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最新文章

• A cholesterol- binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells AI翻译
  作者：Xu, Shimeng; Smothers, Jared C.; Rye, Daphne; Endapally, Shreya; Chen, Hong; Li, Shili; Liang, Guosheng; Kinnebrew, Maia; Rohatgi, Rajat; Posner, Bruce A.; Radhakrishnan, Arun
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Stanford University; Stanford University
  摘要：Lipid synthesis is regulated by the actions of Scap, a polytopic membrane protein that binds cholesterol in membranes of the endoplasmic reticulum (ER). When ER cholesterol levels are low, Scap activates SREBPs, transcription factors that upregulate genes for synthesis of cholesterol, fatty acids, and triglycerides. When ER cholesterol levels rise, the sterol binds to Scap, triggering conformational changes that prevent activation of SREBPs and halting synthesis of lipids. To achieve a molecul...
• Geological evidence of extensive N- fixation by volcanic lightning during very large explosive eruptions AI翻译
  作者：Aroskay, Adeline; Martin, Erwan; Bekki, Slimane; Le Pennec, Jean- Luc; Savarino, Joel; Temel, Abidin; Manrique, Nelida; Aguilar, Rigoberto; Rivera, Marco; Guillou, Herve; Balcone-Boissard, Helene; Phelip, Oceane; Szopa, Sophie
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Sorbonne Universite; Universite Paris Saclay; Ifremer; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Universite de Bretagne Occidentale; Institut Universitaire Europeen de la Mer (IUEM); Institut de Recherche pour le Developpement (IRD); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Hacettepe University; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU)
  摘要：Most of the nitrogen (N) accessible for life is trapped in dinitrogen (N2), the most stable atmospheric molecule. In order to be metabolized by living organisms, N2 has to be converted into biologically assimilable forms, so - called fixed N. Nowadays, nearly all the N- fixation is achieved through biological and anthropogenic processes. However, in early prebiotic environments of the Earth, N- fixation must have occurred via natural abiotic processes. One of the most invoked processes is elec...
• Direct binding to sterols accelerates endoplasmic reticulum- associated degradation of HMG CoA reductase AI翻译
  作者：Faulkner, Rebecca A.; Yang, Yangyan; Tsien, Jet; Qin, Tian; DeBose-Boyd, Russell A.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
  摘要：The maintenance of cholesterol homeostasis is crucial for normal function at both the cellular and organismallevels. Two integral membrane proteins, 3- hydroxy-3- methylglutaryl coenzyme A reductase (HMGCR) and Scap, are key targets of a complex feedback regulatory system that operates to ensure cholesterol homeostasis. HMGCR catalyzes the rate- limiting step in the transformation of the 2- carbon precursor acetate to 27- carbon cholesterol. Scap mediates proteolytic activation of sterol regul...
• Homophily, selection, and choice in segregation models AI翻译
  作者：Xu, Bing; Clark, William A. V.; Pak, Maxwell
  作者单位：Southwestern University of Finance & Economics - China; University of California System; University of California Los Angeles
  摘要：Schelling's 1971 work on the dynamics of segregation showed that even a small degree of homophily, the desire to live among like neighbors, can lead to a starkly segregated population. One of the driving factors for this result is that the notion of homophily used is based on group identities that are exogenous and immutable. In contrast, we consider a homophily that arises from the desire to be with neighbors who are behaviorally similar, not necessarily those who have the same group identity...
• Brain stimulation poised to move from last resort to frontline treatment AI翻译
  作者：Yam, Philip
• CURTAIN-A unique web- based tool for exploration and sharing of MS- based proteomics data AI翻译
  作者：Phung, Toan K.; Berndsen, Kerryn; Shastry, Rosamund; Phan, Tran L. C. H. B.; Muqit, Miratul M. K.; Alessi, Dario R.; Nirujogi, Raja S.
  作者单位：University of Dundee
  摘要：To facilitate analysis and sharing of mass spectrometry (MS) - based proteomics data, we created online tools called CURTAIN (https://curtain.proteo.info) and CURTAIN-PTM (https://curtainptm.proteo.info) with an accompanying series of video tutorials (https://www.youtube.com/@CURTAIN- me6hl). These are designed to enable non - MS experts to interactively peruse volcano plots and deconvolute primary experimental data so that replicates can be visualized in bar charts or violin plots and exporte...
• A consensus structural motif for the capsular polysaccharide of Cryptococcus Neoformans by NMR/MD AI翻译
  作者：Prestegard, James H.
  作者单位：University System of Georgia; University of Georgia
• Assessing the distribution of employment vulnerability to the energy transition using employment carbon footprints AI翻译
  作者：Graham, Kailin; Knittel, Christopher R.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); National Bureau of Economic Research
  摘要：As the world moves away from fossil fuels, there is growing recognition of the need for a just transition of those working in carbon -intensive industries and for policy to support this transition. While recent policies such as the U.S. Inflation Reduction Act (IRA) have begun to incorporate support for energy -intensive regions, little work has thoroughly investigated which communities are most vulnerable to economic disruption in the energy transition and therefore require policy support. Th...
• A radical polymer membrane for simultaneous degradation of organic pollutants and water filtration AI翻译
  作者：Li, Feng; Mi, Yixin; Chen, Ronn Zhi Ning; Liu, Wei; Wu, Ji; Hou, Deyin; Yang, Min; Zhang, Sui
  作者单位：National University of Singapore; Chinese Academy of Sciences; National University of Singapore; Southeast University - China; Purple Mountain Laboratories
  摘要：Integrating reactive radicals into membranes that resemble biological membranes has always been a pursuit for simultaneous organics degradation and water filtration. In this research, we discovered that a radical polymer (RP) that can directly trigger the oxidative degradation of sulfamethozaxole (SMX). Mechanistic studies by experiment and density functional theory simulations revealed that peroxyl radicals are the reactive species, and the radicals could be regenerated in the presence of O-2...
• Precision treatment of viral pneumonia through macrophage- targeted lipid nanoparticle delivery AI翻译
  作者：Zhao, Gan; Xue, Lulu; Geisler, Hannah C.; Xu, Junchao; Li, Xinyuan; Mitchell, Michael J.; Vaughan, Andrew E.
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
  摘要：Macrophages are integral components of the innate immune system, playing a dual role in host defense during infection and pathophysiological states. Macrophages contribute to immune responses and aid in combatting various infections, yet their production of abundant proinflammatory cytokines can lead to uncontrolled inflammation and worsened tissue damage. Therefore, reducing macrophage- derived proinflammatory cytokine release represents a promising approach for treating various acute and chr...