Jinan; Shandong University of Traditional Chinese Medicine; Binzhou Medical University
  摘要：Cyclin- dependent kinase 9 (CDK9) plays a critical role in transcription initiation and is essential for maintaining gene silencing at heterochromatic loci. Inhibition of CDK9 increases sensitivity to immunotherapy, but the underlying mechanism remains unclear. We now report that RNF20 stabilizes LSD1 via K29- mediated ubiquitination, which is dependent on CDK9- mediated phosphorylation. This CDK9- and RNF20- dependent LSD1 stabilization is necessary for the demethylation of histone H3K4, then...
• Prebiotic access to enantioenriched amino acids via peptide- mediated transamination reactions AI翻译
  作者：Yu, Jinhan; Daru, Andrea; Deng, Min; Blackmond, Donna G.
  作者单位：University of Chicago; Scripps Research Institute
  摘要：The kinetic resolution of racemic amino acids mediated by dipeptides and pyridoxal provides a prebiotically plausible route to enantioenriched proteinogenic amino acids. The enzymatic transamination cycles that are key to modern biochemical formation of enantiopure amino acids may have evolved from this half of the reversible reaction couple. Kinetic resolution of racemic precursors emerges as a general route to enantioenrichment under prebiotic conditions. Significance While much progress has...
• G- quadruplex DNA structure is a positive regulator of MYC transcription AI翻译
  作者：Garcia, Isabel Esain -; Kirchner, Angie; Melidis, Larry; Tavares, Rafael de Cesaris Araujo; Dhir, Somdutta; Simeone, Angela; Yu, Zutao; Madden, Sarah K.; Hermann, Regina; Tannahill, David; Balasubramanian, Shankar
  作者单位：Cancer Research UK; CRUK Cambridge Institute; University of Cambridge; University of Cambridge; University of Cambridge
  摘要：DNA structure can regulate genome function. Four- stranded DNA G- quadruplex (G4) structures have been implicated in transcriptional regulation; however, previous studies have not directly addressed the role of an individual G4 within its endogenous cellular context. Using CRISPR to genetically abrogate endogenous G4 structure folding, we directly interrogate the G4 found within the upstream regulatory region of the critical human MYConcogene. G4 loss leads to suppression of MYC transcription ...
• Quantifying a light- induced energetic change in bacteriorhodopsin by force spectroscopy AI翻译
  作者：Jacobson, David R.; Perkins, Thomas T.
  作者单位：Clemson University; National Institute of Standards & Technology (NIST) - USA; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder
  摘要：Ligand- induced conformational changes are critical to the function of many membrane proteins and arise from numerous intramolecular interactions. In the photocycle of the model membrane protein bacteriorhodopsin (bR), absorption of a photon by retinal triggers a conformational cascade that results in pumping a proton across the cell membrane. While decades of spectroscopy and structural studies have probed this photocycle in intricate detail, changes in intramolecular energetics that underlie...
• Ultrahigh frequencies of peripherally matured LGI1-and CASPR2reactive B cells characterize the cerebrospinal fluid in autoimmune encephalitis AI翻译
  作者：Theorell, Jakob; Harrison, Ruby; Williams, Robyn; Raybould, Matthew I. J.; Zhao, Meng; Fox, Hannah; Fower, Andrew; Miller, Georgina; Wu, Zoe; Browne, Eleanor; Mgbachi, Victor; Sun, Bo; Mopuri, Rohini; Li, Ying; Waters, Patrick; Deane, Charlotte M.; Handel, Adam; Makuch, Mateusz; Irani, Sarosh R.
  作者单位：University of Oxford; Karolinska Institutet; Karolinska Institutet; Karolinska University Hospital; University of Oxford; University of Oxford; Mayo Clinic; Mayo Clinic; Mayo Clinic
  摘要：Intrathecal synthesis of central nervous system (CNS)- reactive autoantibodies is observed across patients with autoimmune encephalitis (AE), who show multiple residual neurobehavioral deficits and relapses despite immunotherapies. We leveraged two common forms of AE, mediated by leucine-rich glioma inactivated - 1 (LGI1) and contactin- associated protein - like 2 (CASPR2) antibodies, as human models to comprehensively reconstruct and profile cerebrospinal fluid (CSF) B cell receptor (BCR) cha...
• High life satisfaction reported among small- scale societies with low incomes AI翻译
  作者：Galbraith, Eric D.; Barrington-leigh, Christopher; Minarro, Sara; Fernandez, Santiago Alvarez-; Attoh, Emmanuel M. N. A. N.; Benyeia, Petra; Calvet-mira, Laura; Carmona, Rosario; Chakauya, Rumbidzayi; Chen, Zhuo; Chengula, Fasco; Fernandez-Llamazares, Alvaro; Garcia-del-amo, David; Glauser, Marcos; Huanca, Tomas; Izquierdo, Andrea E.; Junqueira, Andre B.; Lanker, Marisa; Li, Xiaoyue; Mariel, Juliette; Miara, Mohamed D.; Porcher, Vincent; Porcuna-Ferrer, Anna; Schlingmann, Anna; Seidler, Reinmar; Shrestha, Uttam Babu; Singh, Priyatma; Torrents-Tico, Miquel; Ulambayar, Tungalag; Wu, Rihan; Reyes-Garcia, Victoria
  作者单位：ICREA; McGill University; McGill University; McGill University; Wageningen University & Research; CGIAR; International Water Management Institute (IWMI); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Economia, Geografia y Demografia (IEGD); Autonomous University of Barcelona; Pontificia Universidad Catolica de Chile; University of South Africa; University of Helsinki; University of Dar es Salaam; University of Helsinki; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); National University of Cordoba; University of Wisconsin System; University of Wisconsin Madison; CIRAD; Universite Ibn Khaldoun Tiaret; Universite Ibn Khaldoun Tiaret; University of Massachusetts System; University of Massachusetts Boston; University of Helsinki; Peking University
  摘要：Global polls have shown that people in high- income countries generally report being more satisfied with their lives than people in low- income countries. The persistence of this correlation, and its similarity to correlations between income and life satisfaction within countries, could lead to the impression that high levels of life satisfaction can only be achieved in wealthy societies. However, global polls have typically overlooked small- scale, nonindustrialized societies, which can provi...
• DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8 AI翻译
  作者：Swarnkar, Gaurav; Semenkovich, Nicholas P.; Arra, Manoj; Mims, Dorothy K.; Naqvi, Syeda Kanwal; Peterson, Timothy; Mbalaviele, Gabriel; Wu, Chia- Lung; Abu-Amer, Yousef; Nathan, Carl F.
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); University of Rochester; Washington University (WUSTL)
  摘要：Epigenetic regulation plays a crucial role in the pathogenesis of autoimmune diseases such as inflammatory arthritis. DNA hypomethylating agents, such as decitabine (DAC), have been shown to dampen inflammation and restore immune homeostasis. In the present study, we demonstrate that DAC elicits potent anti- inflammatory effects and attenuates disease symptoms in several animal models of arthritis. Transcriptomic and epigenomic profiling show that DAC-mediated hypomethylation regulates a wide ...
• Cell cycle plasticity underlies fractional resistance to palbociclib in ER+/HER2-breast tumor cells AI翻译
  作者：Zikry, Tarek M.; Wolff, Samuel C.; Ranek, Jolene S.; Davis, Harris M.; Naugle, Ander; Luthra, Namit; Whitman, Austin A.; Kedziora, Katarzyna M.; Stallaert, Wayne; Kosorok, Michael R.; Spanheimer, Philip M.; Purvis, Jeremy E.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of North Carolina; University of North Carolina Chapel Hill
  摘要：The CDK4/6 inhibitor palbociclib blocks cell cycle progression in Estrogen receptor- positive, human epidermal growth factor 2 receptor-negative (ER+/HER2-) breast tumor cells. Despite the drug's success in improving patient outcomes, a small percentage of tumor cells continues to divide in the presence of palbociclib-a phenomenon we refer to as fractional resistance. It is critical to understand the cellular mechanisms underlying fractional resistance because the precise percentage of resista...
• Mechanistic links between physiology and spectral reflectance enable previsual detection of oak wilt and drought stress AI翻译
  作者：Sapes, Gerard; Schroeder, Lucy; Scott, Allison; Clark, Isaiah; Juzwik, Jennifer; Montgomery, Rebecca A.; Guzman, J. Antonio Q.; Bares, Jeannine Cavender-
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; State University System of Florida; University of Florida; University of Minnesota System; University of Minnesota Twin Cities; United States Department of Agriculture (USDA); United States Forest Service; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Tree mortality due to global change-including range expansion of invasive pests and pathogens-is a paramount threat to forest ecosystems. Oak forests are among the most prevalent and valuable ecosystems both ecologically and economically in the United States. There is increasing interest in monitoring oak decline and death due to both drought and the oak wilt pathogen (Bretziella fagacearum). We combined anatomical and ecophysiological measurements with spectroscopy at leaf, canopy, and airbor...